DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and Dyrk1a

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_001106860.1	Gene:	Dyrk1a / 13548	MGIID:	1330299	Length:	763	Species:	Mus musculus

Alignment Length:	617	Identity:	154/617 - (24%)
Similarity:	255/617 - (41%)	Gaps:	161/617 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1484 HSASFSSAQRPTALQ------FHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQP 1542
            |:...:||.:|::::      ||     ...||...|.|    |.|.           |:..:||
Mouse     2 HTGGETSACKPSSVRLAPSFSFH-----AAGLQMAAQMP----HSHQ-----------YSDRRQP 46

  Fly  1543 ERKPLQTFD-PYA----YPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTN--- 1599
            .....|... ||:    .|..||:.|.....|::.|.| |:                ||.|.
Mouse    47 SISDQQVSALPYSDQIQQPLTNQVMPDIVMLQRRMPQT-FR----------------DPATAPLR 94

  Fly  1600 -------------TQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQ 1651
                         .:::||              :::::.||.|...|:          |:..::.
Mouse    95 KLSVDLIKTYKHINEVYYA--------------KKKRRHQQGQGDDSS----------HKKERKV 135

  Fly  1652 QNEMSKSALGLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDY 1716
            .|:.                 .||.:...|...|:....||:|.:.:|:|:||:|||..|.....
Mouse   136 YNDG-----------------YDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQE 183

  Fly  1717 CMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDF 1781
            .:|:|||||.:.:...|::|:..||.:.:.|....:..|.:...|.:..|:|:|||||..:::|.
Mouse   184 WVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDL 248

  Fly  1782 LRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLT--HTDLKPENILFVDSDYTSHYNHKINREVR 1844
            ||..|:....|:..|..|.|:|.::.||....|:  |.||||||||..:.
Mouse   249 LRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNP--------------- 298

  Fly  1845 RVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLF 1909
              |.:.::::||||:....:.....:.:|.||:|||:|.:.:....|:||:||||.|::.|..||
Mouse   299 --KRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLF 361

  Fly  1910 QTHDNREHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLD--WD-EKSSAGRYVRDHCKPL 1971
            ...:..:.:..:..:||..|     .|.|....|.:.|:....|  |. :|:..|:  |:: ||.
Mouse   362 SGANEVDQMNKIVEVLGIPP-----AHILDQAPKARKFFEKLPDGTWSLKKTKDGK--REY-KPP 418

  Fly  1972 FLCQLSD--------------------SEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDRLP 2016
            ...:|.:                    ..|:.:...||.:||:|:|.:||....||.|.||.:..
Mouse   419 GTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFKKTA 483

  Fly  2017 PH--HRVGEVSN----KQPLSSGSSSRERSHS 2042
            ..  :....||.    :|..|||::|...|.|
Mouse   484 DEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSS 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	104/357 (29%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	101/344 (29%)
Dyrk1a	NP_001106860.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..61		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..136		5/30 (17%)
		Bipartite nuclear localization signal. /evidence=ECO:0000255	117..134		5/26 (19%)
		PKc_DYRK1	148..484	CDD:271128	106/360 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..442		5/36 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..540		9/31 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..679
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810