DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and Clk1

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_001036099.1	Gene:	Clk1 / 12747	MGIID:	107403	Length:	483	Species:	Mus musculus

Alignment Length:	515	Identity:	230/515 - (44%)
Similarity:	315/515 - (61%)	Gaps:	64/515 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1508 HLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMPKQPERKPLQTFDPYAYPKPNQMQPVKYQQQQQH 1572
            |.::::.|...::.:...:.....:.:||...:....|        ||.....:.
Mouse    28 HKRKKRSHSSAREQKRCRYDHSKTTDSYYLESRSINEK--------AYHSRRYVD---------- 74

  Fly  1573 PHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNSVI 1637
               :::|...|...|...|   :|.:..|: ::|.:|..|.:...:.:.:.:
Mouse    75 ---EYRNDYMGYEPGHPYG---EPGSRYQM-HSSKSSGRSGRSSYKSKHRSR------------- 119

  Fly  1638 FNHSGQQHQPHQQQQNEMSKSALGLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGT 1702
             :|:.|.|...:..:.:.|:|             ::||.:||||..:||:|..||:|:.|||||.
Mouse   120 -HHTSQHHSHGKSHRRKRSRS-------------VEDDEEGHLICQSGDVLSARYEIVDTLGEGA 170

  Fly  1703 FGRVVKVKDME----RDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDY 1763
            ||:||:..|.:    |   :|:||:|||::|.|||:.||..||.:...|||....||:|::||::
Mouse   171 FGKVVECIDHKVGGRR---VAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEH 232

  Fly  1764 HGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVD 1828
            .||:|||||:||||.:||::||::.|:.:|.:|.||||:|.||.|||.|:||||||||||||||.
Mouse   233 RGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVK 297

  Fly  1829 SDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVW 1893
            ||||..||.|:.|:.|.:.|.|::::||||||:|.|||||:|||||||||||||.||||||||||
Mouse   298 SDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVW 362

  Fly  1894 SIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARNHTLYSKTKTKYFYHGKLDWDEKS 1958
            ||||||.|.|||.|:|.|||:||||||||||||.:|     .|.:....|.:||:|.:|||||.|
Mouse   363 SIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLP-----KHMIQKTRKRRYFHHDRLDWDEHS 422

  Fly  1959 SAGRYVRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFFDRLPPH 2018
            ||||||...||||....||...:|..||.||.|||||:|:.||||.|||.||||..|..|
Mouse   423 SAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKH 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	202/336 (60%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	195/323 (60%)
Clk1	NP_001036099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		2/20 (10%)
		Nuclear localization signal. /evidence=ECO:0000255	29..33		0/3 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..146		14/92 (15%)
		PKc_CLK1_4	147..476	CDD:271115	202/336 (60%)
		S_TKc	160..476	CDD:214567	195/323 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	1	1.000	-	-		otm42815
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	O	PTHR45646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R660
SonicParanoid	1	1.000	-	-		X440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.800