DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11828 and p4ha2

DIOPT Version :9

Sequence 1:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	XP_005173949.1	Gene:	p4ha2 / 373132	ZFINID:	ZDB-GENE-030827-1	Length:	542	Species:	Danio rerio

Alignment Length:	541	Identity:	149/541 - (27%)
Similarity:	239/541 - (44%)	Gaps:	118/541 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRALGPADPTSYVANPLISFPLMRRTY 65
            |.:|:..|.||:..:::|....:.|:.|:|::..:.........:||..::|:|:.::.||:|..
Zfish    29 MTNLIFTERELVQSLKEYIQAEEQKLETVRSWANKLDKLTRTSTSDPEGFLAHPVNAYKLMKRLN 93

  Fly    66 TDVPKLLELAREEFKPGPFQKFIDYDLSSIS-------DVELET-AVTGMLRFQGVYGMDESEMA 122
            |:..:|..|..::    |...||    |::|       |.|.|. |...:||.|..|.:|....:
Zfish    94 TEWSELESLVLQD----PSDGFI----SNMSVHRQYFPDEEDEKGAAKALLRLQDTYKLDAESFS 150

  Fly   123 NGKLHGK------QYNSRMSAADCLAVATHLENVDKGKLACK---------WFKVAIDQYEEKLD 172
            .|||.|:      :||:.::..||.         |.||:|..         |.:.::.|.:.
Zfish   151 KGKLPGQRQHSGVRYNALLTVDDCF---------DMGKMAYNDNDYYHSVLWMQQSLRQMDS--- 203

  Fly   173 PVNRLLQTGRSQIYEKLGLTLLAMHDL--------------PASQAA--------------FRDS 209
              ....:|.::.:.:.|..::..|.||              |:.|.|              .:||
Zfish   204 --GEEAKTPKADVLDYLSYSVYQMGDLPRAIELTRRLLAIDPSHQRAGGNLRYFERLLSKELQDS 266

  Fly   210 IGWASKED------NTDLAKHLKDKLAHMFVHVDNCRG---KNLLPSKSYLRCRYLRDG--SPFL 263
             |....|.      ..|..:..||.|.....:...|||   |.....:|.|.||| |||  :|.|
Zfish   267 -GQTQPEPADERPIQLDTYQRPKDYLPEREAYEALCRGEGVKMTTKRQSRLFCRY-RDGNRNPRL 329

  Fly   264 RMAPVKLEQLNIEPFVGLFHDAISPAEQKDLLHLTDSRL----------------EHRKKDSSSV 312
            .:.|:|.|.....|.:..|.:|:|..|.:.:..:...:|                .:|...|:.:
Zfish   330 LLKPMKEEDEWDSPHIVRFLEALSDEEIQKIKEIATPKLARATVRDPKTGVLTVAHYRVSKSAWL 394

  Fly   313 EAKVDTNASDHVRRIHQRIEDITGFDLEESEPLTVSNYGIGGQDFIHLDCEQPKEFIGYYPKEYR 377
            |.:.|    ..:.|::||||||||..::.:|.|.|:|||:|||...|.|..:..|     |..::
Zfish   395 EGEDD----PVIARVNQRIEDITGLTVDTAELLQVANYGVGGQYEPHFDFSRKDE-----PDAFK 450

  Fly   378 S-------ASAMFYLSDVQMGGYASFPDLGFGFKPRRGSALVWHNTDNSGNCDTRSLQATCPVLL 435
            |       |:.:.|:|||:.||...|||.|....||:|:|:.|:|...||..|.|:..|.||||:
Zfish   451 SLGTGNRVATYLNYMSDVEAGGATVFPDFGASVWPRKGTAVFWYNLFRSGEGDYRTRHAACPVLV 515

  Fly   436 GNQWVAKKWISGSGQWRRKSC 456
            |::||:.|||...||..|:.|
Zfish   516 GSKWVSNKWIHERGQEFRRPC 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	34/132 (26%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	60/180 (33%)
p4ha2	XP_005173949.1	P4Ha_N	25..154	CDD:285528	34/132 (26%)
p4ha2	XP_005173949.1	P4Hc	353..526	CDD:214780	61/181 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920