Protein Alignment Nepl21 and Mmel1

DIOPT Version :10

• Sequence 1: NP_651646.2
• Gene: Nepl21 / 43413
• FlyBaseID: FBgn0027578
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_001101467.2
• Gene: Mmel1 / 313755
• RGDID: 1309299
• Length: 774
• Species: Rattus norvegicus
• Alignment Length: 742
• Identity: 200/742 - (26%)
• Similarity: 335/742 - (45%)
• Gaps: 103/742 - (13%)

  Fly    37 KQDTPYMKELLRQAK--------------TAEIESFMDQKADPCNDFYAFSCGNYKR------IN 81
            :.:...:|.:||.:.              .|.|...|||...||::||.::||.:.|      .|
  Rat    65 RHERTVVKRVLRDSSQKSDICTTPSCVIAAARILQNMDQSKKPCDNFYQYACGGWLRHHVIPETN 129

  Fly    82 SALSMQVVTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIKVKHFYESCLQIKELNSTYSEKLK 146
            |..|:..:.....|.:.||    :|:..:..|    .|...|.|..|.||:....:....||.|.
  Rat   130 SRYSVFDILRDELEVILKG----VLEDSSVQH----RPAVEKAKTLYRSCMNQSVIEKRDSEPLL 186

  Fly   147 RLIAEFGTMPL-------LEGSSWQ-EDDFDWLNTTARMAYRYGITPIFGIEVNKDLASNTRNRI 203
            .::...|..|:       ..|..|: |.....||:      ::....:..:.:..|..:::|:.|
  Rat   187 NVLDMIGGWPVAMDKWNETMGPKWELERQLAVLNS------QFNRRVLIDLFIWNDDQNSSRHVI 245

  Fly   204 YLGQQDFPLEARSMYVDDATAVYRQKY---RNNIQRILQRYLGV--KMDLAKKTAKELIDFEVDL 263
            |:.|....:.:|..|..:.:...|:.|   ..::..:|:|.|.:  :.||.::...:::..|..|
  Rat   246 YIDQPTLGMPSREYYFKEDSHRVREAYLQFMTSVATMLRRDLNLPGETDLVQEEMAQVLHLETHL 310

  Fly   264 AQGLVDESEGLDVGELTQLLTVDEIQRR-----YSPTLDIDRLLFVSMGERI-SDQIYEYNNRYQ 322
            |...|.:.:..||..|...:.::|:|.|     ::.||.|..:|.....|.: ::::..|...|.
  Rat   311 ANATVPQEKRHDVTALYHRMGLEELQERFGLKGFNWTLFIQNVLSSVQVELLPNEEVVVYGIPYL 375

  Fly   323 QNLVEVIKRTPKRTVANYIFFRLIWE--------FVETPSD---------SPEKQMKACVDLTKK 370
            :||.|:|...|.:|:.||:.:||:.:        |.|...|         ..|.:.:.||.....
  Rat   376 ENLEEIIDVFPAQTLQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTMEEVRWRECVSYVNS 440

  Fly   371 YFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTL- 434
            .....:.:::.:|..::.|...:..:..:::|.|.:.|   ..|||::..::..|..|  |:.:
  Rat   441 NMESAVGSLYIKRAFSKDSKSIVSELIEKIRSVFVDNL---DELNWMDEESKKKAQEK--ALNIR 500

  Fly   435 EVNNYAD----DN---FTEEFAELNLQSDDYVE----NVRYTSLLGAKQMREMLHKPAKPFEAGS 488
            |...|.|    ||   ..||::.|....|.|.|    |::..:....|::||.:.:......|..
  Rat   501 EQIGYPDYILEDNNRHLDEEYSSLTFSEDLYFENGLQNLKNNAQRSLKKLREKVDQNLWIIGAAV 565

  Fly   489 QLSYTPANILIENTIKVPVALLQPFYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGN 553
            ..::...|   .|.|..|..:|||.:...| .|.|:.||.:..:||||:.|||||:||.||:.||
  Rat   566 VNAFYSPN---RNLIVFPAGILQPPFFSKD-QPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGN 626

  Fly   554 SKDWWDEKSSSNFLKRRDCFTKQYGRYVY---DGIQLKESTAQSENIADNGGMRLAYTAYRKWYE 615
            ..|||...|:.:|.::..|...||..:.:   |...:...:...||||||||:|.||.||.:|
  Rat   627 MLDWWSNFSARHFRQQSQCMIYQYSNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLQW-- 689

  Fly   616 NQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSL 680
                |..|.:|   :.||.|..|..|||||::||.||....|......:.||.|.|.::||:|||
  Rat   690 ----LAEGGRD---QRLPGLNLTYAQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSL 747

  Fly   681 SNFEEFSKEFNCPAGSAMNPSEKCILY 707
            .|...||:.|:||.||.|:|..:|.::
  Rat   748 QNLPGFSEAFHCPRGSPMHPMNRCRIW 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	M13	63..704	CDD:341056	191/697 (27%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
		M13	106..772	CDD:341056	191/697 (27%)