DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and hipk1a

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	XP_021325698.1	Gene:	hipk1a / 572042	ZFINID:	ZDB-GENE-081031-101	Length:	1125	Species:	Danio rerio

Alignment Length:	535	Identity:	136/535 - (25%)
Similarity:	233/535 - (43%)	Gaps:	112/535 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1553 YAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTN-TQLFYASPA-------- 1608
            :|:...||.....|   .||..:|...:|....|       ::|:.| :.|.:..|.
Zfish    29 HAWNVSNQSGESSY---YQHSPSQTNGSSPSTSG-------FNPSYNSSSLVFPPPGASREQTVV 83

  Fly  1609 ----SSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFI-ETA 1668
                |:.|..:|............:.:.:.|......|.|.:...::::|...|:..:..: |.:
Zfish    84 RAADSTGSGPEPSSSSSSSSTSSHRGKDARSNSLTCEGYQKRASLKRKSEEVDSSDSVQILEELS 148

  Fly  1669 KPVIQD-------DADGHLIYHT------------GD--ILHHR--------YKIMATLGEGTFG 1704
            .||:.:       :|....|.|:            ||  ::.|.        |:::..||.||||
Zfish   149 APVLPNRVAGGGGNATAQSIAHSTSTTKSSNSHSEGDYQLVQHEILCSVSNSYEVLEFLGRGTFG 213

  Fly  1705 RVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCI 1769
            :|.|......:..:|:||:||...|....::|::.|.:::.::.. :...|:..:.|.:..|.|:
Zfish   214 QVAKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILSRLSTENAD-EFNFVRSYECFQHKNHTCL 277

  Fly  1770 VFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSH 1834
            |||||..:::|||:.:.:.|..|..:|.:..|:..::..|....|.|.|||||||:.||
Zfish   278 VFEMLEQNLYDFLKHSKFSPLLLKCIRPVLQQVSTALMKLKSLGLIHADLKPENIMLVD------ 336

  Fly  1835 YNHKINREVRRVKNTDVRLIDFGSATFDHEHH------STIVSTRHYRAPEVILELGWSQPCDVW 1893
               .|.:..|      |::||||||:     |      ||.:.:|:|||||:||.|.:.:..|:|
Zfish   337 ---PIRQPYR------VKVIDFGSAS-----HVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMW 387

  Fly  1894 SIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLD----- 1953
            |:||::.||:||..|:......:.:..:.:..|     :...:.|.:.|||..|:|...|
Zfish   388 SLGCVIAELFLGWPLYPGASEYDQIRYISQTQG-----LPAEYLLSAGTKTSRFFHRGPDSSYPL 447

  Fly  1954 WDEKSSA------GRYVRDHCKPLFLCQ----------------LSDSEDHCELFSLIKKMLEYE 1996
            |..|:.|      |...::..|.:|.|.                |::..|..|...|:||||..:
Zfish   448 WRLKTPAEHEAEFGIKSKEARKYIFNCLDDMMQVNMTNLEGTDILAEKADRREFIDLLKKMLTLD 512

  Fly  1997 PSSRITLGEALHHPF 2011
            ...|||..:.|:|||
Zfish   513 ADKRITPTKTLNHPF 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	111/388 (29%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	106/353 (30%)
hipk1a	XP_021325698.1	STKc_HIPK	201..528	CDD:271113	106/353 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900