DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and madd-3

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_001368709.1	Gene:	madd-3 / 3565068	WormBaseID:	WBGene00006517	Length:	890	Species:	Caenorhabditis elegans

Alignment Length:	1101	Identity:	354/1101 - (32%)
Similarity:	486/1101 - (44%)	Gaps:	279/1101 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1001 VLPKSMSMTHVPGGGQPMGAPL-LRTSSRTHIP---SYMKNLPSLSRSTSNSAIL---MTQPRKE 1058
            :|.:.::.|    ||||....| ||......||   .| ||..|..|:|...|.|   ::.|...
Worm     3 ILHQKIAST----GGQPSTNSLALRRLPLVVIPRKRKY-KNYVSRRRNTQLLASLRRCVSDPNVY 62

  Fly  1059 PP---------PKEPLKAPAPLPAIAAPTVGKPSGVLKSSSSSCVPSPRCAAAFFRRPQEANNPQ 1114
            ..         |..|:|:.||.|....|                :|.|:..      |.:...|.
Worm    63 KSYNHWKALLRPMTPIKSGAPTPKTVTP----------------MPVPQIP------PHQKMTPN 105

  Fly  1115 QQHHQ-PLQKPQQVAPIEESGPGDSASLERKSEKSNSTLSTSSFTVTNCCTTHLPQLSKFTSSFH 1178
            ....| |:|.|...|..|:  |||..|.........|....|:..:....|...|.||
Worm   106 PTPTQNPVQLPLPHAVSEK--PGDKKSTGPTPSPVPSKAPISAAKLPGTVTKVAPLLS------- 161

  Fly  1179 IAPTTATTTAATATPTPTGAATTSDQQQQSGGTPAMVAANLEVPTSSSSSAATKRQKDVDNKLEK 1243
                .|.....|..|.|..:.|.|.    ||.....|:..|....|.:.:...|.:|.|
Worm   162 ----AAQPPPKTLAPAPGASETNSG----SGPVSKQVSGKLTELKSKNGTVTEKTEKAV------ 212

  Fly  1244 CLNDMLKLKTSSNNNSTSNSNNNAIMSHSLTGEHKDPKTALEGPTSSSSSSSSKYI------GES 1302
                 |::.:|::..:         .:.|......:|...   ||::..|..:..|      ..:
Worm   213 -----LRIPSSASTRA---------KAASAVAPEANPAPV---PTATKPSPFAPAIAPLRDGAPA 260

  Fly  1303 QIPVPVQLYDPQKPLLQQQQQQQRICYPIGKSNSTSQLPMGGYQRLLQHQQQQHHQQQQQQHQEQ 1367
            |.|.|:|...|.:|             |:.|.||.
Worm   261 QPPAPIQASAPLRP-------------PVAKQNSL------------------------------ 282

  Fly  1368 QQYPQHKRPFLNWNSFACSAMNGASDPFMQQQHMPAHQQQQHLPHKLQQSYSSSHVPKQAPKSGL 1432
            |:.|:.||..            ||          |.......|.:|:               .|:
Worm   283 QKPPEPKRSV------------GA----------PPKALPSELVNKI---------------DGI 310

  Fly  1433 AMFLQKNTNKENKFGQPMQQQPPG--MMPQMYGYQAPQQQSKIGYPRTGAPLTHSASFSSAQRPT 1495
            . ||.:::|:....||.......|  .:.:.||.::......||.|          :..|..:|
Worm   311 E-FLPQSSNQNTDDGQQPTTSTGGAKALRRAYGSKSGTTICAIGSP----------NVPSTSQP- 363

  Fly  1496 ALQFHQQHQQQQHLQQQQQHPQQQQ--------------HQHSSFGVGMMS-----RNYYNMPKQ 1541
                 ||...::.|.:::...::::              ...|...:|:.|     .|..|..:.
Worm   364 -----QQGDNEKRLIEKKLSLRKKKLSGEGVPPAGSMLTGSKSGVEIGLSSNLTTTNNNNNKEQT 423

  Fly  1542 PERKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYAS 1606
            .|::..:|.:..|.....|                        .|.|.|....||        ||
Worm   424 DEQRAKKTVNAVAAAFSTQ------------------------AGSGNATTVDDP--------AS 456

  Fly  1607 PASSSSNKQPQQPQQQQQQQQ---SQLQQSNSVIF---------------NHSGQQHQPHQQQQN 1653
            ..:|..|...|.|:.:....|   ||||...||..               :.||.|....:.:..
Worm   457 TTTSKENPAAQPPKPKSAAVQNLISQLQLPASVSAKVDKIIACGDKARKPSRSGLQASQARPKVP 521

  Fly  1654 EMSKSALGLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYCM 1718
            |:..|....|         |||.||||||..||.:.:|:.|..||||||||:||:|.|...|..|
Worm   522 EIVSSQRTQH---------QDDKDGHLIYSKGDFILNRFTIYDTLGEGTFGKVVRVNDSLSDTFM 577

  Fly  1719 ALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLR 1783
            ||||||||.|||||||||:..|:|:|:|||...:..:.|..:|||:||:|::|:::|.|:||||:
Worm   578 ALKIIKNVSKYREAAKLEVKVLQKLAEKDPEKKNWVIHMGSYFDYNGHICLLFDLMGSSIFDFLK 642

  Fly  1784 ENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKN 1848
            .|:|:|||::|..|:.:|||.:|||||||:||||||||||||||||.||:....|  :.:|.:.:
Worm   643 ANHYKPYPMEQTLHITWQLCNAVKFLHDNKLTHTDLKPENILFVDSRYTTKLVDK--KPLRVLHS 705

  Fly  1849 TDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHD 1913
            |.|||||||||||||||||.|||||||||||||||||||||||||||||||:|||.|:||||||:
Worm   706 THVRLIDFGSATFDHEHHSIIVSTRHYRAPEVILELGWSQPCDVWSIGCILYELYTGVTLFQTHE 770

  Fly  1914 NREHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSD 1978
            ||||||||||:||.||.|||:....:   :||:|.:|:|||...|:...||||:||||.......
Worm   771 NREHLAMMERVLGDIPLRMAKRTNTF---RTKFFINGRLDWVNTSADAAYVRDNCKPLRRSMSCT 832

  Fly  1979 SEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDRLPPHHRVGEVSNKQPLSSGSSSRER 2039
            ..:|.|||.||:.||.:||.:|:.|.|||.|.:|:|||.:.::       |....:|:..|
Worm   833 DPEHVELFELIENMLMFEPLARMKLPEALQHRYFNRLPENLKI-------PCKMDASTNPR 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	204/332 (61%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	197/319 (62%)
madd-3	NP_001368709.1	PHA03247	<73..364	CDD:223021	82/449 (18%)
madd-3	NP_001368709.1	PKc_CLK	538..866	CDD:271036	204/332 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166812
Domainoid	1	1.000	415	1.000	Domainoid score	I334
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H33303
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	1	1.000	-	-		oto20128
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	LDO	PTHR45646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.840