DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Doa and clk4a

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	XP_003199888.1	Gene:	clk4a / 321857	ZFINID:	ZDB-GENE-030131-576	Length:	496	Species:	Danio rerio

Alignment Length:	527	Identity:	227/527 - (43%)
Similarity:	328/527 - (62%)	Gaps:	65/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1497 LQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKPLQTFDPYAYPKPNQM 1561
            ::..::|::..| ..::::..::.|.|.....|      :.:.|:...:.|.|.:
Zfish    22 METRKRHRRDSH-SSERENKYRKHHHHYKNSDG------HCLEKRSSNERLDTSE---------- 69

  Fly  1562 QPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSNKQPQQPQQQQQQQ 1626
               |:...:.|.|           .|.||....:.|.:         .|.|.::.::.::.:...
Zfish    70 ---KHAVFRDHEH-----------NGYAACKDKERNRD---------RSRSRERHRERERDRDWH 111

  Fly  1627 QSQLQQSNSVIFNHSGQQHQ-----PHQQQQNEMSKSALGLHFIETAKPVIQDDADGHLIYHTGD 1686
            .......||:..:....:|:     ||...::...|.:..          ::||.:|||:||:||
Zfish   112 HYSKSSGNSMRSSRHRHRHRHRRSHPHSDSRSHRRKRSRS----------VEDDEEGHLVYHSGD 166

  Fly  1687 ILHHRYKIMATLGEGTFGRVVKVKDMER-DYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHC 1750
            :|..||:|:.|||||.||:||:..|.|: ...:|||||||:|:||:||..|:..||:|...|  |
Zfish   167 MLRARYEIVCTLGEGAFGKVVECIDHEKVGARIALKIIKNIERYRDAALSEVEVLEQINSLD--C 229

  Fly  1751 D--HLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNR 1813
            |  :.||:|.||||:|||:||.||:||||.:|||:|||::|:.::.:||||||:..:|:|||.|:
Zfish   230 DRRYACVRMYDWFDHHGHICIAFELLGLSTYDFLKENNFQPFYINHIRHMAYQIIRAVRFLHKNK 294

  Fly  1814 LTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAP 1878
            ||||||||||||||:|:|...||.|:.|:.|.|||.||:::|||:||::||||:::|||||||||
Zfish   295 LTHTDLKPENILFVNSEYNIRYNSKMKRDERTVKNPDVKVVDFGNATYEHEHHTSVVSTRHYRAP 359

  Fly  1879 EVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARNHTLYSKTK 1943
            ||||:||||..|||||:||||.|.|||.|||||||::||||||||:||.||     .|.|....|
Zfish   360 EVILDLGWSHSCDVWSVGCILIEYYLGSTLFQTHDSKEHLAMMERVLGPIP-----THMLQKTRK 419

  Fly  1944 TKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALH 2008
            :::..:.|||||..||:|||||..||||....:|.|.||.:||.||::||||:.:.||||.||:.
Zfish   420 SRFVRNDKLDWDIHSSSGRYVRKQCKPLRQYLVSSSSDHEQLFDLIERMLEYDVTKRITLDEAIK 484

  Fly  2009 HPFFDRL 2015
            ||||:.:
Zfish   485 HPFFNSI 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	199/335 (59%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	191/322 (59%)
clk4a	XP_003199888.1	PKc_like	159..488	CDD:304357	199/335 (59%)
clk4a	XP_003199888.1	S_TKc	172..488	CDD:214567	191/322 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	1	1.000	-	-		otm25346
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	O	PTHR45646
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.770