Protein Alignment Doa and KNS1

DIOPT Version :10

• Sequence 1: NP_001014681.2
• Gene: Doa / 43415
• FlyBaseID: FBgn0265998
• Length: 2045
• Species: Drosophila melanogaster
• Sequence 2: NP_013081.1
• Gene: KNS1 / 850641
• SGDID: S000003942
• Length: 737
• Species: Saccharomyces cerevisiae
• Alignment Length: 757
• Identity: 201/757 - (26%)
• Similarity: 320/757 - (42%)
• Gaps: 207/757 - (27%)

  Fly  1377 FLNWNSFACS------AMNGASDPFMQQQHMPAHQQQQHLPHK-----------------LQQSY 1418
            |...|||...      .:|.|.:|...:|    ||.|..|.::                 ...::
Yeast    52 FARQNSFLTDNLRNSLDLNQADNPLRPRQ----HQHQLFLDNENAIELDEEPRIINTTINNSNNH 112

  Fly  1419 SSSHVPKQAPKSGLAMFLQKNTNKENKFGQPMQQQPPGMMPQMYGYQAPQQQSKIGYPRTGAPLT 1483
            :||.|.:.|...  .:|:::         ||:|...|.::|................|..|...|
Yeast   113 NSSRVDEDADDD--IIFIKE---------QPIQFSSPLILPSSSSINNNNNIVTSNNPGCGTAAT 166

  Fly  1484 HSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKPLQ 1548
            .::::.:..:        :.::|:.:...|....:..:|          .||:|:|.|
Yeast   167 SNSTYITTPK--------KFKKQRTISLPQLPLSKLSYQ----------SNYFNVPDQ------- 206

  Fly  1549 TFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSN 1613
                     .|.:.|...|.:.:..|..           |:.....:.|....|..|...|..||
Yeast   207 ---------TNAIVPRVTQTENELLHLT-----------GSCAKTLEGNKAVNLTIAHSTSPFSN 251

  Fly  1614 KQPQ---QPQQQQQQQ-QSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFIETAKPVIQD 1674
            ...|   .||...::| .|.|::..|                 |..|:||      .:.|...:.
Yeast   252 PPAQIASLPQSNLKKQIGSSLRKFTS-----------------NGSSESA------SSNKSNFKT 293

  Fly  1675 DADGHLIYHTGDILHH--RYKIMATLGEGTFGRVVKVKD--MERDYCMALKIIKNVEKYREAAKL 1735
            |.|||.:|...||...  |:.:...||:||||:|:|..|  .|.:| :|:|:|:.|::||||||.
Yeast   294 DKDGHYVYQENDIFGSGGRFVVKDLLGQGTFGKVLKCIDNKYEPNY-VAVKVIRAVDRYREAAKT 357

  Fly  1736 EINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAY 1800
            |:..|:.|...||.....|:.:.:.|||..|:|:|.::.|.|::||:..|....:|...::.:|.
Yeast   358 ELRILQTILNNDPQGQFQCLLLRECFDYKNHICLVTDLYGRSIYDFMCSNGIARFPGSHIQAIAR 422

  Fly  1801 QLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKI-----------NREVRR-----VKNT 1849
            ||..||.||||..:.||||||||||..|.   :|...|:           .||..:     :||.
Yeast   423 QLIRSVCFLHDLGIIHTDLKPENILICDE---THIAQKLPLKTVQSLSKRRREASKGKRKILKNP 484

  Fly  1850 DVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDN 1914
            ::::||||||.|.:|:|..::|||||||||::|.||||.|||:|||.|:|.||.:|.:|:..|:|
Yeast   485 EIKIIDFGSAIFHYEYHPPVISTRHYRAPEIVLGLGWSFPCDIWSIACVLVELVIGESLYPIHEN 549

  Fly  1915 REHLAMMERILG-------------QIPYRMARNHTLYSKTKTKYFYHG--KLDWDEKSSAG--- 1961
            .||:|||:||.|             :..:::..:.:..:.|..|:|...  .|.|.||:..|
Yeast   550 LEHMAMMQRINGTPFPTDIIDKMFYKSKHKLGNSPSDLNSTVIKHFDRKTLSLQWPEKNKRGDTI 614

  Fly  1962 ------RYVRDHCKPL--FLCQL--------------------------------------SDSE 1980
                  :.|...|..|  ::.::                                      |.:.
Yeast   615 TTEKSMKRVLQSCDRLDIYISKVLKQDYGDSLSINWNLPPEKNWSLINSKLAWKRQTHSSSSSTT 679

  Fly  1981 DHCE----LF-----SLIKKMLEYEPSSRITLGEALHHPFFD 2013
            |..:    ||     .|::||.|::|:.|||..:||.|.:|:
Yeast   680 DELDKETFLFWYWFIDLLRKMFEFDPTKRITAKDALDHEWFN 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PHA03247	<205..634	CDD:223021
		PKc_CLK	1679..2012	CDD:271036	141/425 (33%)
KNS1	NP_013081.1	PKc_CLK	298..720	CDD:271036	141/425 (33%)