DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11828 and CG15539

DIOPT Version :9

Sequence 1:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001036776.1	Gene:	CG15539 / 43627	FlyBaseID:	FBgn0039782	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	146/494 - (29%)
Similarity:	238/494 - (48%)	Gaps:	63/494 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRALGPADPTSYVANPLISFPLMRRTY 65
            |:.|:..|..|:..::::|..||.:|:|:..:.|.....|....|:      :|:..|.:.||.:
  Fly    37 MSKLIDYEHYLLNILQKFANALQKRVDTLEYYLEMTDYDREKNLAE------DPIKHFRITRRLH 95

  Fly    66 TDVPKLLELAREEFKP-GPFQK---FIDYDLSSISDVELETAVTGMLRFQGVYGMDESEMANGKL 126
            :|....:....|:  | |...|   .|..::.::.||  |.|:.|:...|..|.:..:|||.|.|
  Fly    96 SDYVNWVWFMEEQ--PWGTLVKDIIAIAPEMPTLKDV--EEAIRGLRLIQWTYSLPTAEMAKGVL 156

  Fly   127 HGKQYNSRMSAADCLAVATHLENVDKGKLACKWFKVAIDQYE--EKLDPVNRLLQTGRSQIYE-- 187
            ....:|:.:....|:.:|.|:.|......|.:|..|.:..||  |:::.:...|.......||
  Fly   157 QDIHHNTSLDGMQCITIARHMVNYKDFIRAKEWLMVGLKMYEADEEIEYIYSQLGMPLVDFYELF 221

  Fly   188 -----KLGLTLLAMHDLPASQAAFRDSIGWASK----------EDNTDLAK---HLKDKLAHMFV 234
                 :||...|||.:|   |.|.::   |..|          :.|..:.|   ..|:|...::
  Fly   222 VEIQDELGSRYLAMSEL---QLAIKN---WPEKVSLQRALSRLKMNIRIGKEPAEKKNKSKRVY- 279

  Fly   235 HVDNCRGKNLLPSKSYLRCRYLRDGSPFLRMAPVKLEQLNIEPFVGLFHDAISPAEQKDLLHLTD 299
              ..|......|: :.|.|.|....|.|||:||:|:|.|:::|::.||||.:|..:...:.:||.
  Fly   280 --KKCCSSECRPT-AKLYCLYKTTSSYFLRLAPLKMELLSLDPYMVLFHDVVSDKDIVSIRNLTK 341

  Fly   300 SRLEHR---KKDSSSVEAK---------VDTNASDHVRRIHQRIEDITGFDLEESEPLTVSNYGI 352
            .:|...   .||.:..|..         |:.||.  ::|:.|..:|:|.||:.:::|..|.||||
  Fly   342 GKLARTVTVSKDGNYTEDPDRTTKGTWLVENNAL--IQRLSQLTQDMTNFDIHDADPFQVLNYGI 404

  Fly   353 GGQDFIHLDCEQPKEFIGYYPKEYRSASAMFYLSDVQMGGYASFPDLGFGFKPRRGSALVWHNTD 417
            ||...||.|..:..|...:   ..|.|:|:||||||..||...||.||....|::||||:|:|.|
  Fly   405 GGFYGIHFDFLEDAELDNF---SDRIATAVFYLSDVPQGGATIFPKLGLSVFPKKGSALLWYNLD 466

  Fly   418 NSGNCDTRSLQATCPVLLGNQWVAKKWISGSGQWRRKSC 456
            :.|:.|.|:..:.||.::|::||..|||:...|..|:.|
  Fly   467 HKGDGDNRTAHSACPTVVGSRWVMTKWINEREQIFRRPC 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	33/128 (26%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	60/169 (36%)
CG15539	NP_001036776.1	P4Ha_N	33..156	CDD:285528	33/128 (26%)
CG15539	NP_001036776.1	P4Hc	329..494	CDD:214780	60/169 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461844
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900