Protein Alignment Doa and madd-3

DIOPT Version :10

• Sequence 1: NP_001014681.2
• Gene: Doa / 43415
• FlyBaseID: FBgn0265998
• Length: 2045
• Species: Drosophila melanogaster
• Sequence 2: NP_001368709.1
• Gene: madd-3 / 3565068
• WormBaseID: WBGene00006517
• Length: 890
• Species: Caenorhabditis elegans
• Alignment Length: 1101
• Identity: 354/1101 - (32%)
• Similarity: 486/1101 - (44%)
• Gaps: 279/1101 - (25%)

  Fly  1001 VLPKSMSMTHVPGGGQPMGAPL-LRTSSRTHIP---SYMKNLPSLSRSTSNSAIL---MTQPRKE 1058
            :|.:.::.|    ||||....| ||......||   .| ||..|..|:|...|.|   ::.|...
 Worm     3 ILHQKIAST----GGQPSTNSLALRRLPLVVIPRKRKY-KNYVSRRRNTQLLASLRRCVSDPNVY 62

  Fly  1059 PP---------PKEPLKAPAPLPAIAAPTVGKPSGVLKSSSSSCVPSPRCAAAFFRRPQEANNPQ 1114
            ..         |..|:|:.||.|....|                :|.|:..      |.:...|.
 Worm    63 KSYNHWKALLRPMTPIKSGAPTPKTVTP----------------MPVPQIP------PHQKMTPN 105

  Fly  1115 QQHHQ-PLQKPQQVAPIEESGPGDSASLERKSEKSNSTLSTSSFTVTNCCTTHLPQLSKFTSSFH 1178
            ....| |:|.|...|..|:  |||..|.........|....|:..:....|...|.||
 Worm   106 PTPTQNPVQLPLPHAVSEK--PGDKKSTGPTPSPVPSKAPISAAKLPGTVTKVAPLLS------- 161

  Fly  1179 IAPTTATTTAATATPTPTGAATTSDQQQQSGGTPAMVAANLEVPTSSSSSAATKRQKDVDNKLEK 1243
                .|.....|..|.|..:.|.|.    ||.....|:..|....|.:.:...|.:|.|
 Worm   162 ----AAQPPPKTLAPAPGASETNSG----SGPVSKQVSGKLTELKSKNGTVTEKTEKAV------ 212

  Fly  1244 CLNDMLKLKTSSNNNSTSNSNNNAIMSHSLTGEHKDPKTALEGPTSSSSSSSSKYI------GES 1302
                 |::.:|::..:         .:.|......:|...   ||::..|..:..|      ..:
 Worm   213 -----LRIPSSASTRA---------KAASAVAPEANPAPV---PTATKPSPFAPAIAPLRDGAPA 260

  Fly  1303 QIPVPVQLYDPQKPLLQQQQQQQRICYPIGKSNSTSQLPMGGYQRLLQHQQQQHHQQQQQQHQEQ 1367
            |.|.|:|...|.:|             |:.|.||.
 Worm   261 QPPAPIQASAPLRP-------------PVAKQNSL------------------------------ 282

  Fly  1368 QQYPQHKRPFLNWNSFACSAMNGASDPFMQQQHMPAHQQQQHLPHKLQQSYSSSHVPKQAPKSGL 1432
            |:.|:.||..            ||          |.......|.:|:               .|:
 Worm   283 QKPPEPKRSV------------GA----------PPKALPSELVNKI---------------DGI 310

  Fly  1433 AMFLQKNTNKENKFGQPMQQQPPG--MMPQMYGYQAPQQQSKIGYPRTGAPLTHSASFSSAQRPT 1495
            . ||.:::|:....||.......|  .:.:.||.::......||.|          :..|..:|
 Worm   311 E-FLPQSSNQNTDDGQQPTTSTGGAKALRRAYGSKSGTTICAIGSP----------NVPSTSQP- 363

  Fly  1496 ALQFHQQHQQQQHLQQQQQHPQQQQ--------------HQHSSFGVGMMS-----RNYYNMPKQ 1541
                 ||...::.|.:::...::::              ...|...:|:.|     .|..|..:.
 Worm   364 -----QQGDNEKRLIEKKLSLRKKKLSGEGVPPAGSMLTGSKSGVEIGLSSNLTTTNNNNNKEQT 423

  Fly  1542 PERKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYAS 1606
            .|::..:|.:..|.....|                        .|.|.|....||        ||
 Worm   424 DEQRAKKTVNAVAAAFSTQ------------------------AGSGNATTVDDP--------AS 456

  Fly  1607 PASSSSNKQPQQPQQQQQQQQ---SQLQQSNSVIF---------------NHSGQQHQPHQQQQN 1653
            ..:|..|...|.|:.:....|   ||||...||..               :.||.|....:.:..
 Worm   457 TTTSKENPAAQPPKPKSAAVQNLISQLQLPASVSAKVDKIIACGDKARKPSRSGLQASQARPKVP 521

  Fly  1654 EMSKSALGLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYCM 1718
            |:..|....|         |||.||||||..||.:.:|:.|..||||||||:||:|.|...|..|
 Worm   522 EIVSSQRTQH---------QDDKDGHLIYSKGDFILNRFTIYDTLGEGTFGKVVRVNDSLSDTFM 577

  Fly  1719 ALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLR 1783
            ||||||||.|||||||||:..|:|:|:|||...:..:.|..:|||:||:|::|:::|.|:||||:
 Worm   578 ALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFDYNGHICLLFDLMGSSIFDFLK 642

  Fly  1784 ENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKN 1848
            .|:|:|||::|..|:.:|||.:|||||||:||||||||||||||||.||:....|  :.:|.:.:
 Worm   643 ANHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTTKLVDK--KPLRVLHS 705

  Fly  1849 TDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHD 1913
            |.|||||||||||||||||.|||||||||||||||||||||||||||||||:|||.|:||||||:
 Worm   706 THVRLIDFGSATFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHE 770

  Fly  1914 NREHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSD 1978
            ||||||||||:||.||.|||:....:   :||:|.:|:|||...|:...||||:||||.......
 Worm   771 NREHLAMMERVLGDIPLRMAKRTNTF---RTKFFINGRLDWVNTSADAAYVRDNCKPLRRSMSCT 832

  Fly  1979 SEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDRLPPHHRVGEVSNKQPLSSGSSSRER 2039
            ..:|.|||.||:.||.:||.:|:.|.|||.|.:|:|||.:.::       |....:|:..|
 Worm   833 DPEHVELFELIENMLMFEPLARMKLPEALQHRYFNRLPENLKI-------PCKMDASTNPR 886

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PHA03247	<205..634	CDD:223021
		PKc_CLK	1679..2012	CDD:271036	204/332 (61%)
madd-3	NP_001368709.1	PHA03247	<73..364	CDD:223021	82/449 (18%)
		PKc_CLK	538..866	CDD:271036	204/332 (61%)