DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and hipk3a

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	XP_021326178.1	Gene:	hipk3a / 564413	ZFINID:	ZDB-GENE-061207-54	Length:	1276	Species:	Danio rerio

Alignment Length:	543	Identity:	144/543 - (26%)
Similarity:	245/543 - (45%)	Gaps:	116/543 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1546 PLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAG-LQY-------------DP 1596
            ||..|:.....||...:... :|.:..|....:.||:......:.| |||             |.
Zfish    57 PLLRFEALTSEKPCPARNFS-KQTESAPQELLRRASSPYNRVASEGKLQYFSKAEVGVEEKSGDS 120

  Fly  1597 NTNTQLFYASPASSSSNKQPQQPQQQQQQ----------------QQSQLQQSNSVIFNHSGQQH 1645
            ..|:|     .:|.||...|:..:::::.                :..:::.|.|::  ...::|
Zfish   121 GQNSQ-----GSSRSSGGAPEGVRRKERSGGLNSDEGTQKCGFKCKGQEIENSKSIM--QIVEEH 178

  Fly  1646 Q--PHQQQQNEMSKSALGLHFIE---TAKPVIQDDADG--HLIYHTGDIL---HHRYKIMATLGE 1700
            .  |.....|..|.:|:|:...|   |....:....||  .|:.|  ::|   .|.|:::..||.
Zfish   179 STLPAMLPTNVGSTTAVGVAPPEQKGTGTGAVNGTGDGDYQLVQH--EVLCSMKHTYEVLEFLGR 241

  Fly  1701 GTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHG 1765
            ||||:|||......:..:|:||:||...|....::|::.|.:::.::.. :|..|:..:.|.:..
Zfish   242 GTFGQVVKCWKRGTNEIVAVKILKNHPSYARQGQIEVSILARLSGENAE-EHNLVRAFECFQHRS 305

  Fly  1766 HMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSD 1830
            |.|:|||||..:::|||::|.:.|.||..:|.:..|:..::|.|....|.|.|||||||:.||
Zfish   306 HTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVD-- 368

  Fly  1831 YTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHH------STIVSTRHYRAPEVILELGWSQP 1889
                   .:.:..|      |::||||||:     |      ||.:.:|:|||||:||.|.:.:.
Zfish   369 -------PVRQPFR------VKVIDFGSAS-----HVSKAVCSTYLQSRYYRAPEIILGLPFCEA 415

  Fly  1890 CDVWSIGCILFELYLGITLFQ---THDNREHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGK 1951
            .|:||:||::.||:||..|:.   .:|...:::..:.:.|:        ..|...|||..|:..:
Zfish   416 IDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGE--------QLLNVGTKTARFFCKE 472

  Fly  1952 LD-----W------DEKSSAGRYVRDHCKPLFLC-----------------QLSDSEDHCELFSL 1988
            .|     |      :.::..|...::..|.:|.|                 ||::..|..|...|
Zfish   473 SDSPYTAWRLKTTEEHEAETGLKSKEARKYIFSCLDDIGHVNLMLNMEGCDQLAEKADRREFVDL 537

  Fly  1989 IKKMLEYEPSSRITLGEALHHPF 2011
            :|.||..:...||...:||.|||
Zfish   538 LKMMLMIDADQRIAPSDALTHPF 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	112/373 (30%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	108/357 (30%)
hipk3a	XP_021326178.1	PKc_like	232..561	CDD:328722	108/358 (30%)
		NUT	601..>737	CDD:315542
		Atrophin-1	<970..1274	CDD:331285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810