DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and Dyrk2

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	XP_006514109.3	Gene:	Dyrk2 / 69181	MGIID:	1330301	Length:	665	Species:	Mus musculus

Alignment Length:	697	Identity:	174/697 - (24%)
Similarity:	283/697 - (40%)	Gaps:	175/697 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1408 QHLPHKLQQSYSSSHVPKQAPKSGLAMFLQKNTNKENKFGQPMQQQPPGMMPQMYGYQAPQQQSK 1472
            |.||..:..|..|:.||   |:|  ..|..:..:...:    ..|..||:     |..||:....
Mouse    59 QPLPSSMLGSPGSAAVP---PRS--LTFRGRGGDTAVR----QLQASPGI-----GAGAPRSGVG 109

  Fly  1473 IGYPRTGA--PLTHSASFSSAQRPTALQFH----QQHQQQQHLQQQQQHPQQQQHQHSSFGVGMM 1531
            .|.|...|  ||..|.:.::|        |    .:|....||         ..:.|....|..:
Mouse   110 TGPPSPIALPPLRASNATTTA--------HTIGGSKHTMNDHL---------HLNSHGQIQVQQL 157

  Fly  1532 SRNYYNMPKQPERKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDP 1596
            ..:..|     :|..|.|       :||.:..|                       |..||...|
Mouse   158 FEDNSN-----KRTVLTT-------QPNGLTTV-----------------------GKTGLPGVP 187

  Fly  1597 NTNTQLFYASPASSSSNK----------QPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQ 1651
            ....:..:....||:|.|          .|..|:|..:|...:|     ..|.|......|....
Mouse   188 ERQLESIHRRQGSSTSLKSMEGMGKVKASPMTPEQAMKQYMQKL-----TAFEHHEIFSYPEIYF 247

  Fly  1652 QNEMSKSALGLHFIETAKPVI--QDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMER 1714
            ....:|...|:    |..|..  .||..|..:....|.:.:||:::..:|:|:||:|||..|.:.
Mouse   248 LGPNAKKRQGM----TGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKV 308

  Fly  1715 DYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVF 1779
            ...:|||:::|.:::...|..||..||.:.::|.......:.|::.|.:..|:|:.||:|.::::
Mouse   309 HQHVALKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLY 373

  Fly  1780 DFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVR 1844
            :.:::|.::.:.|..||..|:.:...:..||.||:.|.||||||||                 ::
Mouse   374 ELIKKNKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENIL-----------------LK 421

  Fly  1845 RVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLF 1909
            :...:.:::|||||:.::|:...|.:.:|.||||||||...:..|.|:||:||||.||..|..|.
Mouse   422 QQGRSSIKVIDFGSSCYEHQRVYTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLL 486

  Fly  1910 QTHDNREHLAMMERILGQIPYRM------ARNHTLYSKTKTKY-----------------FYHGK 1951
            ...|..:.||.|..:||....::      |:|. :.||...:|                 ...||
Mouse   487 PGEDEGDQLACMIELLGMPSQKLLDASKRAKNF-VSSKGYPRYCTVTTLSDGSVVLNGGRSRRGK 550

  Fly  1952 L-------DWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHH 2009
            |       :|      |..::....||||             ..:|:.||::|:.|:|.|:||.|
Mouse   551 LRGPPESREW------GNALKGCDDPLFL-------------DFLKQCLEWDPAVRMTPGQALRH 596

  Fly  2010 PFFDRLPPHHRVGEVS---------------NKQPLSSGSSSRERSH 2041
            |:..|..|....||.:               :|.|..|.|:|:.|::
Mouse   597 PWLRRRLPKPPTGEKTAVKRVTESTGAITSISKLPPPSSSASKLRTN 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	105/362 (29%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	103/349 (30%)
Dyrk2	XP_006514109.3	PKc_DYRK2_3	220..599	CDD:271126	119/424 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810