DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl21 and Ecel1

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_068544.2	Gene:	Ecel1 / 60417	RGDID:	61806	Length:	775	Species:	Rattus norvegicus

Alignment Length:	756	Identity:	211/756 - (27%)
Similarity:	355/756 - (46%)	Gaps:	124/756 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VLSAMVA-------AAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYK 78
            :|:||:|       ||.|... ..:..|..|...|.|:.  :.:.:|...|||.|||:|:||.:.
  Rat    75 ILAAMLALKYLGPGAAGTGGA-CPEGCPERKAFARAARF--LSANLDASIDPCQDFYSFACGGWL 136

  Fly    79 RINSALSMQVVTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIKVKHFYESCLQIKELNSTYSE 143
            | ..|:....:|.|....:.:....::.::|..|..........||:.|:.|||.::|:     |
  Rat   137 R-RHAIPDDKLTYGTIAAIGEQNEERLRRLLARPTGGPGGAAQRKVRAFFRSCLDMREI-----E 195

  Fly   144 KLKRLIAEFGTMPLLE-----------GSSWQEDDFDW-LNTTARMAYR----YGITPIFGIEVN 192
            :|       |..|:||           |::.:.....| ||   |:.|:    |....:|.:.|:
  Rat   196 RL-------GPRPMLEVIEDCGGWDLGGAADRPGAARWDLN---RLLYKAQGVYSAAALFSLTVS 250

  Fly   193 KDLASNTRNRIYLGQQDFPLEARSMYV--DDATAVYRQKYRNNIQRILQRYLGVKMDLAKKTAKE 255
            .|..:::|..|.:.|....|..|::|:  |:.:......|:..::|:| |.||.  |..::.|:|
  Rat   251 LDDRNSSRYVIRIDQDGLTLPERTLYLAQDEESEKVLAAYKVFMERLL-RLLGA--DAVEQKAQE 312

  Fly   256 LIDFEVDLAQGLVDESEGL--DVGELTQLLTVDEIQRRYSPTLDIDRLLFVSMGERISDQIYEYN 318
            ::..|..||...|.|.:.|  ||..:...:|:.::| :.:|.|....||         |||::.:
  Rat   313 ILQLEQRLANISVSEYDDLRRDVSSVYNKVTLGQLQ-KITPHLQWKWLL---------DQIFQED 367

  Fly   319 -----------NRYQQNLVEVIKRTPKRTVANYIFFRLI---WEFVETP--------------SD 355
                       ..|.|.:.::|:.||:|.:.||:.:|::   .|.:..|              :|
  Rat   368 FSEEEEVVLLATDYMQQVSQLIRSTPRRILHNYLVWRVVVVLSEHLSPPFREALHELAKEMEGND 432

  Fly   356 SPEKQMKACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERP 420
            .|::..:.|:....::|...|..:|...:.:..|..::..:...:|....:.|..   |:|::..
  Rat   433 KPQELARVCLGQANRHFGMALGALFVHEHFSAASKAKVQQLVEDIKYILGQRLEE---LDWMDAQ 494

  Fly   421 TRNLAMAKLQAMTLEVNNYAD-----DNFTEEFAELNLQSDDYVEN----VRYTSLLGAKQMREM 476
            |:..|.||||.|.:.| .|.|     :...:|: |..:....|.:|    :|::..|..|::|:.
  Rat   495 TKAAARAKLQYMMVMV-GYPDFLLKPEAVDKEY-EFEVHEKTYFKNILNSIRFSIQLSVKKIRQE 557

  Fly   477 LHK-----PAKPFEAGSQLSYTPANILIENTIKVPVALLQPFYIWSDVYPNAIMFGTLASLIGHE 536
            :.|     |.:...|    .|.|.    :|.:..|..:||| .::...:|.::.:|.:.::||||
  Rat   558 VDKSTWLLPPQALNA----YYLPN----KNQMVFPAGILQP-TLYDPDFPQSLNYGGIGTIIGHE 613

  Fly   537 LIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENIADNG 601
            |.||:||.|.::|..||...||.|.|.|.||.:.:|..:.|..:.....::.......|||||.|
  Rat   614 LTHGYDDWGGQYDRSGNLLHWWTEASYSRFLHKAECIVRLYDNFTVYNQRVNGKHTLGENIADMG 678

  Fly   602 GMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVST 666
            |::|||.||:||...     :|.:    ..|..|:||..|||||:|||:||.........|||.|
  Rat   679 GLKLAYYAYQKWVRE-----HGPE----HPLHRLKYTHNQLFFIAFAQNWCIKRRSQSIYLQVLT 734

  Fly   667 DQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKCILY 707
            |:|.|..:||:||:|.||||.:.|:||..|.|||..||.::
  Rat   735 DKHAPEHYRVLGSVSQFEEFGRAFHCPKDSPMNPVHKCSVW 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	200/711 (28%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	197/702 (28%)
Ecel1	NP_068544.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..51
Ecel1	NP_068544.2	M13	121..773	CDD:341056	198/703 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344508
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950