DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and Hipk3

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_034564.2	Gene:	Hipk3 / 15259	MGIID:	1314882	Length:	1192	Species:	Mus musculus

Alignment Length:	618	Identity:	150/618 - (24%)
Similarity:	267/618 - (43%)	Gaps:	129/618 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1483 THSASFSSAQR----PTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPE 1543
            |.|::|.|.::    |:...|           |::.:||          :.:..||:.|.....:
Mouse    15 TQSSAFCSVKKLKVEPSGCVF-----------QERTYPQ----------IHVNGRNFGNSHPSTK 58

  Fly  1544 RKPLQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPA 1608
            ....||..|:..|:.:..                 :..||      |.:..|....|::. |:.|
Mouse    59 GSAFQTKIPFTKPRGHSF-----------------SLQAG------AIVVKDTAGATKVL-AAQA 99

  Fly  1609 SSSSNKQPQQPQQQQQ------QQQSQLQQSNSVIFNHSGQQH-------QPHQQQQNEMSKSAL 1660
            ..:..:.|:....:.:      .|:..|::.:..:.||||...       .|...|.|..:...:
Mouse   100 QQAGVEAPRAVVWRNRLHFLEGPQRCGLKRKSEELENHSGAMQIVDELSILPAMLQTNMGNPVTV 164

  Fly  1661 GLHFIETAKPVIQDDADGHLIYHTGDIL---HHRYKIMATLGEGTFGRVVKVKDMERDYCMALKI 1722
            ......:.:.....:.|..|:.|  ::|   .:.|:::..||.||||:|||......:..:|:||
Mouse   165 VTATTGSKQNCTSGEGDYQLVQH--EVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKI 227

  Fly  1723 IKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNY 1787
            :||...|....::|::.|.:::.::.. ::..|:..:.|.:..|.|:|||||..:::|||::|.:
Mouse   228 LKNHPSYARQGQIEVSILARLSTENAD-EYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKF 291

  Fly  1788 EPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVR 1852
            .|.||..:|.:..|:..::|.|....|.|.|||||||:.||.          .|:..|||
Mouse   292 SPLPLKVIRPVLQQVATALKKLKSLGLIHADLKPENIMLVDP----------VRQPYRVK----- 341

  Fly  1853 LIDFGSATFDHEHH------STIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQ- 1910
            :||||||:     |      ||.:.:|:|||||:||.|.:.:..|:||:||::.||:||..|:.
Mouse   342 VIDFGSAS-----HVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPG 401

  Fly  1911 --THDNREHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLDW------DEKSSAGRYVRDH 1967
              .:|...:::..:.:.|:....:....|.:...:|...:.|   |      :.::..|...::.
Mouse   402 ALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCRETDMSHSG---WRLKTLEEHEAETGMKSKEA 463

  Fly  1968 CKPLFLC-----------------QLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDR- 2014
            .|.:|..                 .|::..|..|..:|:||||..:...|||..|.|:|||.:.
Mouse   464 RKYIFNSLDDIVHVNTVMDLEGGDLLAEKADRREFVNLLKKMLLIDADLRITPIETLNHPFVNMK 528

  Fly  2015 ----LPPHHRVGEVSNKQPL-SSGSSSRERSHS 2042
                .|..:.|....:...: .|.||....:||
Mouse   529 HLLDFPHSNHVKSCFHIMDICKSPSSCETNNHS 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	108/367 (29%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	105/351 (30%)
Hipk3	NP_034564.2	PKc_like	196..525	CDD:304357	105/352 (30%)
		S_TKc	197..525	CDD:214567	105/351 (30%)
		Interaction with AR. /evidence=ECO:0000250	767..921
		Interaction with FAS. /evidence=ECO:0000269\|PubMed:11034606	775..868
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	799..829
		Required for localization to nuclear speckles. /evidence=ECO:0000250	832..988
		SUMO interaction motifs (SIM), required for nuclear localization and kinase activity. /evidence=ECO:0000250	843..895
		Interaction with UBL1. /evidence=ECO:0000250	847..857
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	889..943
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..1023
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810