DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl21 and ECEL1

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_004817.2	Gene:	ECEL1 / 9427	HGNCID:	3147	Length:	775	Species:	Homo sapiens

Alignment Length:	765	Identity:	215/765 - (28%)
Similarity:	353/765 - (46%)	Gaps:	142/765 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLSAMVA------------AAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFS 73
            :|:||:|            |.|       :..|..|...|.|:.  :.:.:|...|||.|||:|:
Human    75 ILAAMLALKYLGPVAAGGGACP-------EGCPERKAFARAARF--LAANLDASIDPCQDFYSFA 130

  Fly    74 CGNYKRINSALSMQVVTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIKVKHFYESCLQIKELN 138
            ||.:.| ..|:....:|.|....:.:....::.::|..|..........||:.|:.|||.::|:
Human   131 CGGWLR-RHAIPDDKLTYGTIAAIGEQNEERLRRLLARPGGGPGGAAQRKVRAFFRSCLDMREI- 193

  Fly   139 STYSEKLKRLIAEFGTMPLLEGSSWQEDDFDW----------------LNTTARMAYR----YGI 183
                |:|       |..|:||..   ||...|                ||   |:.|:    |..
Human   194 ----ERL-------GPRPMLEVI---EDCGGWDLGGAEERPGVAARWDLN---RLLYKAQGVYSA 241

  Fly   184 TPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYV--DDATAVYRQKYRNNIQRILQRYLGVKM 246
            ..:|.:.|:.|..:::|..|.:.|....|..|::|:  |:.:......||..::|:|. .||.
Human   242 AALFSLTVSLDDRNSSRYVIRIDQDGLTLPERTLYLAQDEDSEKILAAYRVFMERVLS-LLGA-- 303

  Fly   247 DLAKKTAKELIDFEVDLAQGLVDESEGL--DVGELTQLLTVDEIQRRYSPTLDIDRLLFVSMGER 309
            |..::.|:|::..|..||...|.|.:.|  ||..:...:|:.::| :.:|.|....||
Human   304 DAVEQKAQEILQVEQQLANITVSEHDDLRRDVSSMYNKVTLGQLQ-KITPHLRWKWLL------- 360

  Fly   310 ISDQIYEYN-----------NRYQQNLVEVIKRTPKRTVANYIFFRLI---WEFVETP------- 353
              |||::.:           ..|.|.:.::|:.||.|.:.||:.:|::   .|.:..|
Human   361 --DQIFQEDFSEEEEVVLLATDYMQQVSQLIRSTPHRVLHNYLVWRVVVVLSEHLSPPFREALHE 423

  Fly   354 -------SDSPEKQMKACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSS 411
                   ||.|::..:.|:....::|...|..:|...:.:..|..::..:...:|....:.|..
Human   424 LAQEMEGSDKPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEE- 487

  Fly   412 PALNWIERPTRNLAMAKLQAMTLEVNNYAD-----DNFTEEFAELNLQSDDYVEN----VRYTSL 467
              |:|::..||..|.||||.|.:.| .|.|     |...:|: |..:....|.:|    :|::..
Human   488 --LDWMDAETRAAARAKLQYMMVMV-GYPDFLLKPDAVDKEY-EFEVHEKTYFKNILNSIRFSIQ 548

  Fly   468 LGAKQMREMLHK-----PAKPFEAGSQLSYTPANILIENTIKVPVALLQPFYIWSDVYPNAIMFG 527
            |..|::|:.:.|     |.:...|    .|.|.    :|.:..|..:||| .::...:|.::.:|
Human   549 LSVKKIRQEVDKSTWLLPPQALNA----YYLPN----KNQMVFPAGILQP-TLYDPDFPQSLNYG 604

  Fly   528 TLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTA 592
            .:.::|||||.||:||.|.::|..||...||.|.|.|.||::.:|..:.|..:.....::.....
Human   605 GIGTIIGHELTHGYDDWGGQYDRSGNLLHWWTEASYSRFLRKAECIVRLYDNFTVYNQRVNGKHT 669

  Fly   593 QSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHP 657
            ..|||||.||::|||.||:||...     :|.:    ..||.|:||..|||||:|||:||.....
Human   670 LGENIADMGGLKLAYHAYQKWVRE-----HGPE----HPLPRLKYTHDQLFFIAFAQNWCIKRRS 725

  Fly   658 SVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKCILY 707
            ....|||.||:|.|..:||:||:|.||||.:.|:||..|.|||:.||.::
Human   726 QSIYLQVLTDKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPAHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	205/715 (29%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	202/706 (29%)
ECEL1	NP_004817.2	M13	120..773	CDD:341056	203/707 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950