DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and Nep5

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_733186.2	Gene:	Nep5 / 43255	FlyBaseID:	FBgn0039478	Length:	882	Species:	Drosophila melanogaster

Alignment Length:	797	Identity:	212/797 - (26%)
Similarity:	346/797 - (43%)	Gaps:	180/797 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYK---------------RINSALSMQVVTTGV 93
            ||.||.|  |.:...||::.|||.|||.|:||.:.               |...|..|:||...:
  Fly   133 KECLRTA--ASLIYAMDEQTDPCEDFYQFTCGRWANEHPRPDSVTSNDWFRERQAHIMRVVREFL 195

  Fly    94 FETLTKGLNRKILKMLNTPHDSHDTPEDI-KVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPL 157
            ...:||                 ..||.: |.|..|.:|:..|.|:....|.|...:..|| :|:
  Fly   196 RSNITK-----------------SEPEAVGKAKTMYRACMDTKLLDKRDLEPLINYLLRFG-LPV 242

  Fly   158 L---------EGSSWQED----DFDWLNTTARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQD 209
            |         .||.:..:    .::||.:...:.....:..|.|.:|..|..:.|.|||.||..:
  Fly   243 LPSALNLTLGSGSKYATEAANVKYNWLQSIVSIKQHLTMDLIIGFDVFPDPFNRTINRIALGTPE 307

  Fly   210 ----FP------------LEARSMYV------DDA--------------TAVYRQKYRNNIQRIL 238
                ||            :..:::::      ||:              |:.....|.:.:::::
  Fly   308 TDSAFPFNNDDSHKMLRKIHRKTIFMQNSDDEDDSEDDRESEEEEAAKQTSTGMTAYLHYVRKVI 372

  Fly   239 QRYL-----GVKMDLAKKTAKELIDFEVDLAQGL---VDESEGL---------DVGELTQLLTVD 286
            ::||     .|..:.|.....||:...|.:|:.:   .:|:|.:         |:..:|.....:
  Fly   373 EKYLLYVDPNVNQEEATLGITELVKQGVRVARKVHEFKEEAENMTKPSKNPADDIVYITLQDLQN 437

  Fly   287 EIQRRYSP-TLDI--DRLLFVSMGERISDQIYEYNN----------RYQQNLVEVIKRTPKRTVA 338
            :..:..:| ||.|  ..:..:..|.|.:..|....|          .|.||:||.:..||...:.
  Fly   438 QTDKNIAPKTLPIWVRYMELILKGTRHAGNIQMTQNLTIITSQADITYLQNIVEYLDDTPASHIE 502

  Fly   339 NYIFFRLIWEFVETPSDS----PEKQMKACVDL-----TKKYFAKNLDNMFYRR---------YN 385
            :|:|...|.|.|...|.|    ..:.|:..:..     ...|.|..::::....         :.
  Fly   503 SYLFLSTIEELVLHTSSSMRLLHSEYMRVAIGTEGSTPRSLYCANGVNSLLGMAVSYVLADADFT 567

  Fly   386 NEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEV------NNYADDNF 444
            .||..: ::.|...::.:|:..::|:   :|::..|:...:.|...|...:      .|.:..|.
  Fly   568 KEKLPK-VERMLSDIRRSFDRLVKST---SWMDAATKRKTIQKSAEMKSFIGFPPWLRNASVLNA 628

  Fly   445 TEEFAELNLQSDDYVEN----VRYTSLLGAKQMREMLHKPAKPFEAGSQLSYTPANI-----LIE 500
            ..|.||:|  :..::||    |.:       ||.:.|::..||...|...|  |:|:     ...
  Fly   629 YYEGAEVN--ASTHLENLMDFVHW-------QMMDKLNEMDKPEPIGWATS--PSNVNAFHTFQS 682

  Fly   501 NTIKVPVALLQ-PFYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSS 564
            |.|.||:|:|| |||   |:...|:.:|::.:::||||.||||||||:||..||..:||..::..
  Fly   683 NAITVPIAILQYPFY---DLGLEALNYGSIGTILGHELTHGFDDSGRRFDRAGNMVEWWSNRTID 744

  Fly   565 NFLKRRDCFTKQYGRYVYDGIQ--LKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDM 627
            .::.|.:||.:||.||....|.  :.......||||||||||.|:.|||      |.:....::.
  Fly   745 EYVNRTECFVEQYSRYHLADIDEYIDGELTLGENIADNGGMREAFYAYR------LYVKEVGRER 803

  Fly   628 TKETLPNL-RYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFN 691
            :|  ||.| .|:.:|||||||...||....|:.....: ||.|.||:.|:.|.|||.|||::.|.
  Fly   804 SK--LPGLEHYSHEQLFFISFGNLWCETYTPAASRYAL-TDSHCPGQMRLRGVLSNSEEFARTFK 865

  Fly   692 CPAGSAMNPSE-KCILY 707
            |..|:.|||.: ||.::
  Fly   866 CARGTPMNPDQPKCRIW 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	206/782 (26%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	202/773 (26%)
Nep5	NP_733186.2	PepO	146..882	CDD:226118	206/780 (26%)
Nep5	NP_733186.2	M13	151..880	CDD:189000	203/773 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.020