Protein Alignment Doa and mbk-1

DIOPT Version :9

• Sequence 1: NP_001014681.2
• Gene: Doa / 43415
• FlyBaseID: FBgn0265998
• Length: 2045
• Species: Drosophila melanogaster
• Sequence 2: NP_510460.2
• Gene: mbk-1 / 181578
• WormBaseID: WBGene00003149
• Length: 882
• Species: Caenorhabditis elegans
• Alignment Length: 824
• Identity: 201/824 - (24%)
• Similarity: 312/824 - (37%)
• Gaps: 228/824 - (27%)

  Fly  1289 SSSSSSSSKYIGESQIPVPV---------------QLYDPQKPLLQQQQQQQRICYPIGKSNSTS 1338
            |||.|::.::...:.:| |:               ||.|.|...||:||:||.
 Worm    18 SSSYSNTQQHSQMTNLP-PINHNNLCDTEPMNEDFQLQDVQADELQKQQKQQE------------ 69

  Fly  1339 QLPMGGYQRLLQHQQQQHHQ----QQQQQHQEQQQYPQHKRPFLNWNSFACSAMNGASDPFMQQQ 1399
                      .||.|||:.|    |.:|.|....::||.....:..||.|          |..||
 Worm    70 ----------QQHIQQQNAQRFIAQSRQPHSNILRFPQPPITSIKTNSHA----------FYPQQ 114

  Fly  1400 HMPAHQQQQHLPHKLQQSYSSSH---VPKQAPKSGLAMFLQKNTNKENKFGQ-PMQQQPPGMMPQ 1460
            .:     .|..|.|.:.|.:::.   .|...|        :|...|:...|| .....|.|:
 Worm   115 EV-----TQVRPKKHRVSMTNAEAALTPGMPP--------EKQAAKKRNIGQFSTDTVPAGI--- 163

  Fly  1461 MYGYQAPQQQSKIGYPRTGAPLTHSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSS 1525
                      ..||.|           |.|..:|..:             ||.::||.
 Worm   164 ----------GMIGIP-----------FESTSKPLQI-------------QQFRNPQD------- 187

  Fly  1526 FGVGMMSRNYYNMPKQPERKPLQTFDPY-AYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGA 1589
                           .|.||  .|.|.. .|...|:...::.|.::....:|......|...|..
 Worm   188 ---------------APVRK--LTSDLIKTYKAINESFYLRKQVRRDRHKSQDAGKPKGSKDGSG 235

  Fly  1590 AGLQYDPNTNT-QLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNS------VIFNHSGQQHQP 1647
            |.|     |:| .:..|.|.:||.|..    ||...|....|..:|:      |:     .....
 Worm   236 ASL-----TDTFSIHNAIPITSSDNHY----QQDAHQNAPPLLDTNAPPTSTMVV-----PMRTE 286

  Fly  1648 HQQQQNEMSKSALGLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMA--TLGEGTFGRVVKVK 1710
            ...||.:..||:.|..:...     .||.:...|...|:|...||.|::  .:|:|:||:|.|..
 Worm   287 TDLQQQQRQKSSRGGPYNNG-----YDDQNYDYILKNGEIFDKRYVILSDTPVGKGSFGQVTKAY 346

  Fly  1711 DMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLG 1775
            |......:|:|||||.:.:.:.|::||:.||.....|....:..|.:...|.:..|:|:|||:|.
 Worm   347 DTLNKEEVAIKIIKNKKTFFDQAQIEIHLLELTNAHDKDNKYNIVTLKGHFVHRAHLCLVFELLS 411

  Fly  1776 LSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLT--HTDLKPENILFVDSDYTSHYNHK 1838
            .:::|.|:..::....|:..|..|.||..::.||....|:  |.||||||:|.|::
 Worm   412 YNLYDLLKNTSFRGVSLNLARKFAQQLGKTLLFLSSPELSIIHCDLKPENVLLVNA--------- 467

  Fly  1839 INREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELY 1903
                    |.:.:|:|||||:..........:.:|.||:|||:|.:.:....|:||:||||.|::
 Worm   468 --------KRSQIRVIDFGSSCQTGHRIYQYIQSRFYRSPEVLLGIAYDTKIDMWSLGCILVEMH 524

  Fly  1904 LGITLFQTHDNREHLAMMERILGQIPYRM----ARNHTLYSKTKTKYFY---------------- 1948
            .|..||......:.:..:..:||..|..|    .:.|..:.||:...:|
 Worm   525 TGEPLFAGSSEVDQMMKIVEVLGMPPKEMLDIGPKTHKYFDKTEDGIYYCKKTRDGYRHTYKAPG 589

  Fly  1949 ----HGKLDWDEKSSAGRYVRD--HCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEAL 2007
                |..|........||.:.:  |          ..||:.:...|||:||:::|..||:....:
 Worm   590 ARKLHEILGVTSGGPGGRRLGEPGH----------SVEDYSKFKDLIKRMLQFDPKQRISPYYVV 644

  Fly  2008 HHPFF----DRLPPHHRVGEVSN---------KQPLSSGSSSRE 2038
            .|||.    :|:|....|.. ||         :||.|..|...|
 Worm   645 RHPFLKQKEERVPSQPPVSH-SNLQQQQQLYIQQPSSQMSQVME 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	102/362 (28%)
		S_TKc	1692..2012	CDD:214567	98/349 (28%)
mbk-1	NP_510460.2	PKc_DYRK1	312..651	CDD:271128	103/365 (28%)
		S_TKc	326..649	CDD:214567	98/349 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810