DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and DYRK1A

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_001387.2	Gene:	DYRK1A / 1859	HGNCID:	3091	Length:	763	Species:	Homo sapiens

Alignment Length:	612	Identity:	154/612 - (25%)
Similarity:	256/612 - (41%)	Gaps:	151/612 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1484 HSASFSSAQRPTALQ------FHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQP 1542
            |:...:||.:|::::      ||     ...||...|.|  ..||:|       .|...|:..|
Human     2 HTGGETSACKPSSVRLAPSFSFH-----AAGLQMAGQMP--HSHQYS-------DRRQPNISDQ- 51

  Fly  1543 ERKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTN-------- 1599
            :...|...|....|..||:.|.....|::.|.| |:                ||.|.
Human    52 QVSALSYSDQIQQPLTNQVMPDIVMLQRRMPQT-FR----------------DPATAPLRKLSVD 99

  Fly  1600 --------TQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMS 1656
                    .:::||              :::::.||.|...|:          |:..::..|:.
Human   100 LIKTYKHINEVYYA--------------KKKRRHQQGQGDDSS----------HKKERKVYNDG- 139

  Fly  1657 KSALGLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYCMALK 1721
                            .||.:...|...|:....||:|.:.:|:|:||:|||..|......:|:|
Human   140 ----------------YDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK 188

  Fly  1722 IIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENN 1786
            ||||.:.:...|::|:..||.:.:.|....:..|.:...|.:..|:|:|||||..:::|.||..|
Human   189 IIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTN 253

  Fly  1787 YEPYPLDQVRHMAYQLCYSVKFLHDNRLT--HTDLKPENILFVDSDYTSHYNHKINREVRRVKNT 1849
            :....|:..|..|.|:|.::.||....|:  |.||||||||..:.                 |.:
Human   254 FRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNP-----------------KRS 301

  Fly  1850 DVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDN 1914
            .::::||||:....:.....:.:|.||:|||:|.:.:....|:||:||||.|::.|..||...:.
Human   302 AIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANE 366

  Fly  1915 REHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLD--WD-EKSSAGRYVRDHCKPLFLCQL 1976
            .:.:..:..:||..|     .|.|....|.:.|:....|  |: :|:..|:  |:: ||....:|
Human   367 VDQMNKIVEVLGIPP-----AHILDQAPKARKFFEKLPDGTWNLKKTKDGK--REY-KPPGTRKL 423

  Fly  1977 SD--------------------SEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDRLPPH--H 2019
            .:                    ..|:.:...||.:||:|:|.:||....||.|.||.:....  :
Human   424 HNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTADEGTN 488

  Fly  2020 RVGEVSN----KQPLSSGSSSRERSHS 2042
            ....||.    :|..|||::|...|.|
Human   489 TSNSVSTSPAMEQSQSSGTTSSTSSSS 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	104/357 (29%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	101/344 (29%)
DYRK1A	NP_001387.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..57		8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..136		5/30 (17%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		5/26 (19%)
		PKc_DYRK1	148..484	CDD:271128	106/360 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..442		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..540		9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..679
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	744..763
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810