DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-gamma and chl1b

DIOPT Version :9

Sequence 1:	NP_651649.1	Gene:	DIP-gamma / 43417	FlyBaseID:	FBgn0039617	Length:	413	Species:	Drosophila melanogaster
Sequence 2:	XP_017212175.2	Gene:	chl1b / 100318566	ZFINID:	ZDB-GENE-091105-1	Length:	1294	Species:	Danio rerio

Alignment Length:	418	Identity:	83/418 - (19%)
Similarity:	142/418 - (33%)	Gaps:	114/418 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QNQH----HESSSQLDPDPEFIGFINNVTYPAGREAILACSVRNLGKNKVGWLRASDQTVLALQG 85
            :|.|    |.....::..|||.....:.....|.:.::.|.|:...:..|||         .:.|
Zfish   334 KNPHGEVVHHFHVTVEEPPEFEIEPQSQLVTIGADVLIKCVVKGNPQPTVGW---------RVNG 389

  Fly    86 R----VVTHNARISVMHQDMHTWKLKISKLRESDRGCYMCQINT--SPMKKQVGCIDVQVPPDII 144
            |    |.|.|.:|      :....:.|......:...|.|:...  ..:......:.:.:.|.|:
Zfish   390 RPLNEVPTSNRKI------LKDGTISIHNANPENSAVYQCEATNKHGTILANANIMIMNIQPLIL 448

  Fly   145 NEESSADLAVQEGEDATLTCKATGNPQPRVTWRRED------GEMILIRKPGSRELMKVESYNGS 203
            .|.:...:|| ||:...:.||...:|...:||.:.|      ||...:.:.||.|:..|
Zfish   449 TENNLQYMAV-EGKSVVMHCKVFSSPASSITWSKADSANAVEGERFTVHQNGSLEIHNV------ 506

  Fly   204 SLRLLRLERRQMGAYLCIASNDVPPAVSKRVSLSVQFAPMVRAPSQLLGTP------LGSDVQLE 262
                   .:..||.|.|.|.|     ...:|:::....  |:.|::::..|      .|:.:|..
Zfish   507 -------MKEDMGEYSCFAQN-----TEGKVAIAATLE--VKDPTRIVDPPRDLRVLAGTTIQFS 557

  Fly   263 CQVEASPSPVS----YWLKGARTSNGFASVSTASLESGSPGPEMLLDGPKYGITERRDGYRGVML 323
            ||.|..||...    .|.|.....||           ...|..:|.||                :
Zfish   558 CQPEFDPSFGDDFEVLWEKDGIALNG-----------SEDGRYILEDG----------------V 595

  Fly   324 LVVRSFSPSDVGTYHCVSTNSLGRAEGTLRLYEIKL-----------HPGASAS-----NDDH-- 370
            |.:.:.|..|.|.|.||:...:.:.....:|..:.:           |.|.|..     .|||
Zfish   596 LEIINVSFGDQGFYACVARTPVDQDVAVAQLSVVDVPDPPEDVILSEHNGRSVKLQWTPGDDHNS 660

  Fly   371 --LNYIGGLEEAARNAGRSNRTTWQPLL 396
              ..::...||:....|     :|:.::
Zfish   661 SITEFVLEFEESQHEPG-----SWREMM 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-gamma	NP_651649.1	IG_like	47..139	CDD:214653	15/97 (15%)
		Ig	47..129	CDD:299845	15/87 (17%)
		Ig	140..238	CDD:299845	26/103 (25%)
		IG_like	247..355	CDD:214653	24/117 (21%)
		Ig	256..351	CDD:299845	22/98 (22%)
chl1b	XP_017212175.2	Ig	61..135	CDD:325142
		Ig	138..231	CDD:325142
		Ig	279..348	CDD:325142	3/13 (23%)
		Ig	366..438	CDD:325142	15/86 (17%)
		IG	454..533	CDD:214652	23/99 (23%)
		I-set	538..628	CDD:333254	24/116 (21%)
		FN3	632..722	CDD:238020	10/57 (18%)
		FN3	734..815	CDD:238020
		FN3	832..931	CDD:238020
		fn3	942..1022	CDD:306538
		FN3	1070..1142	CDD:214495
		Bravo_FIGEY	1196..1279	CDD:316405
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12231
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100