DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and DYRK1B

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_004705.1	Gene:	DYRK1B / 9149	HGNCID:	3092	Length:	629	Species:	Homo sapiens

Alignment Length:	456	Identity:	126/456 - (27%)
Similarity:	197/456 - (43%)	Gaps:	96/456 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1644 QHQPHQQQQNEMSKSALGLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVK 1708
            |..|.|...|:..|..|...:         ||.:...|..:|:....||:|.:.:|:|:||:|||
Human    72 QQAPPQDSSNKKEKKVLNHGY---------DDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVK 127

  Fly  1709 VKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEM 1773
            ..|.:....:|:|||||.:.:...|::|:..||.:.|.|....:..|.:...|.:..|:|:|||:
Human   128 AYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFEL 192

  Fly  1774 LGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLT--HTDLKPENILFVDSDYTSHYN 1836
            |..:::|.||..::....|:..|.:|.|||.::.||....|:  |.||||||||..:.
Human   193 LSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNP------- 250

  Fly  1837 HKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFE 1901
                      |.:.::::||||:....:.....:.:|.||:|||:|...:....|:||:||||.|
Human   251 ----------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVE 305

  Fly  1902 LYLGITLFQTHDNREHLAMMERILGQIPYRM------ARNH---------TLYSKTKTKYFYHGK 1951
            ::.|..||...:..:.:..:..:||..|..|      ||.:         ||....:.:..|.|.
Human   306 MHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGP 370

  Fly  1952 --------LDWDEKSSAGRYVRD--HCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEA 2006
                    |........||...:  |          ...|:.....|:.:||||||::||:...|
Human   371 GTRRLQEVLGVQTGGPGGRRAGEPGH----------SPADYLRFQDLVLRMLEYEPAARISPLGA 425

  Fly  2007 LHHPFFDRLPPHHRVGEVSNKQPL----------------------------SSGSSSRERSHSL 2043
            |.|.||.|     ...|.:|..|.                            ||||||..|::..
Human   426 LQHGFFRR-----TADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRY 485

  Fly  2044 S 2044
            |
Human   486 S 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	104/359 (29%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	101/346 (29%)
DYRK1B	NP_004705.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	67..89		5/16 (31%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	69..86		4/13 (31%)
		PKc_DYRK1	97..436	CDD:271128	107/370 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	380..399		3/28 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	436..629		11/51 (22%)
		Interaction with RANBP9. /evidence=ECO:0000269\|PubMed:14500717	480..520		2/7 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810