DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and KEL

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_005250050.1	Gene:	KEL / 3792	HGNCID:	6308	Length:	744	Species:	Homo sapiens

Alignment Length:	710	Identity:	160/710 - (22%)
Similarity:	282/710 - (39%)	Gaps:	143/710 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 PCNDFYAFSCGNYKRINSALSMQVVTTGVFETLTKGLN--RKILKMLNTPHDSHDTPEDIKVKHF 127
            ||.||::|:||..|..|::..         |..||..|  |:||::.|:.|....   :.|...|
Human   111 PCTDFFSFACGRAKETNNSFQ---------ELATKNKNRLRRILEVQNSWHPGSG---EEKAFQF 163

  Fly   128 YESCLQIKELNSTYSEKLKRLIAEFGTMPLLEGSSWQEDDFDWLNTTARMAY-RYGITPIFGIEV 191
            |.||:....:.:..:..|:::|.|.|...:  ...|...:|   |.|.|:.. :||..|.|...:
Human   164 YNSCMDTLAIEAAGTGPLRQVIEELGGWRI--SGKWTSLNF---NRTLRLLMSQYGHFPFFRAYL 223

  Fly   192 NKDLASNTRNRIYLGQQDFPLEARSMYVDDATAVYRQKYR------NNIQRIL-------QRYLG 243
            ....||.....|.:.|.:|.:..:.   |....:|.|.:|      |.:..:|       |.:..
Human   224 GPHPASPHTPVIQIDQPEFDVPLKQ---DQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSS 285

  Fly   244 VKMDLAKKTAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQRRYSPTLDIDRLL---FVS 305
            :.:.:..:..:.|...|...||           |:|.|::|:|:: :..:|.:|....|   |..
Human   286 LSISITSRLFQFLRPLEQRRAQ-----------GKLFQMVTIDQL-KEMAPAIDWLSCLQATFTP 338

  Fly   306 MGERISDQIYEYNNRYQQN---LVEVIKRTPKRTVANYIFFRLI--------------------- 346
            |....|..:..::..|.:|   |||.:....:..:.:::...|:
Human   339 MSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQK 403

  Fly   347 -WEFVETPSDSPEKQMKACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRS 410
             .|..|.|......:...||:.|..:|...|..:|.|......:......::..::......||:
Human   404 LRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRN 468

  Fly   411 SPALNWIERPTRNLAMAKLQAMTLEV--NNYA--DDNFTEEFAELNLQSDDYVENVRYTSLLGAK 471
            .|   |:...|:|:|..|:..:.:|:  :.:|  .:...:|:.::.|.|......:.....|.|:
Human   469 LP---WMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRAR 530

  Fly   472 QMREML-----HK-PAKPFEAGSQLSYTPANILIENTIKVPVALLQPFYIWSDVYPNAIMFGTLA 530
            .::..|     |: ...|::..:..|.:      ::.:..|..||||.: :...||.|:.||...
Human   531 IVQSFLQPHPQHRWKVSPWDVNAYYSVS------DHVVVFPAGLLQPPF-FHPGYPRAVNFGAAG 588

  Fly   531 SLIGHELIHGF------------DDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRY-VY 582
            |::.|||:|.|            |:...:                    :...|..:.|..: :.
Human   589 SIMAHELLHIFYQLLLPGGCLACDNHALQ--------------------EAHLCLKRHYAAFPLP 633

  Fly   583 DGIQLKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFISF 647
            ......:|....||.||.||:.:|..||.|    :|...:|     :..||:|..:.:|:||.|:
Human   634 SRTSFNDSLTFLENAADVGGLAIALQAYSK----RLLRHHG-----ETVLPSLDLSPQQIFFRSY 689

  Fly   648 AQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKCILY 707
            ||..|....|     |.|.|.|.|...||.|.||:...|::.|.|..|:.:|||.:|.|:
Human   690 AQVMCRKPSP-----QDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	159/708 (22%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	158/705 (22%)
KEL	XP_005250050.1	PepO	106..744	CDD:226118	159/708 (22%)
KEL	XP_005250050.1	M13	109..742	CDD:189000	158/706 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151004
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.950