DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11828 and p4ha1

DIOPT Version :9

Sequence 1:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	XP_031761963.1	Gene:	p4ha1 / 100490484	XenbaseID:	XB-GENE-987760	Length:	526	Species:	Xenopus tropicalis

Alignment Length:	520	Identity:	146/520 - (28%)
Similarity:	231/520 - (44%)	Gaps:	90/520 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRALGPADPTSYVANPLISFPLMRRTY 65
            |..||..|.:|:..::.|....:.|:..::.:.::..........||..|:.:|:.:|.||:|..
Frog    27 MIDLLNTEKDLVTSLKDYIKAEEQKLAQIKKWADKLDHLTDTATKDPEGYLGHPVNAFKLMKRLN 91

  Fly    66 TDVPKLLELAREEFKPGPFQKFIDYDLSSI--------SDVELETAVTGMLRFQGVYGMDESEMA 122
            |:..||..|..::...|    ||    |::        :|.:...|...:||.|..|.:|...::
Frog    92 TEWVKLENLILKDISDG----FI----SNLTIQRQYFPNDEDQTGAAKALLRLQDTYNLDTDTIS 148

  Fly   123 NGKLHGKQYNSRMSAADCLAVATHLENVDKGKLACK---------WFKVAIDQY----EEKLDPV 174
            .|.|.|.::.:.::|.||.         |.||.|..         |.:.|:.|.    |..||.|
Frog   149 KGNLPGVKHKTSLTAEDCF---------DLGKTAYTDADYYHTELWMEQALSQLDAGEESSLDKV 204

  Fly   175 NRLLQTGRSQIYEK------LGLTLLAMHDLPASQAAFRDSIGWASKEDNTDLAK-----HLKDK 228
             .:|......:|::      |.||..::...|..|....:.....|||.|...:.     .|:.:
Frog   205 -MVLDYLSYAVYQQGDLDKALTLTKRSLELDPEHQRGNGNLRHIMSKESNKSSSSPSEGAELRTR 268

  Fly   229 LAHMFVHVDN------CRGKNL-LPSKSYLR--CRYLRDG--SPFLRMAPVKLEQLNIEPFVGLF 282
            ......|::.      |||:.: :.|:...|  |||. ||  .|.|.::|.|.|....:|.:..:
Frog   269 KGRPKDHLEKEKYEKLCRGEGVKMTSRRQKRLFCRYF-DGKKDPLLILSPTKQEDEWDKPRIVRY 332

  Fly   283 HDAISPAEQKDLLHLTDSRLEHRKKDSSSVEAKVDT-------------NASDHVRRIHQRIEDI 334
            ||.||..|...:..|...|| .|...|:.:...::|             .....|.|:::|||.:
Frog   333 HDIISDEEISKVKELAKPRL-RRATISNPITGVLETAQYRITKSAWLSGYEDPVVARLNRRIEGV 396

  Fly   335 TGFDLEESEPLTVSNYGIGGQDFIHLDCEQPKEFI-GYYPKEY-------RSASAMFYLSDVQMG 391
            ||.|:..:|.|.|:|||||||...|.|      |: .|.|..:       |.|:.:||:|||:.|
Frog   397 TGLDMSTAEELQVANYGIGGQYEPHFD------FLRKYEPDAFKKLGTGNRVATWLFYMSDVEAG 455

  Fly   392 GYASFPDLGFGFKPRRGSALVWHNTDNSGNCDTRSLQATCPVLLGNQWVAKKWISGSGQWRRKSC 456
            |...||::|....|::|:|:.|:|...||..|..:..|.||||:||:||:.|||...||..|:.|
Frog   456 GATVFPEVGAAVYPKKGTAVFWYNLLESGEGDYSTRHAACPVLVGNKWVSNKWIHERGQEFRRPC 520

Fly 457 456
Frog 521 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	31/132 (23%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	61/178 (34%)
p4ha1	XP_031761963.1	P4Ha_N	24..111	CDD:400573	22/91 (24%)
p4ha1	XP_031761963.1	P4Hc	337..510	CDD:214780	62/179 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110