DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and hipk1

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	XP_012819927.1	Gene:	hipk1 / 734033	XenbaseID:	XB-GENE-987412	Length:	1218	Species:	Xenopus tropicalis

Alignment Length:	576	Identity:	147/576 - (25%)
Similarity:	244/576 - (42%)	Gaps:	122/576 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1485 SASFSSAQR----PTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERK 1545
            |::|.||::    |:......|....::....:..|..|.|..||..|.     .:::|
Frog    15 SSAFCSAKKLKVEPSGWDVTGQGSSNKYYTHTKNLPVAQGHASSSHQVA-----GFSLP------ 68

  Fly  1546 PLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASS 1610
                    || :||.:.|                         ||..::...|......:.|.:|
Frog    69 --------AY-EPNLLIP-------------------------AAAAEHIVVTAADSTDSGPTTS 99

  Fly  1611 SSNKQ-----PQQPQQQQQQQQSQLQQSNSVIFNHSGQ---QHQPHQQQQNEMSKSALGLHFIET 1667
            ..|.|     ...|.....|:....::|..|..|.|.|   :..|...|...:..:|.....:.|
Frog   100 FQNSQILTHRSNVPLLDPYQKCGLKRKSEEVDSNGSVQIIDERPPLMLQNRTVVGAAATTTTVTT 164

  Fly  1668 AKPVIQDDADGHLIYHTGDIL---HHRYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKY 1729
            .......:.|..|:.|  :||   .:.|:::..||.||||:|.|.........:|:||:||...|
Frog   165 KSSSSNGEGDYQLVQH--EILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSY 227

  Fly  1730 REAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQ 1794
            ....::|::.|.:::.::.. ::..|:..:.|.:..|.|:|||||..:::|||::|.:.|.||..
Frog   228 ARQGQIEVSILSRLSSENAD-EYNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKY 291

  Fly  1795 VRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSA 1859
            :|.:..|:..::..|....|.|.|||||||:.||.          .|:..|||     :||||||
Frog   292 IRPILQQVATALMKLKSLGLIHADLKPENIMLVDP----------VRQPYRVK-----VIDFGSA 341

  Fly  1860 TFDHEHH------STIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHL 1918
            :     |      ||.:.:|:|||||:||.|.:.:..|:||:||::.||:||..|:......:.:
Frog   342 S-----HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQI 401

  Fly  1919 AMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLD-----W------DEKSSAGRYVRDHCKPLF 1972
            ..:.:..|     :...:.|.:.|||..|::...|     |      :.:...|...::..|.:|
Frog   402 RYISQTQG-----LPAEYLLSAGTKTSRFFNRDPDLGYPLWRLKAPDEHEMETGIKSKEARKYIF 461

  Fly  1973 LC-----------------QLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPF 2011
            .|                 .|::..|..|...|:||||..:...|||..:.|:|||
Frog   462 NCLDDMAQVNMSTDLEGTDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHPF 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	110/370 (30%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	106/354 (30%)
hipk1	XP_012819927.1	STKc_HIPK1	174..528	CDD:271130	111/372 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910