DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and KNS1

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_013081.1	Gene:	KNS1 / 850641	SGDID:	S000003942	Length:	737	Species:	Saccharomyces cerevisiae

Alignment Length:	757	Identity:	201/757 - (26%)
Similarity:	320/757 - (42%)	Gaps:	207/757 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1377 FLNWNSFACS------AMNGASDPFMQQQHMPAHQQQQHLPHK-----------------LQQSY 1418
            |...|||...      .:|.|.:|...:|    ||.|..|.::                 ...::
Yeast    52 FARQNSFLTDNLRNSLDLNQADNPLRPRQ----HQHQLFLDNENAIELDEEPRIINTTINNSNNH 112

  Fly  1419 SSSHVPKQAPKSGLAMFLQKNTNKENKFGQPMQQQPPGMMPQMYGYQAPQQQSKIGYPRTGAPLT 1483
            :||.|.:.|...  .:|:::         ||:|...|.::|................|..|...|
Yeast   113 NSSRVDEDADDD--IIFIKE---------QPIQFSSPLILPSSSSINNNNNIVTSNNPGCGTAAT 166

  Fly  1484 HSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKPLQ 1548
            .::::.:..:        :.::|:.:...|....:..:|          .||:|:|.|
Yeast   167 SNSTYITTPK--------KFKKQRTISLPQLPLSKLSYQ----------SNYFNVPDQ------- 206

  Fly  1549 TFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSN 1613
                     .|.:.|...|.:.:..|..           |:.....:.|....|..|...|..||
Yeast   207 ---------TNAIVPRVTQTENELLHLT-----------GSCAKTLEGNKAVNLTIAHSTSPFSN 251

  Fly  1614 KQPQ---QPQQQQQQQ-QSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFIETAKPVIQD 1674
            ...|   .||...::| .|.|::..|                 |..|:||      .:.|...:.
Yeast   252 PPAQIASLPQSNLKKQIGSSLRKFTS-----------------NGSSESA------SSNKSNFKT 293

  Fly  1675 DADGHLIYHTGDILHH--RYKIMATLGEGTFGRVVKVKD--MERDYCMALKIIKNVEKYREAAKL 1735
            |.|||.:|...||...  |:.:...||:||||:|:|..|  .|.:| :|:|:|:.|::||||||.
Yeast   294 DKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNY-VAVKVIRAVDRYREAAKT 357

  Fly  1736 EINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAY 1800
            |:..|:.|...||.....|:.:.:.|||..|:|:|.::.|.|::||:..|....:|...::.:|.
Yeast   358 ELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIAR 422

  Fly  1801 QLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKI-----------NREVRR-----VKNT 1849
            ||..||.||||..:.||||||||||..|.   :|...|:           .||..:     :||.
Yeast   423 QLIRSVCFLHDLGIIHTDLKPENILICDE---THIAQKLPLKTVQSLSKRRREASKGKRKILKNP 484

  Fly  1850 DVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDN 1914
            ::::||||||.|.:|:|..::|||||||||::|.||||.|||:|||.|:|.||.:|.:|:..|:|
Yeast   485 EIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHEN 549

  Fly  1915 REHLAMMERILG-------------QIPYRMARNHTLYSKTKTKYFYHG--KLDWDEKSSAG--- 1961
            .||:|||:||.|             :..:::..:.:..:.|..|:|...  .|.|.||:..|
Yeast   550 LEHMAMMQRINGTPFPTDIIDKMFYKSKHKLGNSPSDLNSTVIKHFDRKTLSLQWPEKNKRGDTI 614

  Fly  1962 ------RYVRDHCKPL--FLCQL--------------------------------------SDSE 1980
                  :.|...|..|  ::.::                                      |.:.
Yeast   615 TTEKSMKRVLQSCDRLDIYISKVLKQDYGDSLSINWNLPPEKNWSLINSKLAWKRQTHSSSSSTT 679

  Fly  1981 DHCE----LF-----SLIKKMLEYEPSSRITLGEALHHPFFD 2013
            |..:    ||     .|::||.|::|:.|||..:||.|.:|:
Yeast   680 DELDKETFLFWYWFIDLLRKMFEFDPTKRITAKDALDHEWFN 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	141/425 (33%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	136/410 (33%)
KNS1	NP_013081.1	PKc_CLK	298..720	CDD:271036	141/425 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	251	1.000	Domainoid score	I340
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1597
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	1	1.000	-	-		oto99239
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	LDO	PTHR45646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R660
SonicParanoid	1	1.000	-	-		X440
TreeFam	1	0.960	-	-
	11	10.750