DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Doa and Dyrk4

DIOPT Version :9

Sequence 1:	NP_001014681.2	Gene:	Doa / 43415	FlyBaseID:	FBgn0265998	Length:	2045	Species:	Drosophila melanogaster
Sequence 2:	XP_011239406.1	Gene:	Dyrk4 / 101320	MGIID:	1330292	Length:	685	Species:	Mus musculus

Alignment Length:	605	Identity:	148/605 - (24%)
Similarity:	254/605 - (41%)	Gaps:	123/605 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1426 QAPKSGLAMFLQKNTNKENKFGQPMQQQPPGMMPQMYGYQAPQQQSKIGYPRTGAPLTHSASFSS 1490
            :|.|..|..|......|:..|   ...:.|.:.|::|     ..:||        ||.|....||
Mouse    63 KARKRSLTTFPILKARKKQSF---TSVKGPTLPPEIY-----MVESK--------PLGHLQKPSS 111

  Fly  1491 AQRPTALQFHQQHQQQQHLQQQQQHPQQQQHQHSSFGVGMMSRNYYNMP----KQPERKPLQTFD 1551
            ..:...:     ::..|.:......|         |......||..|.|    |.|.:.|:|
Mouse   112 KNKKLRV-----NRCPQKIPSNTAFP---------FVDTKGKRNTVNFPQIGNKVPSKGPMQ--- 159

  Fly  1552 PYAYPKPNQMQPVKYQQQQQHPHTQFQNASAGGGGGGAAGLQYDPNTNTQLFYASPASSSSNKQP 1616
                          ||:.|.|.........       .:.:.::.||..|.....|.....:|.|
Mouse   160 --------------YQENQIHNQVLSSELK-------TSEIPFNINTKAQDTKPHPELQKKHKVP 203

  Fly  1617 QQPQQQQQQQQSQLQ-QSNSVIFNHS-----GQQHQPHQQQQNEMSKSALGLHFIETAKPVIQDD 1675
            ....:..:..::||. ...|.|..:|     |.:.:.......:.||::.             ||
Mouse   204 LTVAEALKFFKNQLSPYEQSEILGYSELWFLGLEAKKLNVVPEKFSKTSF-------------DD 255

  Fly  1676 ADGHLIYHTGDILHHRYKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINAL 1740
            ..|..:....|.:.:||:::..:|:|:||:|.|..|.:.:..:|||||:|.:::...|.:|:..|
Mouse   256 EHGSYMKVLHDHIAYRYEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKIL 320

  Fly  1741 EKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYPLDQVRHMAYQLCYS 1805
            |.:.:||...:|..|.|.|:|.:..|:||.||:||:::::.::.|::..:.|..||...:.:...
Mouse   321 EALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKC 385

  Fly  1806 VKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIV 1870
            :..|:..::.|.|||||||:.......:                 |::|||||:.::|:...|.:
Mouse   386 LHMLYVEKIIHCDLKPENIVLYQRGQVT-----------------VKVIDFGSSCYEHQKVYTYI 433

  Fly  1871 STRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARN 1935
            .:|.||:|||||...::...|:||:|||:.|||.|..||...:..|.||.:..:||..|     .
Mouse   434 QSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLGLPP-----A 493

  Fly  1936 HTLYSKTKTKYFYHGK-LDWDEKSSAG--RYVRDHCKPLFLCQLSDSED--------HCELFSLI 1989
            |...:.::.:.|:..| |..:..::.|  ||             .||:|        .......:
Mouse   494 HFTQTASRRQVFFDSKGLPKNINNNRGGKRY-------------PDSKDLTMVVKTYDSSFLDFL 545

  Fly  1990 KKMLEYEPSSRITLGEALHH 2009
            ::.|.:|||.|:|..:||.|
Mouse   546 RRCLVWEPSLRMTPEQALKH 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Doa	NP_001014681.2	PKc_CLK	1679..2012	CDD:271036	100/342 (29%)
Doa	NP_001014681.2	S_TKc	1692..2012	CDD:214567	98/329 (30%)
Dyrk4	XP_011239406.1	PKc_DYRK4	228..568	CDD:271127	107/386 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810