DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and Clk2

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_031738.2	Gene:	Clk2 / 12748	MGIID:	1098669	Length:	499	Species:	Mus musculus

Alignment Length:	557	Identity:	279/557 - (50%)
Similarity:	362/557 - (64%)	Gaps:	76/557 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1482 LTHSASFSSAQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKP 1546
            :.|...:.|::|.:...:|:.:|.::|.:::                   ||::.:...:..|:.
Mouse     1 MPHPRRYHSSERGSRGSYHEHYQSRKHKRRR-------------------SRSWSSSSDRTRRRR 46

  Fly  1547 LQTFDPYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSS 1611
            .:  |.|                    |.:.:::             ||.:::.:..|......|
Mouse    47 RE--DSY--------------------HVRSRSS-------------YDDHSSDRRLYDRRYCGS 76

  Fly  1612 SNKQPQQPQQQQQQQQSQLQQS------NSVIFNH--SGQQHQPHQQQQNEMSKSALGLHFIETA 1668
            ..:......:.:....:..:||      ||...:.  |.::|:..:::....|:|:  .|....|
Mouse    77 YRRNDYSRDRGEAYYDTDFRQSYEYHRENSSYRSQRSSRRKHRRRRRRSRTFSRSS--SHSSRRA 139

  Fly  1669 KPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYC-MALKIIKNVEKYREA 1732
            |.| :|||:||||||.||.|..||:|::|||||||||||:..|..|... :|||||||||||:||
Mouse   140 KSV-EDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGTQVALKIIKNVEKYKEA 203

  Fly  1733 AKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRH 1797
            |:||||.||||.:|||...:|||:|.|||||||||||.||:||||.||||::|||.|||:.||||
Mouse   204 ARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRH 268

  Fly  1798 MAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFD 1862
            ||:|||.:|||||||:||||||||||||||:|||...||.:..|:.|.||:|.||::||||||||
Mouse   269 MAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFD 333

  Fly  1863 HEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQ 1927
            ||||||||||||||||||||||||||||||||||||:||.|:|.||||||||||||||||||||.
Mouse   334 HEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGP 398

  Fly  1928 IPYRMARNHTLYSKT-KTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFSLIKK 1991
            :|.||.|      || |.||||.|:|||||.:|||||||::||||.....|::|||.:||.||:.
Mouse   399 VPSRMIR------KTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEDHHQLFDLIEN 457

  Fly  1992 MLEYEPSSRITLGEALHHPFFDRL---PPHHRVGEVS 2025
            ||||||:.|:||||||.||||..|   ||:.::.:.|
Mouse   458 MLEYEPAKRLTLGEALQHPFFACLRTEPPNTKLWDSS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	241/334 (72%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	232/321 (72%)
Clk2	NP_031738.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..65		14/117 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..142		9/41 (22%)
		PKc_CLK2	149..478	CDD:271117	241/334 (72%)
		S_TKc	162..478	CDD:214567	232/321 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849608
Domainoid	1	1.000	483	1.000	Domainoid score	I404
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H33303
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1597
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	1	1.000	-	-		otm42815
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	LDO	PTHR45646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R660
SonicParanoid	1	1.000	-	-		X440
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.680