DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11828 and P4ha2

DIOPT Version :9

Sequence 1:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_001101745.1	Gene:	P4ha2 / 360526	RGDID:	1309673	Length:	535	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	133/524 - (25%)
Similarity:	234/524 - (44%)	Gaps:	92/524 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRALGPADPTSYVANPLISFPLMRRTY 65
            |..|:..|.:|:..:::|.:..:.|::.::::..:.....:...|||..|:|:|:.::.|::|..
  Rat    30 MTDLIYAEKDLVQSLKEYILAEEAKLSKIKSWASKMEALTSKSAADPEGYLAHPVNAYKLVKRLN 94

  Fly    66 TDVPKLLELAREEFKPGPFQKFIDYDLSSIS--------DVELETAVTGMLRFQGVYGMDESEMA 122
            ||.|.|.:|..::...|    |:    :::|        |.:...|...::|.|..|.:|...::
  Rat    95 TDWPALGDLVLQDAAAG----FV----ANLSVQRQFFPTDEDESGAARALMRLQDTYKLDPDMIS 151

  Fly   123 NGKLHGKQYNSRMSAADCLAVATH-----------------LENVDKGK-------LACKWFKVA 163
            .|:|.|.:|.:.:|..||..:...                 |:.:|.|:       |...:...|
  Rat   152 RGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATVTKSLVLDYLSYA 216

  Fly   164 IDQ---YEEKLDPVNRLLQT--------GRSQIYEKLGLTLLAMHDLPASQAAFRDSIGWASKED 217
            :.|   ....::...|||..        |..:.:|:|      :.:......:.:...|.||:|
  Rat   217 VFQLGDLHRAVELTRRLLSLDPSHERAGGNLRYFERL------LEEERGKSLSNQTDAGLASQE- 274

  Fly   218 NTDLAKHLKDKLAHMFVHVDNCRGKNLLPS---KSYLRCRYLRDGS--PFLRMAPVKLEQLNIEP 277
              :|.:...|.|....|:...|||:.:..:   :..|.||| ..|:  |.|.:||.|.|.....|
  Rat   275 --NLYERPVDYLPERDVYESLCRGEGIKMTPRRQKRLFCRY-HHGNRVPQLLIAPFKEEDEWDSP 336

  Fly   278 FVGLFHDAISPAEQKDLLHLTDSRL----------------EHRKKDSSSVEAKVDTNASDHVRR 326
            .:..::|.:|..|.:.:..:...:|                .:|...||.:|...|    ..|.|
  Rat   337 HIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDD----PVVAR 397

  Fly   327 IHQRIEDITGFDLEESEPLTVSNYGIGGQDFIHLDCEQPKEFIGYYPKEY----RSASAMFYLSD 387
            :::|::.|||..::.:|.|.|:|||:|||...|.|..:..|...:  |..    |.|:.:.|:||
  Rat   398 VNRRMQHITGLTVKTAELLQVANYGMGGQYEPHFDFSRSDERDAF--KRLGTGNRVATFLNYMSD 460

  Fly   388 VQMGGYASFPDLGFGFKPRRGSALVWHNTDNSGNCDTRSLQATCPVLLGNQWVAKKWISGSGQWR 452
            |:.||...|||||....|::|:|:.|:|...||..|.|:..|.||||:|.:||:.||....||..
  Rat   461 VEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEF 525

  Fly   453 RKSC 456
            .:.|
  Rat   526 LRPC 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	29/132 (22%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	58/177 (33%)
P4ha2	NP_001101745.1	P4Ha_N	27..104	CDD:400573	18/73 (25%)
P4ha2	NP_001101745.1	P4Hc	346..519	CDD:214780	59/178 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920