DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and lkh1

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_001018187.2	Gene:	lkh1 / 3361532	PomBaseID:	SPAC1D4.11c	Length:	690	Species:	Schizosaccharomyces pombe

Alignment Length:	788	Identity:	232/788 - (29%)
Similarity:	325/788 - (41%)	Gaps:	199/788 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1287 PTSSSSSS------------SSKYIGESQIPVPVQLYDPQKPLLQQQQQQQRICYPIGKSNSTSQ 1339
            |.||||.|            ::.|...:.:.:| |.|||..                 .:|....
pombe    58 PPSSSSPSTTGTVAVPINGANAVYPSTNSVSLP-QSYDPWL-----------------DANGVVP 104

  Fly  1340 LPMGGYQRLLQHQQQQHHQQQQQQHQEQQQYPQHKRPFLNWNSFACSAMNGASDPFMQQQHMPAH 1404
            ||              |.......:..|.....|          |||  |..| ||....|.|.|
pombe   105 LP--------------HDVASHPSYMVQSPTSYH----------ACS--NNQS-PFPHSHHPPLH 142

  Fly  1405 QQQQHLPHKLQQSYSSSHVPKQAPKSGLAMFLQKNTNKENKFGQPMQQQP-----------PGMM 1458
            ..   ||...|.......|| |.|.....:.|.    ..|...||:.:.|           |..:
pombe   143 NP---LPVSCQPVLRPPPVP-QVPSHWYPVSLP----SPNLPHQPISKPPVIPNLPKLQVHPNRL 199

  Fly  1459 P---QMYGYQAPQQQSKIGYPRTGAPLTHSASFSSAQRP-TALQFHQQHQQQQHLQQQQQHPQQQ 1519
            |   ..:.|.:|     ..||....|.|:..|......| ||:.                 |..|
pombe   200 PHPIHNHPYSSP-----TSYPPPLCPATYCPSNPPQLAPATAIA-----------------PSSQ 242

  Fly  1520 QHQHSSFGVGMMSRNYYNMPKQPERKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGG 1584
            ..||.|....:...:..|....|....|..:.|...|                   .||..||.
pombe   243 SSQHKSVNYSVTPSSINNHTAVPLSPTLAVWLPMTQP-------------------TFQPPSAN- 287

  Fly  1585 GGGGAAGLQYDPNTNTQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQ 1649
                    .|.|.:|... ..:|.|.|..:.|::.::.......::.:.|..:
pombe   288 --------VYQPASNANQ-VITPVSISDYRPPKKRKRAAWPPYKKVDRVNVPV------------ 331

  Fly  1650 QQQNEMSKSALGLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMER 1714
                        :|......|...||.|||..........:||.::..||.||||:|::..|...
pombe   332 ------------VHDTTAFDPSTFDDDDGHYKVVPNSKFANRYTVVRLLGHGTFGKVIQCYDQST 384

  Fly  1715 DYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVF 1779
            ....|:|:.:.:.|||||:.:|:..|:.||..||..::.|:::.|:|||..|:|||.::.|.|||
pombe   385 GRHCAIKVTRAIPKYREASLIELRVLQTIAHSDPTNENKCIQLRDYFDYRKHICIVTDLFGWSVF 449

  Fly  1780 DFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTS------HYNHK 1838
            |||:.|||.|:||..::.::.||..||.|||...|.||||||||:|.|.:...:      :|:.|
pombe   450 DFLKNNNYIPFPLKHIQMLSQQLFKSVAFLHSLGLVHTDLKPENVLLVSNASRTIRLPYRNYSQK 514

  Fly  1839 INREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELY 1903
            :      :.:.::||||||||||:.|:||::||||||||||:||.||||.|||||||||||.||:
pombe   515 V------LNSCEIRLIDFGSATFEDEYHSSVVSTRHYRAPEIILGLGWSYPCDVWSIGCILVELF 573

  Fly  1904 LGITLFQTHDNREHLAMMERILGQIPYRMARNHTLYSKTKTKYF-YHGKLDWDEKSSAGRYVRDH 1967
            .|..|||||::.|||.|||:|||.....|....   |:|..::| ..||:.:...::..:.:.
pombe   574 TGQALFQTHEDSEHLCMMEKILGPFDRNMISRS---SRTSQRFFKSDGKVRYPLSNTPKKSIN-- 633

  Fly  1968 CKPLFLCQLS--------DSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDRLPPHHRVGEV 2024
                :|..|.        .|.:...|..|:||:..|:|..|||..|||.||||
pombe   634 ----YLQSLQTLEQIFAVSSPEVALLLDLLKKVFVYDPKRRITAKEALWHPFF------------ 682

  Fly  2025 SNKQPLSS 2032
              .||:||
pombe   683 --TQPISS 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	146/347 (42%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	144/334 (43%)
lkh1	NP_001018187.2	E_Pc_C	<104..198	CDD:284226	28/128 (22%)
		PKc_CLK	349..682	CDD:271036	146/347 (42%)
		S_TKc	362..682	CDD:214567	144/334 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	279	1.000	Domainoid score	I304
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	1	1.000	-	-		oto100798
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	LDO	PTHR45646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R660
SonicParanoid	1	1.000	-	-		X440
TreeFam	1	0.960	-	-
	10	9.800