DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and clk2a

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_001038344.1	Gene:	clk2a / 558981	ZFINID:	ZDB-GENE-030131-298	Length:	526	Species:	Danio rerio

Alignment Length:	584	Identity:	275/584 - (47%)
Similarity:	368/584 - (63%)	Gaps:	78/584 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1482 LTHSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQ-----------------HQHSSFGVG 1529
            :.||..:.|::|.:...:..:::::...:.:.:.|:.::                 .|.:.:.
Zfish     1 MPHSRRYPSSERASRSSYQDRYRERDRDRDRGRKPRHRRSPTYSSSSERERRARGHRQDTGYA-- 63

  Fly  1530 MMSRNYYNMPKQPERKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQY 1594
             .||:|.|  :..:|:|.......:|.:.:..:.....|.:.|                     .
Zfish    64 -RSRSYDN--RSSDRRPYDRHYGESYRRLDHSRERDRDQNRDH---------------------R 104

  Fly  1595 DPNTNTQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSA 1659
            .|:.    :|:..||.|.:.:..:.:.::..            :...|.:.:..::::...|.||
Zfish   105 TPSN----YYSRDASPSYDFRRGRDRDREDS------------YRRKGSRRKHKRRRRRTRSYSA 153

  Fly  1660 LGLHFIETAKPV-IQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYC-MALKI 1722
            .........:.: ::||.:||||..:||:|..||:|::||||||||||::..|..|... :||||
Zfish   154 SSSRSDSGTRALCVRDDEEGHLICRSGDVLQERYEIVSTLGEGTFGRVMQCIDHRRGGAHVALKI 218

  Fly  1723 IKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNY 1787
            |||||||:|||:||||.||:|.:|||..::|||:|.|||||||||||.||:|.||.||||:||||
Zfish   219 IKNVEKYKEAARLEINVLERINEKDPENNNLCVQMFDWFDYHGHMCISFELLALSTFDFLKENNY 283

  Fly  1788 EPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVR 1852
            .||.::||||||||:|.:|||||:|:||||||||||||||:||||..||.:..|:.|.||||.||
Zfish   284 LPYSINQVRHMAYQVCLAVKFLHENKLTHTDLKPENILFVNSDYTVTYNVEKKRDERTVKNTAVR 348

  Fly  1853 LIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREH 1917
            ::||||||||||||||||||||||||||||||||||||||||||.||||.|||.|||||||||||
Zfish   349 VVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGSILFEYYLGFTLFQTHDNREH 413

  Fly  1918 LAMMERILGQIPYRMARNHTLYSKT-KTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSED 1981
            |||||||||.:|.||.|      || |.||||.|:|||||.||||||||::||||....||::|:
Zfish   414 LAMMERILGPVPSRMIR------KTRKQKYFYRGRLDWDENSSAGRYVRENCKPLRRYLLSEAEE 472

  Fly  1982 HCELFSLIKKMLEYEPSSRITLGEALHHPFFDRLPPHHRVGEVSNKQPLSSGSSSRERSHSLSR 2045
            |.:||.||:.|||||||.|:||..||.||||.        ..:|:.: ||:| .|.|.:..:||
Zfish   473 HHQLFDLIEAMLEYEPSKRLTLAAALRHPFFQ--------SGISSSE-LSAG-KSWEANRDISR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	238/334 (71%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	231/321 (72%)
clk2a	NP_001038344.1	DUF1777	34..>117	CDD:285811	15/112 (13%)
		PRP38_assoc	<37..104	CDD:289628	10/92 (11%)
		PKc_CLK2	174..503	CDD:271117	238/334 (71%)
		S_TKc	187..503	CDD:214567	231/321 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595352
Domainoid	1	1.000	477	1.000	Domainoid score	I403
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H33303
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	1	1.000	-	-		otm25346
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	LDO	PTHR45646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R660
SonicParanoid	1	1.000	-	-		X440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.870