DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and PHEX

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_000435.3	Gene:	PHEX / 5251	HGNCID:	8918	Length:	749	Species:	Homo sapiens

Alignment Length:	772	Identity:	197/772 - (25%)
Similarity:	338/772 - (43%)	Gaps:	100/772 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GIKAKHNAKQLLCICIAGHVLSA----MVAAAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQK 62
            |.||....:..|.:.:.|.::..    :|:....|.: .||:.....|.:..|  |.|.|.::..
Human    12 GKKANRGTRIALVVFVGGTLVLGTILFLVSQGLLSLQ-AKQEYCLKPECIEAA--AAILSKVNLS 73

  Fly    63 ADPCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKGLNRKILKML-NTPHDSHDTPEDIKVKH 126
            .|||::|:.|:|..:.. |:.:...:.:.||:..|...::.|:.::| .:.....||....|.|.
Human    74 VDPCDNFFRFACDGWIS-NNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSISRRRDTEAIQKAKI 137

  Fly   127 FYESCLQIKELNSTYSEKLKRLI--AEFGTMPLLEGS-----SWQEDDFDWLNTTARMAYRYGIT 184
            .|.||:..|.:....::.|..::  :.| ..|:||.:     .|.|..|..|.|.|....:|..:
Human   138 LYSSCMNEKAIEKADAKPLLHILRHSPF-RWPVLESNIGPEGVWSERKFSLLQTLATFRGQYSNS 201

  Fly   185 PIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDDATAVYRQKYRNNIQRIL---QRYLGVKM 246
            ....:.|:.|..::..:.:.|.|....|..|..|:|::|..  :.||:.:.:.:   ...||...
Human   202 VFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEA--KSYRDALYKFMVDTAVLLGANS 264

  Fly   247 DLAKKTAKELIDFEVDLAQGLVDE----SEG----LDVGELTQLLTVDEIQRRYSPTLD------ 297
            ..|:...|.::..|:.:|:.::..    ||.    :::.||:.::          |..|
Human   265 SRAEHDMKSVLRLEIKIAEIMIPHENRTSEAMYNKMNISELSAMI----------PQFDWLGYIK 319

  Fly   298 --IDRLLF-----VSMGERISDQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPSD 355
              ||..|:     :|..|.:..::    .:|.::|..::....|:|:|||:.:|:::..:  |:.
Human   320 KVIDTRLYPHLKDISPSENVVVRV----PQYFKDLFRILGSERKKTIANYLVWRMVYSRI--PNL 378

  Fly   356 SPEKQMK-------------------ACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLK 401
            |...|.:                   .||:..:......:..||...|..|.....::.:...::
Human   379 SRRFQYRWLEFSRVIQGTTTLLPQWDKCVNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVR 443

  Fly   402 STFNETLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYA-----DDNFTEEFAELNLQSDDYVEN 461
            ..|.:.|....  .|::..|:..|..|.:|:..:| .|.     |.:..|:...:.....||..|
Human   444 WAFIDMLEKEN--EWMDAGTKRKAKEKARAVLAKV-GYPEFIMNDTHVNEDLKAIKFSEADYFGN 505

  Fly   462 VRYTSLLGAKQMREMLHKPAKPFEAGSQLSYTPANILIE---NTIKVPVALLQPFYIWSDVYPNA 523
            |..|....|:.....|.|.....|..:  :.|..|....   |.|:.|...||..:.|...||.:
Human   506 VLQTRKYLAQSDFFWLRKAVPKTEWFT--NPTTVNAFYSASTNQIRFPAGELQKPFFWGTEYPRS 568

  Fly   524 IMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD--GIQ 586
            :.:|.:..::|||..||||::|||:|:.||...||..:|...|.::..|...||..|.:.  |:.
Human   569 LSYGAIGVIVGHEFTHGFDNNGRKYDKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLN 633

  Fly   587 LKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSW 651
            :|......||||||||:|.|:.|||||..::      .|.:.:..||.:.:|..||||:|:|...
Human   634 VKGKRTLGENIADNGGLREAFRAYRKWINDR------RQGLEEPLLPGITFTNNQLFFLSYAHVR 692

  Fly   652 CNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPS-EKCILY 707
            ||...|.....||....|.|.:|||.|::||||||.|.||||..|.||.. :.|.|:
Human   693 CNSYRPEAAREQVQIGAHSPPQFRVNGAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	183/711 (26%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	181/702 (26%)
PHEX	NP_000435.3	M13	74..747	CDD:189000	181/703 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.020