DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and Hipk3

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	XP_038961862.1	Gene:	Hipk3 / 83617	RGDID:	619884	Length:	1213	Species:	Rattus norvegicus

Alignment Length:	610	Identity:	149/610 - (24%)
Similarity:	261/610 - (42%)	Gaps:	135/610 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1483 THSASFSSAQR----PTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPE 1543
            |.|::|.|.::    |:...|.::...|.|:.                     .|::.|.....:
  Rat    15 TQSSAFCSVKKLKVEPSGCVFQERACPQIHVN---------------------GRHFGNPLPSTK 58

  Fly  1544 RKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPA 1608
            ....||..|::.|:.:..                 :..||      |.:..|....|::. |:.|
  Rat    59 GSAFQTKIPFSKPRGHSF-----------------SLQAG------AIVVKDTAGATKVI-AAQA 99

  Fly  1609 SSSSNKQPQQPQQQQQ------QQQSQLQQSNSVIFNHSGQQH-------QPHQQQQNEMSKSAL 1660
            ..:..:.|:....:.:      .|:..|::.:..:.||||...       .|...|.|..:...:
  Rat   100 QQAGVEAPRAVVWRNRLHFLGGPQRCGLKRKSEELDNHSGAMQIVDELSILPAMLQTNMGNPVTV 164

  Fly  1661 GLHFIETAKPVIQDDADGHLIYHTGDIL---HHRYKIMATLGEGTFGRVVKVKDMERDYCMALKI 1722
            ......:.:.....:.|..|:.|  ::|   .:.|:::..||.||||:|||......:..:|:||
  Rat   165 VTATTGSKQNCTSGEGDYQLVQH--EVLCSVKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKI 227

  Fly  1723 IKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNY 1787
            :||...|....::|::.|.:::.::.. ::..|:..:.|.:..|.|:|||||..:::|||::|.:
  Rat   228 LKNHPSYARQGQIEVSILARLSTENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291

  Fly  1788 EPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVR 1852
            .|.||..:|.:..|:..::|.|....|.|.|||||||:.||.          .|:..|||
  Rat   292 SPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDP----------VRQPYRVK----- 341

  Fly  1853 LIDFGSATFDHEHH------STIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQ- 1910
            :||||||:     |      ||.:.:|:|||||:||.|.:.:..|:||:||::.||:||..|:.
  Rat   342 VIDFGSAS-----HVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPG 401

  Fly  1911 --THDNREHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLDW------DEKSSAGRYVRDH 1967
              .:|...:::..:.:.|:....:....|.:...:|...:.|   |      :.::..|...::.
  Rat   402 ALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSG---WRLKTLEEHEAETGMKSKEA 463

  Fly  1968 CKPLFLC-----------------QLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDRL 2015
            .|.:|..                 .|::..|..|..||:||||..:...|||..|.|:|||
  Rat   464 RKYIFNSLDDIVHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPIETLNHPF---- 524

  Fly  2016 PPHHRVGEVSNKQPLSSGSSSRERS 2040
                    ||.|..|....||..:|
  Rat   525 --------VSMKHLLDFPHSSHVKS 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	109/367 (30%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	106/351 (30%)
Hipk3	XP_038961862.1	STKc_HIPK3	196..525	CDD:271131	107/364 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810