DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and Nep2

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	734	Identity:	202/734 - (27%)
Similarity:	336/734 - (45%)	Gaps:	112/734 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 DTPYMKELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKGLNR 103
            |....:|.:..|.|  :...|..:.:||::||.|:||.|.. ...:....|:...|..::..|..
  Fly    82 DVCLTQECIHTAST--VLRKMKPEVEPCDNFYEFACGTYLE-EENIPDDKVSISTFSVISDKLQE 143

  Fly   104 KILKMLNTPHDSHDTPEDIKVKHF------YESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSS 162
            ::..::..     :.|| .:.|||      |::|:....:.:...|.:.|:....|..||::|.|
  Fly   144 QLKDIITA-----ERPE-TEPKHFRLPNLLYKACMNKTLIETLGPEPITRVAERLGGWPLIKGDS 202

  Fly   163 WQEDD-FDWLN-----TTARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDD 221
            |..|| :.|..     .||..:..|    |....:..||.::|:..|.|.|....| :|...|..
  Fly   203 WNADDSWTWQEQVKKFRTAGFSMDY----IIDFSIGVDLQNSTKRLIDLDQSSLAL-SREYLVKG 262

  Fly   222 -----ATAVYRQKYRNNIQRILQRYLGVKMDLAKKTAKELIDFEVDLAQGLVDESEGLDVGELTQ 281
                 .||.|  ||..:|..:    .|...||||......::||:.||.......:..:..||..
  Fly   263 FNETLVTAYY--KYMVDIAVL----FGANRDLAKTELLLSLEFEMALANISWPNEKRRNSSELYN 321

  Fly   282 LLTVDEIQRRYSPTLDIDRL-------LFVSMGERISDQIYEYNNRYQQNLVEVIKRTPKRTVAN 339
            |.|..::|..|.....:|.:       |.|:..|.|:..:    ..:.::|.:::.:||||.:||
  Fly   322 LRTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSV----PSFFEDLGKLLAKTPKRVIAN 382

  Fly   340 YIFFR--------LIWEFVE---------TPSDSPEKQMKACVDLTKKYFAK-----------NL 376
            |:|:|        |..||.:         :.....|.:.|.|||:......:           ::
  Fly   383 YMFWRIHGFSVGFLSEEFRKRQLQYATALSGRQEQEARWKECVDIATSSMDEVCEDDFDSLGISV 447

  Fly   377 DNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYAD 441
            .:::..::.::.|......|..::::.||:.|   ..:||::..|:..|..||.:|...: .|.|
  Fly   448 GSLYVGKHFHKDSKANALEMVNEIRNVFNDIL---DEVNWMDAKTKKEAKLKLHSMATHI-GYPD 508

  Fly   442 DNFTEE-----FAELNLQSDDYVENVRYTSLLGAKQMREMLHKP---------AKPFEAGSQLSY 492
            :....|     :|:|::..|.|.|:....::.|.......|..|         |:|....:..|
  Fly   509 EMLDNEKLAAYYAKLDIDPDKYFESFLGMNIFGTDYSFNKLRLPVNKTDWVRHARPAIVNAFYS- 572

  Fly   493 TPANILIENTIKVPVALLQPFYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDW 557
                 .:||:|:.|..:||. :.::...|..:.||.:..:||||:.|||||.||:||.|||.:||
  Fly   573 -----SLENSIQFPAGILQG-HFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQFDVKGNLRDW 631

  Fly   558 WDEKSSSNFLKRRDCFTKQYGRYV--YDGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTL 620
            |...:...:|.:..|..:|||.|.  ..|:.|.....|.||||||||::.:|.|||:|.|.
  Fly   632 WHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNGGVKESYIAYRRWAEK---- 692

  Fly   621 PNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEE 685
             :|.:    ..||.|.||.:|:|:::..|:||.........::::|..|.|..|||:|||||.::
  Fly   693 -HGPE----AKLPGLDYTPEQMFWVAAGQTWCAKYRKESLKMRITTGVHSPSEFRVLGSLSNMKD 752

  Fly   686 FSKEFNCPAGSAMNPSEKC 704
            |:|:|:||.||.|||.:||
  Fly   753 FAKDFHCPEGSPMNPVQKC 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	198/716 (28%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	195/708 (28%)
Nep2	NP_001246914.1	M13	104..772	CDD:189000	197/710 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3745
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.970