DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl21 and Ece2

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_006248635.1	Gene:	Ece2 / 408243	RGDID:	1303039	Length:	912	Species:	Rattus norvegicus

Alignment Length:	748	Identity:	212/748 - (28%)
Similarity:	343/748 - (45%)	Gaps:	107/748 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LCICIAGHVLSAMVAAAPTSEEDLKQDTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNY 77
            |.:.:|..:|..:||.......|....|...:..:|.|  .:|...:|:...||.|||.||||.:
  Rat   213 LILVLAALLLGCLVALWVQYHRDPVHSTCITEACIRVA--GKILESLDRGVSPCQDFYQFSCGGW 275

  Fly    78 KRINSALSMQVVTTGVFETLTKGLNRKILKML--NTPHDSHDTPEDIKVKHFYESCLQIKELNST 140
            .|.|...|.: .....|.:|. ..|:.|||.|  |:..:|....|. |.:.||.|||.::.:...
  Rat   276 IRRNPLPSGR-SRWNTFNSLW-DQNQAILKHLLENSTFNSSSEAER-KTRSFYLSCLHLERIEKL 337

  Fly   141 YSEKLKRLIAEFG----TMPLLEGSSWQEDDFDWLNTTARMAYRYGITPIFGIEVNKDLASNTRN 201
            .::.|:.||.:.|    |.|      |.||:|  :.....:|..|...|.|.:.|..|..|:..|
  Rat   338 GAKPLQDLIDKIGGWNITGP------WDEDNF--MEVLKAVAGTYRAAPFFTVYVGADSKSSNSN 394

  Fly   202 RIYLGQQDFPLEARSMYVDDATAVYRQKYRNNIQRILQRYLGVKMDL----------AKKTAKEL 256
            .|.:.|....|.:|..|::          |...:::|..||...::|          .:...:::
  Rat   395 IIQVDQSGLFLPSRDYYLN----------RTANEKVLAAYLDYMVELGMLLGGQPTSTRAQMQQV 449

  Fly   257 IDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLD-IDRLLF----VSMGERISDQIYE 316
            ::.|:.||...|.:.:..|..::...:::.|:| ..:|::| ::.|.|    :.:|:  |:.:..
  Rat   450 LELEIQLATITVPQDQRRDEEKIYHKMSISELQ-TLAPSMDWLEFLSFLLSPLELGD--SEPVVV 511

  Fly   317 YNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVETPSDSPEKQM-------------------- 361
            |...|.|.:.|:|.||....:.||    |||..|:..:.|.:::.
  Rat   512 YGTEYLQQVSELINRTEPSILNNY----LIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTP 572

  Fly   362 --KACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNL 424
              :.|:..|.......|.::|.:...:.:|....:.|..::::.|.|||.:   |.|::..||..
  Rat   573 RWQTCISNTDDALGFALGSLFVKATFDRQSKEIAEGMISEIRAAFEETLEN---LVWMDEKTRLA 634

  Fly   425 AMAKLQAMTLEVNNYADDNFTEEFAELN-------LQSDDYVENVRYTSLLGAKQMREMLHKPAK 482
            |..|..|: .::..:.|  |..|..||:       :..|.:.:|:.......||.|.:.|.||
  Rat   635 AKEKADAI-YDMIGFPD--FILEPRELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLRKP-- 694

  Fly   483 PFEAGSQLSYTPANI-----LIENTIKVPVALLQ-PFYIWSDVYPNAIMFGTLASLIGHELIHGF 541
              .:..|.|.||..:     ..:|.|..|..:|| |||..:  :|.|:.||.:..::||||.|.|
  Rat   695 --PSRDQWSMTPQTVNAYYLPTKNEIVFPAGILQAPFYAHN--HPKALNFGGIGVVMGHELTHAF 755

  Fly   542 DDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVYDGIQLKESTAQSENIADNGGMRLA 606
            ||.||::|::||.:.||..:|.:.|.....|..:||.:|..:|.:|.......||||||||::.|
  Rat   756 DDQGREYDQEGNLRPWWQNESLTAFQNHTACMEEQYNQYQVNGERLNGLQTLGENIADNGGLKAA 820

  Fly   607 YTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMP 671
            |.||:.|...     :|.:    :.||.:..|..||||:.|||.||:...|......:.||.|.|
  Rat   821 YNAYKAWLRK-----HGEE----QPLPAVGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTDPHSP 876

  Fly   672 GRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKC 704
            .||||:|:|||..:|.:.|.||.||.|||.:.|
  Rat   877 ARFRVLGTLSNSRDFLRHFGCPVGSPMNPGQLC 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	202/704 (29%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	200/696 (29%)
Ece2	XP_006248635.1	AdoMet_MTases	63..>128	CDD:302624
		PepO	250..903	CDD:226118	200/703 (28%)
		M13	261..910	CDD:189000	201/698 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344498
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950