Protein Alignment Nepl21 and MMEL1

DIOPT Version :10

• Sequence 1: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_258428.2
• Gene: MMEL1 / 79258
• HGNCID: 14668
• Length: 779
• Species: Homo sapiens
• Alignment Length: 718
• Identity: 202/718 - (28%)
• Similarity: 326/718 - (45%)
• Gaps: 106/718 - (14%)

  Fly    53 AEIESFMDQKADPCNDFYAFSCGNYKR------INSALSMQVVTTGVFETLTKGLNRKILKMLNT 111
            |.|...||...:||:|||.|:||.:.|      .||..|       :|:.|...| ..|||.:..
Human    99 ARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYS-------IFDVLRDEL-EVILKAVLE 155

  Fly   112 PHDSHDTPEDIKVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQED---DFDWLNT 173
            ...:.|.|...|.:..|.||:....:....|:.|..::...|..|:.. ..|.|.   :::....
Human   156 NSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAM-DRWNETVGLEWELERQ 219

  Fly   174 TARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDDAT-----AVYRQKYRNN 233
            .|.|..::....:..:.:..|..:::|:.||:.|....:.:|..|.:..:     ..|.| :..:
Human   220 LALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQ-FMVS 283

  Fly   234 IQRILQRYLGVKMD--LAKKTAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQ-----RR 291
            :..:|:....:..|  |.::...::::.|..||:..|.:.|..||..|...:.::|:|     :.
Human   284 VATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKG 348

  Fly   292 YSPTLDIDRLL-FVSMGERISDQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPSD 355
            ::.||.|..:| .|.:.....:::..|...|.|||..:|.....||:.||:.:||:.:.:.:.|.
Human   349 FNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQ 413

  Fly   356 S-----------------PEKQMKACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQL--- 400
            .                 .|.:.:.||.    |...|::|.....|..|....:..:|.|:|
Human   414 RFKDTRVNYRKALFGTMVEEVRWRECVG----YVNSNMENAVGSLYVREAFPGDSKSMVRELIDK 474

  Fly   401 -KSTFNETLRSSPALNWIERPTRNLAMAKLQAMTL------------EVNNYADDNFTEEFAELN 452
             ::.|.|||   ..|.|::..::..|..|  ||::            |:|...|    ||::.||
Human   475 VRTVFVETL---DELGWMDEESKKKAQEK--AMSIREQIGHPDYILEEMNRRLD----EEYSNLN 530

  Fly   453 LQSDDYVENVRYTSLLGAKQMREMLHKPAKP--FEAGSQL---SYTPANILIENTIKVPVALLQP 512
            ...|.|.||......:||::....|.:...|  :..|:.:   .|:|.    .|.|..|..:|||
Human   531 FSEDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPN----RNQIVFPAGILQP 591

  Fly   513 FYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQY 577
            .: :|...|.|:.||.:..:||||:.|||||:||.||:.||..|||...|:.:|.::.:|...||
Human   592 PF-FSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQY 655

  Fly   578 GRYVYDGIQLKES------TAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLR 636
            |.|.:|   |.:.      ....||||||||:|.||.||.||      :..|.:|   :.||.|.
Human   656 GNYSWD---LADEQNVNGFNTLGENIADNGGVRQAYKAYLKW------MAEGGKD---QQLPGLD 708

  Fly   637 YTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPS 701
            .|.:|||||::||.||....|......:.||.|.|.::||:|||.|...|:..|:|..|:.|:|.
Human   709 LTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPK 773

  Fly   702 EKC 704
            |:|
Human   774 ERC 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	M13	63..704	CDD:341056	197/706 (28%)
MMEL1	NP_258428.2	M13	111..777	CDD:341056	198/706 (28%)