DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and CLK2

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	NP_001281267.1	Gene:	CLK2 / 1196	HGNCID:	2069	Length:	499	Species:	Homo sapiens

Alignment Length:	558	Identity:	277/558 - (49%)
Similarity:	361/558 - (64%)	Gaps:	91/558 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  1482 LTHSASFSSAQRPTALQFHQQHQQQQHLQQQQQ------HPQQQQHQHSSFGVGMMSRNYYNMPK 1540
            :.|...:.|::|.:...:.:.::.::|.:::.:      ...:::.:..|:.|  .||:.|: .:
Human     1 MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHV--RSRSSYD-DR 62

  Fly  1541 QPERKPLQTFD----------PYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYD 1595
            ..:|:   .:|          .|:..:.:......|:...::   |.:|:|
Human    63 SSDRR---VYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEY---QRENSS-------------- 107

  Fly  1596 PNTNTQLFYASPASSSSNKQPQQPQQQQQQQQSQLQQSNSVIFNHSGQQHQPHQQQQNEMSKSAL 1660
                    |.|              |:..:::.:.::..|..|:.|..||      .:..:||
Human   108 --------YRS--------------QRSSRRKHRRRRRRSRTFSRSSSQH------SSRRAKS-- 142

  Fly  1661 GLHFIETAKPVIQDDADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYC-MALKIIK 1724
                       ::|||:||||||.||.|..||:|::|||||||||||:..|..|... :||||||
Human   143 -----------VEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIK 196

  Fly  1725 NVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEP 1789
            |||||:|||:||||.||||.:|||...:|||:|.|||||||||||.||:||||.||||::|||.|
Human   197 NVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLP 261

  Fly  1790 YPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLI 1854
            ||:.||||||:|||.:|||||||:||||||||||||||:|||...||.:..|:.|.||:|.||::
Human   262 YPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVV 326

  Fly  1855 DFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLA 1919
            ||||||||||||||||||||||||||||||||||||||||||||:||.|:|.|||||||||||||
Human   327 DFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLA 391

  Fly  1920 MMERILGQIPYRMARNHTLYSKT-KTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHC 1983
            |||||||.||.||.|      || |.||||.|:|||||.:|||||||::||||.....|::|:|.
Human   392 MMERILGPIPSRMIR------KTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHH 450

  Fly  1984 ELFSLIKKMLEYEPSSRITLGEALHHPFFDRL---PPH 2018
            :||.||:.||||||:.|:||||||.||||.||   ||:
Human   451 QLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPN 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	241/334 (72%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	232/321 (72%)
CLK2	NP_001281267.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		9/68 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..143		13/99 (13%)
		PKc_CLK2	150..479	CDD:271117	241/334 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159239
Domainoid	1	1.000	483	1.000	Domainoid score	I406
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H33303
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1597
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	1	1.000	-	-		otm40742
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	LDO	PTHR45646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R660
SonicParanoid	1	1.000	-	-		X440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.680