DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11828 and p4ha1b

DIOPT Version :9

Sequence 1:	NP_651648.5	Gene:	CG11828 / 43416	FlyBaseID:	FBgn0039616	Length:	458	Species:	Drosophila melanogaster
Sequence 2:	NP_999856.1	Gene:	p4ha1b / 100003675	ZFINID:	ZDB-GENE-030131-4089	Length:	536	Species:	Danio rerio

Alignment Length:	531	Identity:	145/531 - (27%)
Similarity:	238/531 - (44%)	Gaps:	103/531 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASLLQIEDELIGYMRQYAMELQHKVNTMRTFQEEWMTRRALGPADPTSYVANPLISFPLMRRTY 65
            |..||..|.:|:..:::|..:.::::..::.:.::..:.......||..::.:|:.:|.||:|..
Zfish    28 MTDLLYAEKDLVTSLKEYIKQEENRLEQVKEWADKLDSLTITATQDPEGFLGHPVNAFKLMKRLN 92

  Fly    66 TDVPKLLELAREEFKPGPFQKFIDYDLSSI--------SDVELETAVTGMLRFQGVYGMDESEMA 122
            ::...|..|..::...|    ||    |::        :|.:...|...:||.|..|.:..:.::
Zfish    93 SEWSDLENLVLKDTTNG----FI----SNLTVQRQYFPTDEDQTGAAKALLRLQDTYQLSANAIS 149

  Fly   123 NGKLHGKQYNSRMSAADC-----------------LAVATHLENVDKGK-------LACKWFKVA 163
            :|.|.|..:.|||:..||                 |.:|..|..:|:|:       ....:...|
Zfish   150 SGDLPGVVHKSRMTVEDCYELGKIAYSDADYYHTELWMAQALSQLDEGEESPIDKVTVMDYLSYA 214

  Fly   164 IDQYEE------------KLDPVNRLLQTGRSQIYEKLGLTLLAMHDLPASQAAFRDSIGWASKE 216
            |.|..|            |||| |.....|..:.:|         ..|...:.|..:.    .:|
Zfish   215 IYQQGELDRALELTKRMLKLDP-NHHRANGNLKYFE---------FQLEKQRKAENEK----KEE 265

  Fly   217 DNTDL-------AKHLKDKLAHMFVHVDNCRGK--NLLPSK-SYLRCRYLRDG-SPFLRMAPVKL 270
            |...:       .|..||.|.....:...|||:  .|.|.: |.|.|||..:. :|.|.:||||.
Zfish   266 DQKRVLDKRDAQRKRSKDPLPERKKYERLCRGEGIKLTPRRQSRLFCRYSNNNRNPRLLLAPVKQ 330

  Fly   271 EQLNIEPFVGLFHDAISPAEQKDLLHLTDSRLEHRKKDSSSVEAKVDT-----------NASDH- 323
            |.....|.:..:|:.||.:|.:.:..:...|| .|...|:.:...::|           :..:|
Zfish   331 EDEWDRPRIVRYHEIISDSEIETVKEMAKPRL-RRATISNPITGVLETAPYRISKSAWLSGYEHS 394

  Fly   324 -VRRIHQRIEDITGFDLEESEPLTVSNYGIGGQDFIHLDC---EQPKEFIGYYPKEY----RSAS 380
             :.||:|||||:||.:::.:|.|.|:|||:|||...|.|.   ::|..|     ||.    |.|:
Zfish   395 TIERINQRIEDVTGLEMDTAEELQVANYGVGGQYEPHFDFGRKDEPDAF-----KELGTGNRIAT 454

  Fly   381 AMFYLSDVQMGGYASFPDLGFGFKPRRGSALVWHNTDNSGNCDTRSLQATCPVLLGNQWVAKKWI 445
            .:||:|||..||...|.|:|....|::|:|:.|:|...||..|..:..|.||||:||:||:.|||
Zfish   455 WLFYMSDVSAGGATVFTDVGAAVWPKKGTAVFWYNLFPSGEGDYSTRHAACPVLVGNKWVSNKWI 519

  Fly   446 SGSGQWRRKSC 456
            ...||..|:.|
Zfish   520 HERGQEFRRPC 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11828	NP_651648.5	P4Ha_N	1..126	CDD:285528	26/132 (20%)
CG11828	NP_651648.5	P4Hc	287..445	CDD:214780	62/177 (35%)
p4ha1b	NP_999856.1	P4Ha_N	24..153	CDD:285528	26/132 (20%)
		TPR repeat	164..199	CDD:276809	7/34 (21%)
		TPR_16	168..238	CDD:290168	13/70 (19%)
		TPR repeat	204..234	CDD:276809	4/29 (14%)
		P4Hc	347..520	CDD:214780	63/178 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D192165at33208
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10869
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X129
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920