Protein Alignment Doa and Dyrk3

DIOPT Version :9

• Sequence 1: NP_001014681.2
• Gene: Doa / 43415
• FlyBaseID: FBgn0265998
• Length: 2045
• Species: Drosophila melanogaster
• Sequence 2: NP_663483.1
• Gene: Dyrk3 / 226419
• MGIID: 1330300
• Length: 586
• Species: Mus musculus
• Alignment Length: 621
• Identity: 156/621 - (25%)
• Similarity: 267/621 - (42%)
• Gaps: 165/621 - (26%)

  Fly  1516 PQQQQHQHSSFGVGMMSRNYYNMPKQPERKPLQTFDPYA--YPKPNQMQPVKYQ-----QQQQHP 1573
            |||::.....:...||    .:..|.|         ||:  :..|:: .||..:     :.....
Mouse    22 PQQRRLGDGVYDTFMM----IDETKGP---------PYSDTFSNPSE-APVSRRLNITTEPLTRG 72

  Fly  1574 HTQ-FQNAS--------AGGGGGGAAGLQYDPNTNTQLFYASPASSSSNKQ-------------- 1615
            ||| |.|.|        ...|...:..||.|..:|::  .:||||...:.:
Mouse    73 HTQHFVNGSEMKVEQLFQEFGNRRSNTLQSDGISNSE--KSSPASQGKSSESLSAVKCNLSSRPS 135

  Fly  1616 ---PQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSALGLHFI----ETAKPVI- 1672
               |..|:|..:|            :.|    |....::...:|...  ::|:    :..:.||
Mouse   136 KVLPLTPEQALKQ------------YKH----HLTAYEKLEIVSYPE--IYFVGPNAKKRQGVIG 182

  Fly  1673 ------QDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYRE 1731
                  .|||||..|:...|.|.:||:::..:|:|:||:|.:|.|.:....:|||:::|.:::..
Mouse   183 GPNNGGYDDADGAYIHVPRDHLAYRYEVLKIIGKGSFGQVARVYDHKLRQYVALKMVRNEKRFHR 247

  Fly  1732 AAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVR 1796
            .|..||..||.:.::|.......:.|::.|.:..|:|:.||:|.:.:::.:::|.::.:.:..||
Mouse   248 QAAEEIRILEHLKKQDKTGSMNVIHMLESFTFRNHVCMAFELLSIDLYELIKKNKFQGFSVQLVR 312

  Fly  1797 HMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATF 1861
            ..|..:..|:..||.|::.|.||||||||.      .|:.           .:..::|||||:.|
Mouse   313 KFAQSILQSLDALHKNKIIHCDLKPENILL------KHHG-----------RSATKVIDFGSSCF 360

  Fly  1862 DHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILG 1926
            :::...|.:.:|.|||||:||...:|.|.|:||.||||.||..|..||...|..:.||.|..:||
Mouse   361 EYQKLYTYIQSRFYRAPEIILGCRYSTPIDIWSFGCILAELLTGQPLFPGEDEGDQLACMIELLG 425

  Fly  1927 QIPYRMARNHTLYSKTKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSED---------- 1981
            ..|.::     |....:.|||.:.|       ...||          |.:|...|
Mouse   426 MPPQKL-----LEQSKRAKYFINSK-------GLPRY----------CSVSTQTDGRVVLLGGRS 468

  Fly  1982 -------------------HC--ELF-SLIKKMLEYEPSSRITLGEALHHPF----------FDR 2014
                               .|  .|| ..:|:.|:::||:|:|..:||.||:          .|:
Mouse   469 RRGKKRGPPGSKDWATALKGCGDYLFIEFLKRCLQWDPSARLTPAQALRHPWISKSTPKPLTMDK 533

  Fly  2015 LP------PHHRVGEVSNKQPLSSGSSSRERSHSLS 2044
            :|      |.:....:.:|.|...|.:|:.:::.:|
Mouse   534 VPGKRVVNPTNAFQGLGSKLPPVVGIASKLKANLMS 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	106/374 (28%)
		S_TKc	1692..2012	CDD:214567	102/361 (28%)
Dyrk3	NP_663483.1	Disordered. /evidence=ECO:0000250|UniProtKB:O43781	1..187		37/198 (19%)
		PKc_DYRK2_3	142..521	CDD:271126	120/435 (28%)
		S_TKc	208..521	CDD:214567	102/351 (29%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O43781	467..480		0/12 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810