DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and Clk2

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	XP_008759408.1	Gene:	Clk2 / 365842	RGDID:	1359711	Length:	540	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	279/561 - (49%)
Similarity:	367/561 - (65%)	Gaps:	76/561 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1482 LTHSASFSSAQRPTALQFHQQHQQQQHLQQ------------QQQHPQQQQHQHSSFGVGMMSRN 1534
            :.|...:.|::|.:...:|:.::.::|.::            :::..:...|..|..|. ::|.:
  Rat    34 MPHPRRYHSSERGSRGSYHEHYRSRKHKRRRSRSWSSTSDRTRRRRREDSYHVRSRSGY-LLSNS 97

  Fly  1535 YYNMPKQPERKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTN 1599
            .|:......|    .:| ..|....:.......:.:.:..|.|:::           .:|....:
  Rat    98 SYDDHSSDRR----LYD-RRYCGSYRRNDYSRDRGEAYYDTDFRHS-----------YEYHRENS 146

  Fly  1600 TQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHF 1664
            :   |.|..||.     ::|::::::.::         |:||..||      .:..:||
  Rat   147 S---YRSQRSSR-----RKPRRRRRRSRT---------FSHSSSQH------SSRRAKS------ 182

  Fly  1665 IETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYC-MALKIIKNVEK 1728
                   ::|||:||||||.||.|..||:|::|||||||||||:..|..|... :||||||||||
  Rat   183 -------VEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEK 240

  Fly  1729 YREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLD 1793
            |:|||:||||.||||.:|||...:|||:|.|||||||||||.||:||||.||||::|||.|||:.
  Rat   241 YKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIH 305

  Fly  1794 QVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGS 1858
            ||||||:|||.:|||||||:||||||||||||||:|||...||.:..|:.|.||:|.||::||||
  Rat   306 QVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGS 370

  Fly  1859 ATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMER 1923
            ||||||||||||||||||||||||||||||||||||||||:||.|:|.|||||||||||||||||
  Rat   371 ATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMER 435

  Fly  1924 ILGQIPYRMARNHTLYSKT-KTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFS 1987
            |||.:|.||.|      || |.||||.|:|||||.:|||||||::||||.....|::|||.:||.
  Rat   436 ILGPVPSRMIR------KTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHHQLFD 494

  Fly  1988 LIKKMLEYEPSSRITLGEALHHPFFDRL---PPHHRVGEVS 2025
            ||:.||||||:.|:||||||.||||..|   ||:.::.:.|
  Rat   495 LIENMLEYEPAKRLTLGEALQHPFFACLRTEPPNTKLWDSS 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	241/334 (72%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	232/321 (72%)
Clk2	XP_008759408.1	PKc_CLK2	190..519	CDD:271117	241/334 (72%)
Clk2	XP_008759408.1	S_TKc	203..519	CDD:214567	232/321 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353258
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H33303
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	1	1.000	-	-		otm44882
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	LDO	PTHR45646
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X440
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.740