DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl21 and ECE2

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001093590.1	Gene:	ECE2 / 9718	HGNCID:	13275	Length:	811	Species:	Homo sapiens

Alignment Length:	749	Identity:	211/749 - (28%)
Similarity:	342/749 - (45%)	Gaps:	113/749 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ICIAGHVLSAMVAAAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYKR 79
            :.:|..:|..:||.......|....|...:..:|.|  .:|...:|:...||.|||.||||.:.|
Human   114 LLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVA--GKILESLDRGVSPCEDFYQFSCGGWIR 176

  Fly    80 INSALSMQVVTTG-----VFETLTKGLNRKILKML--NTPHDSHDTPEDIKVKHFYESCLQIKEL 137
            .|.      :..|     .|.:|. ..|:.|||.|  ||..:|....|. |.:.||.||||::.:
Human   177 RNP------LPDGRSRWNTFNSLW-DQNQAILKHLLENTTFNSSSEAEQ-KTQRFYLSCLQVERI 233

  Fly   138 NSTYSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTARMAYRYGITPIFGIEVNKDLASN 198
            ....::.|:.||.:.|    |.|      |.:|:|  :.....:|..|..||.|.:.::.|..|:
Human   234 EELGAQPLRDLIEKIGGWNITGP------WDQDNF--MEVLKAVAGTYRATPFFTVYISADSKSS 290

  Fly   199 TRNRIYLGQQDFPLEARSMYVDDATAVYRQKYRNNIQRILQRYLGVKMDL----------AKKTA 253
            ..|.|.:.|....|.:|..|::          |...:::|..||....:|          .::..
Human   291 NSNVIQVDQSGLFLPSRDYYLN----------RTANEKVLTAYLDYMEELGMLLGGRPTSTREQM 345

  Fly   254 KELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLD-IDRLLFVSMGERISDQ--IY 315
            :::::.|:.||...|.:.:..|..::...:::.|:| ..:|::| ::.|.|:.....:||.  :.
Human   346 QQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ-ALAPSMDWLEFLSFLLSPLELSDSEPVV 409

  Fly   316 EYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPSDSPEKQMKA----------------- 363
            .|...|.|.:.|:|.||....:.||    |||..|:..:.|.:::.::
Human   410 VYGMDYLQQVSELINRTEPSILNNY----LIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCV 470

  Fly   364 -----CVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRN 423
                 |:..|.......|.::|.:...:.:|....:.|..::::.|.|.|..   |.|::..||.
Human   471 PRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQ---LVWMDEKTRQ 532

  Fly   424 LAMAKLQAMTLEVNNYADDNFTEEFAELN-------LQSDDYVENVRYTSLLGAKQMREMLHKPA 481
            .|..|..|: .::..:.|  |..|..||:       :..|.:.:|:.......||.|.:.|.||
Human   533 AAKEKADAI-YDMIGFPD--FILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKP- 593

  Fly   482 KPFEAGSQLSYTPANI-----LIENTIKVPVALLQ-PFYIWSDVYPNAIMFGTLASLIGHELIHG 540
               .:..|.|.||..:     ..:|.|..|..:|| |||..:  :|.|:.||.:..::||||.|.
Human   594 ---PSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARN--HPKALNFGGIGVVMGHELTHA 653

  Fly   541 FDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENIADNGGMRL 605
            |||.||::|::||.:.||..:|.:.|.....|..:||.:|..:|.:|.......||||||||::.
Human   654 FDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKA 718

  Fly   606 AYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHM 670
            ||.||:.|...     :|.:    :.||.:..|..||||:.|||.||:...|......:.||.|.
Human   719 AYNAYKAWLRK-----HGEE----QQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHS 774

  Fly   671 PGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKC 704
            |.||||:|:|||..:|.:.|.||.||.|||.:.|
Human   775 PARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	202/707 (29%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	200/699 (29%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..64
ECE2	NP_001093590.1	M13	160..809	CDD:189000	201/701 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150974
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950