DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and DYRK3

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_003573.2	Gene:	DYRK3 / 8444	HGNCID:	3094	Length:	588	Species:	Homo sapiens

Alignment Length:	648	Identity:	161/648 - (24%)
Similarity:	263/648 - (40%)	Gaps:	181/648 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  1454 PPGMMPQMYGYQAPQQQSKIG---------YPRTGAPLTHSASFSSAQRP-------TALQFHQQ 1502
            |||.       ..|.||.::|         ...|..|...:...:.::.|       |..||...
Human    15 PPGA-------GLPPQQRRLGDGVYDTFMMIDETKCPPCSNVLCNPSEPPPPRRLNMTTEQFTGD 72

  Fly  1503 HQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKPLQTFDPYAYPKPNQMQPVKYQ 1567
            |.                 ||...|              .|.|..|.|..:...|.|.:|.....
Human    73 HT-----------------QHFLDG--------------GEMKVEQLFQEFGNRKSNTIQSDGIS 106

  Fly  1568 QQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSNKQPQ----QPQQQQQQQQS 1628
            ..::...|..|..|:             ...||      ..|:||:|.|:    .|:|..:|.:.
Human   107 DSEKCSPTVSQGKSS-------------DCLNT------VKSNSSSKAPKVVPLTPEQALKQYKH 152

  Fly  1629 QLQQSNSV-IFNHSGQQHQPHQQQQNEMSKSALGLHFI-ETAKP---VI-------QDDADGHLI 1681
            .|.....: |.|:      |.             ::|: ..||.   ||       .|||||..|
Human   153 HLTAYEKLEIINY------PE-------------IYFVGPNAKKRHGVIGGPNNGGYDDADGAYI 198

  Fly  1682 YHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQK 1746
            :...|.|.:||:::..:|:|:||:|.:|.|.:....:|||:::|.:::...|..||..||.:.::
Human   199 HVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHRQAAEEIRILEHLKKQ 263

  Fly  1747 DPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHD 1811
            |.......:.|::.|.:..|:|:.||:|.:.:::.:::|.::.:.:..||..|..:..|:..||.
Human   264 DKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVRKFAQSILQSLDALHK 328

  Fly  1812 NRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYR 1876
            |::.|.||||||||.      .|:.           .:..::|||||:.|:::...|.:.:|.||
Human   329 NKIIHCDLKPENILL------KHHG-----------RSSTKVIDFGSSCFEYQKLYTYIQSRFYR 376

  Fly  1877 APEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARNHTLYSK 1941
            |||:||...:|.|.|:||.||||.||..|..||...|..:.||.|..:||..|.::     |...
Human   377 APEIILGSRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMMELLGMPPPKL-----LEQS 436

  Fly  1942 TKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSED------------------------- 1981
            .:.|||.:.|       ...||          |.::...|
Human   437 KRAKYFINSK-------GIPRY----------CSVTTQADGRVVLVGGRSRRGKKRGPPGSKDWG 484

  Fly  1982 ----HCE--LF-SLIKKMLEYEPSSRITLGEALHHPFFDRLPPH--HRVGEVSNKQPLSSGSS 2035
                .|:  || ..:|:.|.::||:|:|..:||.||:..:..|.  ..:.:||.|:.::..|:
Human   485 TALKGCDDYLFIEFLKRCLHWDPSARLTPAQALRHPWISKSVPRPLTTIDKVSGKRVVNPASA 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	105/364 (29%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	101/351 (29%)
DYRK3	NP_003573.2	Disordered. /evidence=ECO:0000305\|PubMed:23415227	1..188		46/248 (19%)
		PKc_DYRK2_3	143..522	CDD:271126	122/436 (28%)
		S_TKc	209..522	CDD:214567	101/351 (29%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:29973724	468..481		0/12 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810