DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and HIPK2

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	XP_011514379.1	Gene:	HIPK2 / 28996	HGNCID:	14402	Length:	1377	Species:	Homo sapiens

Alignment Length:	696	Identity:	175/696 - (25%)
Similarity:	277/696 - (39%)	Gaps:	164/696 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1402 PAHQQQQHLPHKLQQSYSSSHVP--KQ--APKSGLAMFLQKNTNKENKFGQPMQQQPP------- 1455
            |...|.:|.....:.:.|..::|  ||  .|...|..:.     .|.:.|....:.|.
Human    88 PGRYQAKHAAGTERVTASLIYLPQIKQTLTPALNLGWYF-----TEGQKGSISAEGPSVRFAWDL 147

  Fly  1456 -GMMPQMYGYQAPQQQSKI---------GYPRTGAPLTHSASFSSAQRPTALQFHQQHQQQQHLQ 1510
             |.:...:|.|....::|.         ..|....||...||                    |:|
Human   148 WGTLHDSWGLQEATLENKCQVLKRLNIESPPDLAVPLPGMAS--------------------HVQ 192

  Fly  1511 QQQQHPQQQQHQHSSF-----------------GVGMMSRNYYNMPKQPERKPLQTFDPYAYPKP 1558
            ....|..|.    |:|                 |.|..|:.|......|..:|..|....:.|.|
Human   193 VFSPHTLQS----SAFCSVKKLKIEPSSNWDMTGYGSHSKVYSQSKNIPLSQPATTTVSTSLPVP 253

  Fly  1559 NQMQPVKYQQQQQHP----HTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSNKQPQQP 1619
            |...|  |:|....|    |....:||:....|...|..::      |...|..|....
Human   254 NPSLP--YEQTIVFPGSTGHIVVTSASSTSVTGQVLGGPHN------LMRRSTVSLLDT------ 304

  Fly  1620 QQQQQQQQSQLQQSNSVIFNHSG----QQHQPHQQQQNEMSKSALGLHFIETA---KPVIQDDAD 1677
                 .|:..|::.:..|.|.|.    ::|.|  ..||..|.:.:......||   ......:.|
Human   305 -----YQKCGLKRKSEEIENTSSVQIIEEHPP--MIQNNASGATVATATTSTATSKNSGSNSEGD 362

  Fly  1678 GHLIYHTGDIL---HHRYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINA 1739
            ..|:.|  ::|   .:.|:::..||.||||:|||......:..:|:||:||...|....::|::.
Human   363 YQLVQH--EVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSI 425

  Fly  1740 LEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCY 1804
            |.:::.:... |:..|:..:.|.:..|.|:|||||..:::|||::|.:.|.||..:|.:..|:..
Human   426 LARLSTESAD-DYNFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPVLQQVAT 489

  Fly  1805 SVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHH--- 1866
            ::..|....|.|.|||||||:.||.          :|:..|||     :||||||:     |
Human   490 ALMKLKSLGLIHADLKPENIMLVDP----------SRQPYRVK-----VIDFGSAS-----HVSK 534

  Fly  1867 ---STIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQI 1928
               ||.:.:|:|||||:||.|.:.:..|:||:||::.||:||..|:......:.:..:.:..|
Human   535 AVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQG-- 597

  Fly  1929 PYRMARNHTLYSKTKTKYFYHGKLD-----W------DEKSSAGRYVRDHCKPLFLC-------- 1974
               :...:.|.:.|||..|::...|     |      |.::..|...::..|.:|.|
Human   598 ---LPAEYLLSAGTKTTRFFNRDTDSPYPLWRLKTPDDHEAETGIKSKEARKYIFNCLDDMAQVN 659

  Fly  1975 ---------QLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPF 2011
                     .|.:..|..|...|:||||..:...|||..|.|:|||
Human   660 MTTDLEGSDMLVEKADRREFIDLLKKMLTIDADKRITPIETLNHPF 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	113/370 (31%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	110/354 (31%)
HIPK2	XP_011514379.1	STKc_HIPK2	362..716	CDD:271129	114/372 (31%)
HIPK2	XP_011514379.1	S_TKc	378..706	CDD:214567	110/354 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810