DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and PRPF4B

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_003904.3	Gene:	PRPF4B / 8899	HGNCID:	17346	Length:	1007	Species:	Homo sapiens

Alignment Length:	996	Identity:	202/996 - (20%)
Similarity:	378/996 - (37%)	Gaps:	250/996 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1132 ESGPGDSASLERKSEKSNSTLSTSSFTVTNCCTTHLPQLSKFTSSFHIAPTTATTTAATATPTPT 1196
            |||..:...:..|:...|.:.:.||.|               .....:.....||...:.:.:..
Human   141 ESGSEEEGEIHEKARNGNRSSTRSSST---------------KGKLELVDNKITTKKRSKSRSKE 190

  Fly  1197 GAATTSDQQQQSGGTPAMVAANLEVPTSSSSSAATKRQKDVDNKLEKCLNDMLKLKTSSNNNSTS 1261
            .....||:::..||        :|:....::.:.:|.:|              |.|:.|..   |
Human   191 RTRHRSDKKKSKGG--------IEIVKEKTTRSKSKERK--------------KSKSPSKR---S 230

  Fly  1262 NSNNNAIMSHSLTGEHKDPKTALEGPTSSSSSSSSKYIGESQIPV--PVQLYDPQK-------PL 1317
            .|.:.|..|.|.|...:                |.:.||:::.|.  .|::.|..|       |:
Human   231 KSQDQARKSKSPTLRRR----------------SQEKIGKARSPTDDKVKIEDKSKSKDRKKSPI 279

  Fly  1318 LQQQQQQQRICYPIGKSNSTSQLPMGGYQRLLQHQQQQHHQQQQQQHQEQQQYPQHKRPFLNWNS 1382
            :.:.:.:.|     ||.   |:.|:.     |:.:.:....:.:::..::.:..:.|:|..:.:.
Human   280 INESRSRDR-----GKK---SRSPVD-----LRGKSKDRRSRSKERKSKRSETDKEKKPIKSPSK 331

  Fly  1383 FACSAMNGASDPFMQQQHMPAHQQQQHLPHKLQQSYSSSHVPKQAPKSGLAMFLQKNTNKENKFG 1447
            .|.|.         ::...|:.:     |.:..:..|.|..|:...:...:..|....:|::|
Human   332 DASSG---------KENRSPSRR-----PGRSPKRRSLSPKPRDKSRRSRSPLLNDRRSKQSK-- 380

  Fly  1448 QPMQQQPPGMM------------PQMYGYQAP-----------QQQSKIGYP------------- 1476
            .|.:...||..            |:.....:|           :::||...|
Human   381 SPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILSRRERSKDASPINRWSPTRRRSRS 445

  Fly  1477 ----RTGAPLTHS-----ASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMS 1532
                |:.:||..|     .|.|..:|....:...:.:::...:..::...:.:.:...| .|.:|
Human   446 PIRRRSRSPLRRSRSPRRRSRSPRRRDRGRRSRSRLRRRSRSRGGRRRRSRSKVKEDKF-KGSLS 509

  Fly  1533 RNYYNMPKQPERKPLQTFDPYAYPKPNQMQPVKYQQQ---QQHPHTQFQNASAGGGGGGAAGLQY 1594
            .......:......|:.||.....:...::..:.|:|   |::.:                 |..
Human   510 EGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKY-----------------LAE 557

  Fly  1595 DPNTNTQLFYASPASSSSNKQPQQPQ--QQQQQQQSQLQQSNSVIFNHSGQ-QHQPHQQQQNEMS 1656
            |.|.:.....:||.||:..:.|....  ::......:.::.|...|..|.: :|.....:||..|
Human   558 DSNMSVPSEPSSPQSSTRTRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGS 622

  Fly  1657 K----------------------------SALGLHFIETAKPVIQD---DADGHLIYHTGDILHH 1690
            .                            :.:|..|.|  .|.::|   ||:|:...:.|::|..
Human   623 SQKKLLAPDMFTESDDMFAAYFDSARLRAAGIGKDFKE--NPNLRDNWTDAEGYYRVNIGEVLDK 685

  Fly  1691 RYKIMATLGEGTFGRVVKVKDMER-DYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLC 1754
            ||.:....|:|.|..||:.:|..| :..:|:|||:|.|..::....|:..|:|:...||.....|
Human   686 RYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHC 750

  Fly  1755 VKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLD------QVRHMAYQLCYSVKFLHDNR 1813
            :::...|.:..|:|:|||.|.:::.:.|::     |..|      .||..:.||..::|.|....
Human   751 LRLFRHFYHKQHLCLVFEPLSMNLREVLKK-----YGKDVGLHIKAVRSYSQQLFLALKLLKRCN 810

  Fly  1814 LTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATF--DHEHHSTIVSTRHYR 1876
            :.|.|:||:|||..:|                  .|.::|.|||||:.  |::....:|| |.||
Human   811 ILHADIKPDNILVNES------------------KTILKLCDFGSASHVADNDITPYLVS-RFYR 856

  Fly  1877 APEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARNHTLYSK 1941
            |||:|:...:....|:||:||.|:|||.|..||....|...|.:...:.|::|.:|.|....
Human   857 APEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVF--- 918

  Fly  1942 TKTKYFYHG---------KLDWDEK---SSAGRYVRDHCKPLFLCQLSDSED----HCELFSLIK 1990
             |.::|...         |:...||   .|.....:|....|..||....:.    | :|..|:.
Human   919 -KDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVH-QLKDLLD 981

  Fly  1991 KMLEYEPSSRITLGEALHHPF 2011
            ::|..:|:.||::.:||.|.|
Human   982 QILMLDPAKRISINQALQHAF 1002

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	103/358 (29%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	100/345 (29%)
PRPF4B	NP_003904.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..99
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..533		73/477 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	559..583		6/23 (26%)
		STKc_PRP4	686..1003	CDD:271037	101/346 (29%)
		S_TKc	694..1003	CDD:214567	99/338 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810