Protein Alignment Nepl21 and ECE2

DIOPT Version :10

• Sequence 1: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_001093590.1
• Gene: ECE2 / 9718
• HGNCID: 13275
• Length: 811
• Species: Homo sapiens
• Alignment Length: 749
• Identity: 211/749 - (28%)
• Similarity: 342/749 - (45%)
• Gaps: 113/749 - (15%)

  Fly    15 ICIAGHVLSAMVAAAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYKR 79
            :.:|..:|..:||.......|....|...:..:|.|  .:|...:|:...||.|||.||||.:.|
Human   114 LLLAALLLGCLVALGVQYHRDPSHSTCLTEACIRVA--GKILESLDRGVSPCEDFYQFSCGGWIR 176

  Fly    80 INSALSMQVVTTG-----VFETLTKGLNRKILKML--NTPHDSHDTPEDIKVKHFYESCLQIKEL 137
            .|.      :..|     .|.:|. ..|:.|||.|  ||..:|....|. |.:.||.||||::.:
Human   177 RNP------LPDGRSRWNTFNSLW-DQNQAILKHLLENTTFNSSSEAEQ-KTQRFYLSCLQVERI 233

  Fly   138 NSTYSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTARMAYRYGITPIFGIEVNKDLASN 198
            ....::.|:.||.:.|    |.|      |.:|:|  :.....:|..|..||.|.:.::.|..|:
Human   234 EELGAQPLRDLIEKIGGWNITGP------WDQDNF--MEVLKAVAGTYRATPFFTVYISADSKSS 290

  Fly   199 TRNRIYLGQQDFPLEARSMYVDDATAVYRQKYRNNIQRILQRYLGVKMDL----------AKKTA 253
            ..|.|.:.|....|.:|..|::          |...:::|..||....:|          .::..
Human   291 NSNVIQVDQSGLFLPSRDYYLN----------RTANEKVLTAYLDYMEELGMLLGGRPTSTREQM 345

  Fly   254 KELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLD-IDRLLFVSMGERISDQ--IY 315
            :::::.|:.||...|.:.:..|..::...:::.|:| ..:|::| ::.|.|:.....:||.  :.
Human   346 QQVLELEIQLANITVPQDQRRDEEKIYHKMSISELQ-ALAPSMDWLEFLSFLLSPLELSDSEPVV 409

  Fly   316 EYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPSDSPEKQMKA----------------- 363
            .|...|.|.:.|:|.||....:.||    |||..|:..:.|.:::.::
Human   410 VYGMDYLQQVSELINRTEPSILNNY----LIWNLVQKTTSSLDRRFESAQEKLLETLYGTKKSCV 470

  Fly   364 -----CVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRN 423
                 |:..|.......|.::|.:...:.:|....:.|..::::.|.|.|..   |.|::..||.
Human   471 PRWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRTAFEEALGQ---LVWMDEKTRQ 532

  Fly   424 LAMAKLQAMTLEVNNYADDNFTEEFAELN-------LQSDDYVENVRYTSLLGAKQMREMLHKPA 481
            .|..|..|: .::..:.|  |..|..||:       :..|.:.:|:.......||.|.:.|.||
Human   533 AAKEKADAI-YDMIGFPD--FILEPKELDDVYDGYEISEDSFFQNMLNLYNFSAKVMADQLRKP- 593

  Fly   482 KPFEAGSQLSYTPANI-----LIENTIKVPVALLQ-PFYIWSDVYPNAIMFGTLASLIGHELIHG 540
               .:..|.|.||..:     ..:|.|..|..:|| |||..:  :|.|:.||.:..::||||.|.
Human   594 ---PSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYARN--HPKALNFGGIGVVMGHELTHA 653

  Fly   541 FDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENIADNGGMRL 605
            |||.||::|::||.:.||..:|.:.|.....|..:||.:|..:|.:|.......||||||||::.
Human   654 FDDQGREYDKEGNLRPWWQNESLAAFRNHTACMEEQYNQYQVNGERLNGRQTLGENIADNGGLKA 718

  Fly   606 AYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHM 670
            ||.||:.|...     :|.:    :.||.:..|..||||:.|||.||:...|......:.||.|.
Human   719 AYNAYKAWLRK-----HGEE----QQLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHS 774

  Fly   671 PGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKC 704
            |.||||:|:|||..:|.:.|.||.||.|||.:.|
Human   775 PARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	M13	63..704	CDD:341056	200/699 (29%)
ECE2	NP_001093590.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..64
		M13	160..809	CDD:341056	201/701 (29%)