DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11828 and phy-2

DIOPT Version :9

Sequence 1:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_502317.1	Gene:	phy-2 / 178170	WormBaseID:	WBGene00004025	Length:	539	Species:	Caenorhabditis elegans

Alignment Length:	500	Identity:	137/500 - (27%)
Similarity:	224/500 - (44%)	Gaps:	56/500 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRALGPADPTSYVANPLISFPLMRRTYTDV 68
            :|..|.::...:.||....:.:::.:|.:..|::.|.|...:....:|.||:.::.|::|..|:.
Worm    28 MLGAEKDVTTIIDQYIEAERARLDDLRRYAHEYVHRNAHAESVGPEFVTNPINAYLLIKRLTTEW 92

  Fly    69 PKLLELAREEFKPGPFQKFIDYDLSSISDV------ELETAVTGMLRFQGVYGMDESEMANGKLH 127
            .|:..:.... |...|.|.|. |....|:|      :|..|.|.:||.|..|.:|..:::||.:.
Worm    93 KKVENIMLNN-KASTFLKNIT-DNRVRSEVKFPGEEDLSGAATALLRLQDTYSLDTLDLSNGIIG 155

  Fly   128 GKQYNSRMSAADCLAVATHLENVDKGKLAC-KWFKVAIDQYEEKLDP-----------VNRLLQT 180
            |::.::::|..|...|.....| .|....| .|.:||:.:.|.:..|           ...|.|.
Worm   156 GEKVSNKLSGHDTFEVGRSAYN-QKDYYHCLMWMQVALVKIENENPPTIEEWEILEYLAYSLYQQ 219

  Fly   181 GRSQIYEKLGLTLLAMHDLPASQAAFRDSIGW-----ASKEDNTDLA----KHLK-DKLAHMFVH 235
            |  .:...|.||.......|....| :.::.|     ..|:...||.    |.:: |.:.....:
Worm   220 G--NVRRALSLTKRLAKIAPNHPRA-KGNVKWYEDMLQGKDMVGDLPPIVNKRVEYDGIVERDAY 281

  Fly   236 VDNCRGKNLLPS-----KSYLRCRYLRDGSPFLRMAPVKLEQLNIEPFVGLFHDAISPAEQKDLL 295
            ...|||:  :|.     |:.||| ||:...|||::||:|:|.|..:|...||.:.|..:|.:.:.
Worm   282 EALCRGE--IPPVEPKWKNKLRC-YLKRDKPFLKLAPIKVEILRFDPLAVLFKNVIHDSEIEVIK 343

  Fly   296 HLTDSRLEHRKKDSS------------SVEAKVDTNASDHVRRIHQRIEDITGFDLEESEPLTVS 348
            .|...:|:.....:|            |..|.:..:....:.|:::||||.|..:...||.|.|:
Worm   344 ELASPKLKRATVQNSKTGELEHATYRISKSAWLKGDLDPVIDRVNRRIEDFTNLNQATSEELQVA 408

  Fly   349 NYGIGGQDFIHLDCEQPKEFIGYYPKE--YRSASAMFYLSDVQMGGYASFPDLGFGFKPRRGSAL 411
            |||:||....|.|..:.:|...:....  .|.|:.:||:|..:.||...|..||....|.:..||
Worm   409 NYGLGGHYDPHFDFARKEEKNAFKTLNTGNRIATVLFYMSQPERGGATVFNHLGTAVFPSKNDAL 473

  Fly   412 VWHNTDNSGNCDTRSLQATCPVLLGNQWVAKKWISGSGQWRRKSC 456
            .|:|....|..|.|:..|.||||||.:||:.|||...||...:.|
Worm   474 FWYNLRRDGEGDLRTRHAACPVLLGVKWVSNKWIHEKGQEFTRPC 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	32/127 (25%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	52/171 (30%)
phy-2	NP_502317.1	P4Ha_N	21..154	CDD:285528	32/127 (25%)
		TPR_16	169..240	CDD:290168	16/73 (22%)
		P4Hc	335..508	CDD:214780	53/172 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920