DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11828 and P4HA1

DIOPT Version :9

Sequence 1:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_000908.2	Gene:	P4HA1 / 5033	HGNCID:	8546	Length:	534	Species:	Homo sapiens

Alignment Length:	529	Identity:	148/529 - (27%)
Similarity:	239/529 - (45%)	Gaps:	101/529 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRALGPADPTSYVANPLISFPLMRRTY 65
            |..|:..|.:|:..::.|....:.|:..::.:.|:.....:....||..:|.:|:.:|.||:|..
Human    28 MTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLTSTATKDPEGFVGHPVNAFKLMKRLN 92

  Fly    66 TDVPKLLELAREEFKPGPFQKFIDYDLSSI--------SDVELETAVTGMLRFQGVYGMDESEMA 122
            |:..:|..|..::...|    ||    |::        :|.:...|...:||.|..|.:|...::
Human    93 TEWSELENLVLKDMSDG----FI----SNLTIQRQYFPNDEDQVGAAKALLRLQDTYNLDTDTIS 149

  Fly   123 NGKLHGKQYNSRMSAADCLAVATHLENVDKGKLACK---------WFKVAIDQYEE----KLDPV 174
            .|.|.|.::.|.::|.||.         :.||:|..         |.:.|:.|.:|    .:|.|
Human   150 KGNLPGVKHKSFLTAEDCF---------ELGKVAYTEADYYHTELWMEQALRQLDEGEISTIDKV 205

  Fly   175 NRLLQTGRSQIYEK--LGLTLLAMHDL----PASQ------------AAFRDSIGWASKEDNTDL 221
            : :|......:|::  |...||....|    |..|            .|....:..::.:|.:|.
Human   206 S-VLDYLSYAVYQQGDLDKALLLTKKLLELDPEHQRANGNLKYFEYIMAKEKDVNKSASDDQSDQ 269

  Fly   222 AKHLKDKLAHMFVHVDN----------CRGKNLLPS---KSYLRCRYLRDG--SPFLRMAPVKLE 271
            ....|.|    .|.||.          |||:.:..:   :..|.||| .||  :|...:||.|.|
Human   270 KTTPKKK----GVAVDYLPERQKYEMLCRGEGIKMTPRRQKKLFCRY-HDGNRNPKFILAPAKQE 329

  Fly   272 QLNIEPFVGLFHDAISPAEQKDLLHLTDSRLE----HRKKDS--SSVEAKVDTNA------SDHV 324
            ....:|.:..|||.||.||.:.:..|...||.    |..:..  ::.:.:|..:|      :..|
Human   330 DEWDKPRIIRFHDIISDAEIEIVKDLAKPRLSRATVHDPETGKLTTAQYRVSKSAWLSGYENPVV 394

  Fly   325 RRIHQRIEDITGFDLEESEPLTVSNYGIGGQDFIHLDC---EQPKEFIGYYPKEY----RSASAM 382
            .||:.||:|:||.|:..:|.|.|:|||:|||...|.|.   ::|..|     ||.    |.|:.:
Human   395 SRINMRIQDLTGLDVSTAEELQVANYGVGGQYEPHFDFARKDEPDAF-----KELGTGNRIATWL 454

  Fly   383 FYLSDVQMGGYASFPDLGFGFKPRRGSALVWHNTDNSGNCDTRSLQATCPVLLGNQWVAKKWISG 447
            ||:|||..||...||::|....|::|:|:.|:|...||..|..:..|.||||:||:||:.||:..
Human   455 FYMSDVSAGGATVFPEVGASVWPKKGTAVFWYNLFASGEGDYSTRHAACPVLVGNKWVSNKWLHE 519

  Fly   448 SGQWRRKSC 456
            .||..|:.|
Human   520 RGQEFRRPC 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	30/132 (23%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	63/176 (36%)
P4HA1	NP_000908.2	P4Ha_N	25..112	CDD:400573	21/91 (23%)
		TPR	205..238		8/33 (24%)
		P4Hc	345..518	CDD:214780	64/177 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920