DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11828 and PH4alphaSG1

DIOPT Version :9

Sequence 1:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_733376.1	Gene:	PH4alphaSG1 / 326112	FlyBaseID:	FBgn0051014	Length:	540	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	134/524 - (25%)
Similarity:	231/524 - (44%)	Gaps:	99/524 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRALGPADPTSYVANPLISFPLMRR----- 63
            ||.:|..::....:|....|.:...::.|.:: :..:.....|...|..||:.:|..::|
  Fly    30 LLDVEAFIVEKFDEYLERAQQEQENLKRFLDQ-IDEQQNDRGDLEEYFGNPINAFITIKRLVHDW 93

  Fly    64 ---------------TY----TDVPKLLELAREEFKPGPFQKFIDYDLSSISDVELETAVTGMLR 109
                           ||    :|     .|.:..|| ||.|:            :|..|...:||
  Fly    94 KFNVFDPVFDSSNFETYKNNLSD-----SLEKINFK-GPTQE------------DLHGATRALLR 140

  Fly   110 FQGVYGMDESEMANGKLHGKQYN---SRMSAADCLAVATHLENVDKGKLACKWFKVAIDQYEEKL 171
            .|.:|.::...:|:|.||..:.|   :.:||:||..:..:|..:.:.....:|...|..:...|
  Fly   141 LQNMYQLNTDHLASGVLHPGEKNALGTSLSASDCFELGKNLCEIKEYSYGSEWLLEARKRLHGK- 204

  Fly   172 DPVNRL--------LQTGRSQIYEKLGLTLLA-------MHDLPASQAAFRDSI---GWASKEDN 218
             |:..:        :....|..:..||...||       :...|..:.|.::.|   |..::|.:
  Fly   205 -PLGFISPNVSDVEILEHLSSAFNGLGNLKLAYKLNNEILDKKPDHEEALKNKILYEGQLARERS 268

  Fly   219 TDLAKHL-------KDKLAHMFVHVDNCRGK-NLLP-SKSYLRCRYLRDGSPFLRMAPVKLEQLN 274
            ....|.:       |::.....::...|||: :..| .:..|||.....|.|:.|::|.|:||||
  Fly   269 FAPRKQVELPQIAEKEQKESYKLYTQVCRGELHQSPREQRNLRCWLYHQGVPYYRLSPFKIEQLN 333

  Fly   275 IEPFVGLFHDAISPAEQKDLLHLTDSRLEHRK-----------KDSSSVEAKVDTN------ASD 322
            ::|:|...|:.:..:|       .|:.:||.|           ::|::.|.::..|      |:.
  Fly   334 VDPYVAYVHEVLWDSE-------IDTIMEHGKGNMERSKVGQSENSTTSEVRISRNTWLWYDANP 391

  Fly   323 HVRRIHQRIEDITGFDLEESEPLTVSNYGIGGQDFIHLDCEQPKEFIGYYPKEYRSASAMFYLSD 387
            .:.:|.||:||:||...|.:|||.:.|||||||...|.|..:......:..|..|..:|:|||:|
  Fly   392 WLSKIKQRLEDVTGLSTESAEPLQLVNYGIGGQYEPHFDFVEDDGQSVFSWKGNRLLTALFYLND 456

  Fly   388 VQMGGYASFPDLGFGFKPRRGSALVWHNTDNSGNCDTRSLQATCPVLLGNQWVAKKWISGSGQWR 452
            |.:||..:||.|.....|.:||.|:|:|..:|.:.|.|:..|.||||.|::|:..:|.....|..
  Fly   457 VALGGATAFPFLRLAVPPVKGSLLIWYNLHSSTHKDFRTKHAGCPVLQGSKWICNEWFHVGAQEF 521

  Fly   453 RKSC 456
            |:.|
  Fly   522 RRPC 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	29/145 (20%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	58/174 (33%)
PH4alphaSG1	NP_733376.1	P4Ha_N	23..157	CDD:285528	29/145 (20%)
PH4alphaSG1	NP_733376.1	P4Hc	347..515	CDD:214780	59/174 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461960
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	79	1.000	Inparanoid score	I2378
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	1	1.000	-	-		mtm1209
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
	9	8.900