DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11828 and PH4alphaSG2

DIOPT Version :9

Sequence 1:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_651801.1	Gene:	PH4alphaSG2 / 43623	FlyBaseID:	FBgn0039779	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	141/521 - (27%)
Similarity:	228/521 - (43%)	Gaps:	104/521 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLLQIEDELIGYMRQYAMELQHKVNTMRTFQE------EWMTRRALGPADPTSYVANPLISFP 59
            |..|.|:|:||:...|.|....|.:::..|.:.|      ||.|.:    .....|:.:||.:|.
  Fly    32 MQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIKREHEWATSQ----LKLDDYLGHPLHAFR 92

  Fly    60 LMRRTYTD------VPKLLELAREEFKPGPFQKFIDYDLSSISDVELETAVTGMLRFQGVYGMDE 118
            |::|...|      .|.|...|||||:  .|.:.:..||......||:.|:.|:.|.|.||.:..
  Fly    93 LIKRLVRDWDSLIFEPILANNAREEFR--AFVEVLSRDLGYPDQSELQGAIKGLARLQKVYNLAT 155

  Fly   119 SEMANGKLHGKQYNSRMSAADCLAVATHLENVDKGKLACKWFKVAI-------------DQY--- 167
            |::|:|.:.|..|.|.:...:|..:...|.::.:.:.:.:|.:||.             |.|
  Fly   156 SDLADGIIGGLNYGSDLRWRECYEIGVQLFDLGEYQRSLEWLQVAFILLRNSPREEKDADHYLSD 220

  Fly   168 -EEKLDPVN----------RLLQTGRSQIYEKLGLTLLAMHDLPASQAAFRDSIGWASKEDNTDL 221
             .|.....|          |||    |||.|.     ...|....:|......:.
  Fly   221 IREYASMANFELGNPKKAARLL----SQILES-----QPTHSAQQTQKYLESRVP---------- 266

  Fly   222 AKHLKDKLAHMFVHVDN-CRGKNLLPSKS--YLRCRYLRDGS--PFLRMAPVKLEQLNIEPFVGL 281
            .|::::.....|.:... |:|:.|...:|  .||| || ||.  .:..:||:::|.::::|.:.:
  Fly   267 GKNVQETKPSWFSNYTRLCQGRRLPEERSGDPLRC-YL-DGKRHAYFTLAPLQVEPVHLDPDINV 329

  Fly   282 FHDAISPAEQKDLLHLTDSRLEHRKKDSSSVEAKVDTNASDHVR--RIHQR-------------- 330
            :|..:|   .|.:|    |..|...|:.....|...:.....||  |:.|:
  Fly   330 YHGMLS---SKQIL----SIFEEADKEEMVRSAVAGSGGEGTVRDLRVSQQTWLDYKSPVMNSVG 387

  Fly   331 --IEDITGFDLEESEPLTVSNYGIGGQDFIHLD---CEQPKEFIGYYPKEYRSASAMFYLSDVQM 390
              |:.::|||:..:|.:.|:|||:|||...|.|   ...||.|.|     .|.:::|||||||:.
  Fly   388 RIIQFVSGFDMAGAEHMQVANYGVGGQYEPHPDYFEVNLPKNFEG-----DRISTSMFYLSDVEQ 447

  Fly   391 GGYASFPDLGFGFKPRRGSALVWHNTDNSGNCDTRSLQATCPVLLGNQWVAKKWISGSGQWRRKS 455
            |||..|..|.....|.:|:.::|||...|.:.|.|:|.|.|||::|::.:...|:....|..|:.
  Fly   448 GGYTVFTKLNVFLPPVKGALVMWHNLHRSLHVDARTLHAGCPVIVGSKRIGNIWMHSGYQEFRRP 512

  Fly   456 C 456
            |
  Fly   513 C 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	42/136 (31%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	56/178 (31%)
PH4alphaSG2	NP_651801.1	P4Ha_N	28..163	CDD:285528	42/136 (31%)
PH4alphaSG2	NP_651801.1	P4Hc	335..503	CDD:214780	57/179 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461840
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900