DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11828 and p4ha2

DIOPT Version :9

Sequence 1:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	XP_012814344.2	Gene:	p4ha2 / 493342	XenbaseID:	XB-GENE-957618	Length:	537	Species:	Xenopus tropicalis

Alignment Length:	520	Identity:	142/520 - (27%)
Similarity:	233/520 - (44%)	Gaps:	82/520 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRALGPADPTSYVANPLISFPLMRRTY 65
            |..|:..|.:|:..:::|..|.:.:::.::.:..|.....:...|||..|:.:|:.::.|::|..
Frog    30 MTDLIFRERDLLQSLKEYIREEEERLSKIKRWASEVDELSSRSTADPEGYLGHPVNAYKLVKRFN 94

  Fly    66 TDVPKLLELAREEFKPGPFQKFIDYDLSSISDVELET-AVTGMLRFQGVYGMDESEMANGKLHGK 129
            ||...|..|..::...|....| .:........|.|| |...::|.|..|.:|...:|.|||.|.
Frog    95 TDWSSLENLVLQDSAKGFIANF-TFQREYFPTEEDETGAARALMRIQDTYKLDPDVIAKGKLPGT 158

  Fly   130 QYNSRMSAADCLAVATHLENVDKGKLA---------CKWFKVAIDQYEE-------KLDPVNRL- 177
            .|.|.:||.|...:         ||:|         ..|.:.|:.|.:|       |:|.::.|
Frog   159 NYISSLSADDSFGM---------GKIAYHDGDYYHTVLWMQQALKQMDEGEDAVVNKVDVLDYLS 214

  Fly   178 ---LQTGRSQIYEKLGLT--LLAM---HDLPASQAAFRDSIGWASKED-------NTDLAKHLK- 226
               .|.|  .:...|.||  |||:   ||...:...:.:.:....|.:       ||:.|....
Frog   215 YTVFQLG--DVPRALELTKRLLALDPNHDRAVNNLKYFEKMQEKQKAELKQNESTNTESATRQPG 277

  Fly   227 ------DKLAHMFVHVDNCRGKNLLPS---KSYLRCRYLRDG--SPFLRMAPVKLEQLNIEPFVG 280
                  |.|....|:...|||:.:..:   :..|.||| .:|  ||:|.::|||:|.....|.:.
Frog   278 VYSRPLDYLPERDVYEALCRGEGVKMNPRRQRRLFCRY-HNGNRSPYLILSPVKVEDEWDSPRIV 341

  Fly   281 LFHDAISPAEQKDLLHLTDSRLEHRK-KDSS-----------SVEAKVDTNASDHVRRIHQRIED 333
            .:.:|:|..|...:..|...:|.... :|..           |..|.::.|....:.|::.|::.
Frog   342 RYLNALSDEEIAKIKELAKPKLARATVRDPKTGVLSVANYRVSKSAWLEENDDPVIARVNLRMQA 406

  Fly   334 ITGFDLEESEPLTVSNYGIGGQDFIHLDCEQPKEFIGYYPKEY-------RSASAMFYLSDVQMG 391
            |||..::.:|.|.|:|||:|||...|.|..:..|     |..:       |.|:.:.|:|||:.|
Frog   407 ITGLTVDTAELLQVANYGMGGQYEPHFDFSRKDE-----PDVFKRLGTGNRVATFLNYMSDVEAG 466

  Fly   392 GYASFPDLGFGFKPRRGSALVWHNTDNSGNCDTRSLQATCPVLLGNQWVAKKWISGSGQWRRKSC 456
            |...|||.|....|::|:|:.|:|...||..|.|:..|.||||:|::||:.||....||...:.|
Frog   467 GATVFPDFGAAIWPKKGTAVFWYNLFRSGEGDYRTRHAACPVLVGSKWVSNKWFHERGQEFLRPC 531

Fly 457 456
Frog 532 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	30/125 (24%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	56/176 (32%)
p4ha2	XP_012814344.2	P4Ha_N	27..113	CDD:400573	19/82 (23%)
		TPR repeat	166..201	CDD:276809	9/43 (21%)
		TPR repeat	206..236	CDD:276809	10/31 (32%)
		P4Hc	348..521	CDD:214780	57/177 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010