Protein Alignment Nepl21 and KEL

DIOPT Version :10

• Sequence 1: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: XP_005250050.1
• Gene: KEL / 3792
• HGNCID: 6308
• Length: 744
• Species: Homo sapiens
• Alignment Length: 710
• Identity: 160/710 - (22%)
• Similarity: 282/710 - (39%)
• Gaps: 143/710 - (20%)

  Fly    65 PCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKGLN--RKILKMLNTPHDSHDTPEDIKVKHF 127
            ||.||::|:||..|..|::..         |..||..|  |:||::.|:.|....   :.|...|
Human   111 PCTDFFSFACGRAKETNNSFQ---------ELATKNKNRLRRILEVQNSWHPGSG---EEKAFQF 163

  Fly   128 YESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAY-RYGITPIFGIEV 191
            |.||:....:.:..:..|:::|.|.|...:  ...|...:|   |.|.|:.. :||..|.|...:
Human   164 YNSCMDTLAIEAAGTGPLRQVIEELGGWRI--SGKWTSLNF---NRTLRLLMSQYGHFPFFRAYL 223

  Fly   192 NKDLASNTRNRIYLGQQDFPLEARSMYVDDATAVYRQKYR------NNIQRIL-------QRYLG 243
            ....||.....|.:.|.:|.:..:.   |....:|.|.:|      |.:..:|       |.:..
Human   224 GPHPASPHTPVIQIDQPEFDVPLKQ---DQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSS 285

  Fly   244 VKMDLAKKTAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLDIDRLL---FVS 305
            :.:.:..:..:.|...|...||           |:|.|::|:|:: :..:|.:|....|   |..
Human   286 LSISITSRLFQFLRPLEQRRAQ-----------GKLFQMVTIDQL-KEMAPAIDWLSCLQATFTP 338

  Fly   306 MGERISDQIYEYNNRYQQN---LVEVIKRTPKRTVANYIFFRLI--------------------- 346
            |....|..:..::..|.:|   |||.:....:..:.:::...|:
Human   339 MSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQK 403

  Fly   347 -WEFVETPSDSPEKQMKACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRS 410
             .|..|.|......:...||:.|..:|...|..:|.|......:......::..::......||:
Human   404 LRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRN 468

  Fly   411 SPALNWIERPTRNLAMAKLQAMTLEV--NNYA--DDNFTEEFAELNLQSDDYVENVRYTSLLGAK 471
            .|   |:...|:|:|..|:..:.:|:  :.:|  .:...:|:.::.|.|......:.....|.|:
Human   469 LP---WMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRAR 530

  Fly   472 QMREML-----HK-PAKPFEAGSQLSYTPANILIENTIKVPVALLQPFYIWSDVYPNAIMFGTLA 530
            .::..|     |: ...|::..:..|.:      ::.:..|..||||.: :...||.|:.||...
Human   531 IVQSFLQPHPQHRWKVSPWDVNAYYSVS------DHVVVFPAGLLQPPF-FHPGYPRAVNFGAAG 588

  Fly   531 SLIGHELIHGF------------DDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRY-VY 582
            |::.|||:|.|            |:...:                    :...|..:.|..: :.
Human   589 SIMAHELLHIFYQLLLPGGCLACDNHALQ--------------------EAHLCLKRHYAAFPLP 633

  Fly   583 DGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISF 647
            ......:|....||.||.||:.:|..||.|    :|...:|     :..||:|..:.:|:||.|:
Human   634 SRTSFNDSLTFLENAADVGGLAIALQAYSK----RLLRHHG-----ETVLPSLDLSPQQIFFRSY 689

  Fly   648 AQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKCILY 707
            ||..|....|     |.|.|.|.|...||.|.||:...|::.|.|..|:.:|||.:|.|:
Human   690 AQVMCRKPSP-----QDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	M13	63..704	CDD:341056	158/705 (22%)
KEL	XP_005250050.1	M13	109..742	CDD:341056	158/706 (22%)