DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and MME

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_000893.2	Gene:	MME / 4311	HGNCID:	7154	Length:	750	Species:	Homo sapiens

Alignment Length:	742	Identity:	196/742 - (26%)
Similarity:	335/742 - (45%)	Gaps:	101/742 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 MVAAAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYKRINSALSMQVV 89
            |:|...|.::.:.:.:..:|...|..:.      ||...:||.||:.::||.:.:.| .:.....
Human    45 MIALYATYDDGICKSSDCIKSAARLIQN------MDATTEPCTDFFKYACGGWLKRN-VIPETSS 102

  Fly    90 TTGVFETLTKGLNRKILKMLNTPHDSHDTPEDI----KVKHFYESCLQIKELNSTYSEKLKRLIA 150
            ..|.|:.|...|...:..:|..|     ..|||    |.|..|.||:....::|...|.|.:|:.
Human   103 RYGNFDILRDELEVVLKDVLQEP-----KTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLP 162

  Fly   151 EFGTMPLLE-------GSSWQEDDFDWLNTTARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQ 208
            :....|:..       |:||..:     ...|::..:||...:..:.|..|..::..:.|::.|.
Human   163 DIYGWPVATENWEQKYGASWTAE-----KAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQP 222

  Fly   209 DFPLEARSMYVDDATAVYRQ------KYRNNIQRILQRYLGVKMD---LAKKTAKELIDFEVDLA 264
            ...|.:|..|  :.|.:|::      .:..::.|::::...:.:|   ||.:..| :::.|.::|
Human   223 RLGLPSRDYY--ECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNK-VMELEKEIA 284

  Fly   265 QGLVDESEGLDVGELTQLLTVDEIQRRYSPTLDIDRLLF------------VSMGERISDQIYEY 317
            .......:..|...|...:|:.:||..:|  |:|:...|            |::.....:.:..|
Human   285 NATAKPEDRNDPMLLYNKMTLAQIQNNFS--LEINGKPFSWLNFTNEIMSTVNISITNEEDVVVY 347

  Fly   318 NNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFV----ETPSDSPEKQMKACVDLTKK-------- 370
            ...|...|..::.:...|.:.|.:.:|.|.:.|    .|..:|.....||....|.:
Human   348 APEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCA 412

  Fly   371 -YFAKNLDNMFYRRYNNE----KSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQ 430
             |...|::|...|.|...    :|...::::..|::..|.:||..   |.|::..|:..|..|..
Human   413 NYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDD---LTWMDAETKKRAEEKAL 474

  Fly   431 AMTLEVNNYADD------NFTEEFAELNLQSDDYVENV----RYTSLLGAKQMREMLHKPAKPFE 485
            |:...: .|.||      ....|:.|||.:.|:|.||:    :::.....|::||.:.|......
Human   475 AIKERI-GYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISG 538

  Fly   486 AGSQLSYTPANILIENTIKVPVALLQPFYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDE 550
            |....::..:.   .|.|..|..:|||.: :|....|::.:|.:..:||||:.|||||:||.|::
Human   539 AAVVNAFYSSG---RNQIVFPAGILQPPF-FSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNK 599

  Fly   551 KGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYD---GIQLKESTAQSENIADNGGMRLAYTAYRK 612
            .|:..|||.::|:|||.::..|...|||.:.:|   |..|.......||||||||:..||.||:.
Human   600 DGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQN 664

  Fly   613 WYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVI 677
            :.:.     ||.:.:    ||.|....|||||::|||.||....|......:.||.|.||.||:|
Human   665 YIKK-----NGEEKL----LPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRII 720

  Fly   678 GSLSNFEEFSKEFNCPAGSAMNPSEKC 704
            |:|.|..|||:.|:|...|.|||.:||
Human   721 GTLQNSAEFSEAFHCRKNSYMNPEKKC 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	191/710 (27%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	187/702 (27%)
MME	NP_000893.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Stop-transfer sequence. /evidence=ECO:0000255	16..23
		M13	79..748	CDD:189000	189/702 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950