DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doa and dyrk1ab

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_001334760.1	Gene:	dyrk1ab / 327466	ZFINID:	ZDB-GENE-030131-5677	Length:	719	Species:	Danio rerio

Alignment Length:	512	Identity:	136/512 - (26%)
Similarity:	225/512 - (43%)	Gaps:	83/512 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1572 HPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQ---- 1632
            |.|.|:.:...          |....:.|.|.|:....:.:..|...||..:....:.|::
Zfish     7 HSHQQYSDCHQ----------QSTDQSVTVLPYSDQTQALTASQRHMPQCFRDPTLAPLRKLSID 61

  Fly  1633 -------SNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFIETAKPVIQ---DDADGHLIYHTGDI 1687
                   .|.|.:....::||..|.:.:...|.          :.|..   ||.:...:...|:.
Zfish    62 LIKTYKHINEVYYAKKKRRHQQGQGEDSSHKKE----------RKVFNDGYDDENYDYVVKNGEK 116

  Fly  1688 LHHRYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDH 1752
            ...||:|.:.:|:|:||:|||..|......:|:|||||.:.:...|::|:..||.:.:.|....:
Zfish   117 WMDRYEIDSLIGKGSFGQVVKAYDRAEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKY 181

  Fly  1753 LCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLT-- 1815
            ..|.:...|.:..|:|:|||||..:::|.||..|:....|:..|..|.|||.::.||....|:
Zfish   182 YIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLATPELSII 246

  Fly  1816 HTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEV 1880
            |.||||||||..:.                 |.:.::::||||:....:.....:.:|.||:|||
Zfish   247 HCDLKPENILLCNP-----------------KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEV 294

  Fly  1881 ILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARNHTLYSKTKTK 1945
            :|.:.:....|:||:||||.|::.|..||...:..:.:..:..:||..|     ||.:....|.:
Zfish   295 LLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPP-----NHIMDLAPKAR 354

  Fly  1946 YFYHGKLD--WD-EKSSAG-RYVRDHCKPLFL-----C------QLSDS----EDHCELFSLIKK 1991
            .|:....|  |. :|:..| ||.....:.|..     |      :..:|    .|:.:...||.:
Zfish   355 KFFEKLSDGTWSIKKTKDGKRYKPPASRKLHAILGVECGGPGGRRAGESGHAVADYLKFKDLILR 419

  Fly  1992 MLEYEPSSRITLGEALHHPFFDRLPPH--HRVGEVSN----KQPLSSGSSSRERSHS 2042
            ||:|:|.:||....||.|.||.:....  :....||.    :|..|||::|...|.|
Zfish   420 MLDYDPKTRIQPYYALQHSFFKKTTDEGTNTSSSVSTSPALEQSQSSGTTSSTSSSS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	105/353 (30%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	103/340 (30%)
dyrk1ab	NP_001334760.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810