DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and Nep1

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001284925.1	Gene:	Nep1 / 31547	FlyBaseID:	FBgn0029843	Length:	849	Species:	Drosophila melanogaster

Alignment Length:	777	Identity:	203/777 - (26%)
Similarity:	350/777 - (45%)	Gaps:	103/777 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IKAKHNAKQLLCICIAGHVLSAMVAA-----------------APTSEEDLK------------- 37
            :|.....::||.:.||..||.|.:.|                 .|.:::...
  Fly   104 LKESQQRRRLLVLAIAFTVLGAAIGALAIYFASVHQRCHLYRLEPDNDDRPNGRWNQDSGSAHEG 168

  Fly    38 QDTPYM-KELLRQAKTAEIESFMDQKADPCNDFYAFSCGNYKRIN------SALSMQVVTTGVFE 95
            ||...| :|.:|.|  |.:.|.||..:|||.||:.::||.:.:::      |::|       .||
  Fly   169 QDNICMTQECVRTA--ASLLSAMDLNSDPCEDFFQYACGTWNKMHPIPEDRSSIS-------TFE 224

  Fly    96 TLTKGLNRKILKMLNTPHDSHDTPEDIKVKHFYESCLQIKELNSTYSEKLKRLIAEFGTMPLLEG 160
            .|:......:..:|..|.|..|....||.|.|::||:.|.::....:.:||:::...|..|::|.
  Fly   225 VLSDQQQVILRAVLEEPIDERDNKATIKAKTFFKSCMDIPQIRKIGTGRLKQVLQSLGGWPVIER 289

  Fly   161 SSWQEDDFDWLNTTARMAYRYGITPIFGIEVNKDLASNTRNRIYLGQQDFPLEARSMYVDDATAV 225
            :.....|........::...|....:..:.|..|..:::.|.:.:.|..:.|.:|..|:.:::|.
  Fly   290 NWSPPADLSVERLMGQLRLNYSEPVMIELYVGADDKNSSVNILQMDQLQYALPSRDYYLKESSAN 354

  Fly   226 YRQKYRNNIQRILQRYLGVKMDLAKKTAKELIDFEVDLAQGLVDESEGLDVGELTQLLTVDEIQR 290
            .|:.|...:.:: ...||.....|....::::.||..|....:.|::..|...:.:.:.:.|:|
  Fly   355 DRRAYHRYMTQV-ALLLGADPATAAAELEKVVLFETQLVNVSLPEADRHDTSLVYRKMLLPELQ- 417

  Fly   291 RYSPTLDIDRLLFVSMGERI----SDQIYEYNNRYQQNLVEVIKRTPKRTVANYIFFRLIWEFVE 351
            ...|.:.....|..::|..|    .:.:..|...|...:.:::..|.:|.|.||:.:||:...:.
  Fly   418 ELVPEVQWQEYLQAALGPGIPLQEDEPLVTYGLHYLTEMGKILAHTDRRVVHNYMLWRLVMSLMS 482

  Fly   352 TPSD-----------------SPEKQMKACVDLTKKYFAKNLDNMFYRRYNNEKSSREIDNMWRQ 399
            ...|                 |...:...||:.|.|.....:..:|.|...|::|......|...
  Fly   483 HMIDEYQRERVEFRKILMGIQSERTRWSQCVEWTNKKLGVAVGALFIRDNFNQESKEVALEMIHT 547

  Fly   400 LKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTLEVNNYAD--DNFTE---EFAELNLQSDDYV 459
            :::.|||.|..:   :|::..||.:|..|..:|...: .|.:  .|.||   |:..|.:..|:::
  Fly   548 IRAAFNELLAEN---DWMDDETRAVAKEKADSMNERI-GYPELLTNATELEQEYVNLTIVPDNFI 608

  Fly   460 ENVRYTSLLGAKQMREMLHKP-------AKPFEAGSQLSYTPANILIENTIKVPVALLQPFYIWS 517
            .||.......:::|..:|.:|       .:|  |.....|.|.    :|.|..|..:|||.: :|
  Fly   609 NNVLSILQWESEKMLRLLRQPVDKEKWTTEP--AVVNAFYNPN----KNDIVFPAGILQPLF-YS 666

  Fly   518 DVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGNSKDWWDEKSSSNFLKRRDCFTKQYGRYVY 582
            ..:|.::.:|.:..:||||:.|||||.||:||::||...||:..:...|.:|..|...||.||..
  Fly   667 QHFPKSLNYGGIGVVIGHEITHGFDDKGRQFDKEGNMMQWWNNATIEAFRERTQCVIDQYSRYKI 731

  Fly   583 DGIQ--LKESTAQSENIADNGGMRLAYTAYRKWYENQLTLPNGAQDMTKETLPNLRYTAKQLFFI 645
            :.:.  :.....|.||||||||::.|:.||:||.    ||....|.     ||.|..|..||||:
  Fly   732 NEVDMFMDGRMTQGENIADNGGLKQAFRAYKKWE----TLHGREQQ-----LPGLNMTHDQLFFL 787

  Fly   646 SFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSLSNFEEFSKEFNCPAGSAMNPSEKCILY 707
            ::||.||....|.....::.:..|.||..||:|.|||..:|:..:.||.||.|||:|||.::
  Fly   788 NYAQIWCGSMRPEDALTKIRSAVHSPGFVRVLGPLSNSRDFASAYKCPLGSTMNPAEKCSVW 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	186/690 (27%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	181/681 (27%)
Nep1	NP_001284925.1	M13	194..847	CDD:189000	182/681 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.950