DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doa and clk4b

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_001316837.1	Gene:	clk4b / 503607	ZFINID:	ZDB-GENE-050227-19	Length:	479	Species:	Danio rerio

Alignment Length:	533	Identity:	227/533 - (42%)
Similarity:	318/533 - (59%)	Gaps:	90/533 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1484 HSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKPLQ 1548
            |.:.....:|......|.:..::.|:..::...::::.:.:|     :..:.|.....|.|:..:
Zfish    31 HRSRSGERERQPGQTHHYKTYERCHISSKRLECRERRAREAS-----LEHSRYKGRVDPVRETER 90

  Fly  1549 TFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSN 1613
            ..|.|.|.:....:..:..:.:||.|                             :.||.|.|
Zfish    91 EKDGYHYSQSRSGRSRRSSRARQHSH-----------------------------HRSPGSDS-- 124

  Fly  1614 KQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFIETAKPVIQDDADG 1678
                                            :.|::::   :||             |:||.:|
Zfish   125 --------------------------------RSHRRKR---TKS-------------IEDDEEG 141

  Fly  1679 HLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMER-DYCMALKIIKNVEKYREAAKLEINALEK 1742
            ||:||.||:|..||:|:.|||||.||:||:..|..: :..:|||||||:|:|||||..|::.||:
Zfish   142 HLVYHNGDMLRARYEIVGTLGEGAFGKVVECLDHTKGNVRVALKIIKNIERYREAALSEVDVLER 206

  Fly  1743 IAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVK 1807
            |...|......||:|:||||:|||:|||||:||||.:|||:||.:.|:.|.|:||||.|:..:|:
Zfish   207 INSLDDEKRFACVRMLDWFDHHGHICIVFELLGLSTYDFLKENGFMPFSLTQIRHMADQIFRAVR 271

  Fly  1808 FLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVST 1872
            |||.|:||||||||||||||||:|...||.::.|:.|.:|..||:::|||:||:|||||:::|||
Zfish   272 FLHKNKLTHTDLKPENILFVDSNYDIKYNSRMKRDERTLKRLDVKVVDFGNATYDHEHHTSVVST 336

  Fly  1873 RHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARNHT 1937
            ||||||||||||||:|.|||||:||||.|.|||:|||||||::|||||||::||.||     .|.
Zfish   337 RHYRAPEVILELGWNQACDVWSLGCILVEFYLGLTLFQTHDSKEHLAMMEKVLGPIP-----THL 396

  Fly  1938 LYSKTKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRIT 2002
            |....|.:|.:|.||||||.||||||||.|||||.....|.:.:|..||.|::||:||:.|.|||
Zfish   397 LQKTKKRRYVHHDKLDWDEHSSAGRYVRKHCKPLKQYMSSKTPEHELLFDLLQKMMEYDSSKRIT 461

  Fly  2003 LGEALHHPFFDRL 2015
            |.:|:.||||:.|
Zfish   462 LEQAIGHPFFNPL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	199/333 (60%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	191/320 (60%)
clk4b	NP_001316837.1	PKc_like	142..471	CDD:304357	199/333 (60%)
clk4b	NP_001316837.1	S_TKc	155..471	CDD:214567	191/320 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	O	PTHR45646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R660
SonicParanoid	1	1.000	-	-		X440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.800