DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11828 and CG15864

DIOPT Version :9

Sequence 1:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_652183.2	Gene:	CG15864 / 50001	FlyBaseID:	FBgn0040528	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	140/501 - (27%)
Similarity:	228/501 - (45%)	Gaps:	102/501 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRALGPADPTSYVANPLISFPLMRRTY 65
            :..||::||||:..::.|...|:.|.|.|.....:.........:|..||:.|||.||.|:.|.:
  Fly    39 LMKLLEVEDELVDNLKGYVKTLKMKFNLMERSLIDMSRENMEMKSDYESYLGNPLNSFRLIHRLH 103

  Fly    66 TDVPKLLELAREEFKPGPFQKFIDYDLSSISDVE--------------LETAVTGMLRFQGVYGM 116
            |...|.            :|..|..:.:::..:|              |:.|..|:......|.:
  Fly   104 TSWRKW------------YQYAIKVENNALGHIENARLMRKMLPTSSDLQQACRGIHDLMSFYDL 156

  Fly   117 DESEMANGKLHG-KQYNSRMSAADCLAVATHLENVDKGKLACKWFKVAIDQYEEKLDPVNRLLQT 180
            ...|:|.|.|.| .|..:.::|.||||:........:..||..|:.:::.::|.|.|
  Fly   157 KPEELAAGNLAGYSQPGTGLTAYDCLALGEFSVQKREDDLAEAWYNLSLIRFENKFD-------- 213

  Fly   181 GRSQIYEKLGLTLLAMHDLPASQAAFRDSIGWASKEDNTDLAKHLKDK-----LAHMFVHV---- 236
             :.::::..||.|                   |..:..||...|.::|     .::..:|.
  Fly   214 -KYRVHKAWGLLL-------------------AKNKQLTDAFYHFENKPEGIIASNEVIHFKEEL 258

  Fly   237 ---DNCRGKNLLPSKSYLRCRYLRDGSPFLRMAPVKLEQLNIEPFVGLFHDAISPAEQKDLLH-- 296
               .||......||:  |.|||....:||.|:||:|:|:|.::|::.:|||.|...|...:|:
  Fly   259 STKQNCAVVVQKPSR--LHCRYNTTTTPFTRIAPLKMEELGLDPYMVVFHDVIYDTEIDGMLNSS 321

  Fly   297 -----LTDS--RLEHR-KKDSSSVEAKVDTNASDHVRRIHQRIEDITGFDLEESEPLTVSNYGIG 353
                 ||||  :.|.| .|||..|:||.          :::|:.|:|||.:|.|:|.::.|||:|
  Fly   322 NFGLSLTDSGQKSEVRTSKDSYIVDAKT----------LNERVTDMTGFSMEMSDPFSLINYGLG 376

  Fly   354 GQDFIHLDCEQ------PKEFIGYYPKEYRSASAMFYLSDVQMGGYASFPDLGFGFKPRRGSALV 412
            |...:|.|..:      ||:       ..|.|:.:|||.:|..||...||.:.....|::|||:.
  Fly   377 GHYMLHYDFHEYTNTTRPKQ-------GDRIATVLFYLGEVDSGGATIFPMINITVTPKKGSAVF 434

  Fly   413 WHNTDNSGNCDTRSLQATCPVLLGNQWVAKKWISGSGQWRRKSCRK 458
            |:|..|||..:.:||.:.|||:.|:::|..|||:...|.....|.|
  Fly   435 WYNLHNSGAMNLKSLHSACPVISGSKYVLTKWINELPQMFVTPCMK 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	33/138 (24%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	58/173 (34%)
CG15864	NP_652183.2	P4Ha_N	35..166	CDD:285528	33/138 (24%)
		metallo-dependent_hydrolases	<237..>306	CDD:294200	20/70 (29%)
		P4Hc	313..467	CDD:214780	58/170 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461841
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900