DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl21 and Mmel1

DIOPT Version :9

Sequence 1:	NP_651646.2	Gene:	Nepl21 / 43413	FlyBaseID:	FBgn0027578	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001101467.2	Gene:	Mmel1 / 313755	RGDID:	1309299	Length:	774	Species:	Rattus norvegicus

Alignment Length:	742	Identity:	200/742 - (26%)
Similarity:	335/742 - (45%)	Gaps:	103/742 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 KQDTPYMKELLRQAK--------------TAEIESFMDQKADPCNDFYAFSCGNYKR------IN 81
            :.:...:|.:||.:.              .|.|...|||...||::||.::||.:.|      .|
  Rat    65 RHERTVVKRVLRDSSQKSDICTTPSCVIAAARILQNMDQSKKPCDNFYQYACGGWLRHHVIPETN 129

  Fly    82 SALSMQVVTTGVFETLTKGLNRKILKMLNTPHDSHDTPEDIKVKHFYESCLQIKELNSTYSEKLK 146
            |..|:..:.....|.:.||    :|:..:..|    .|...|.|..|.||:....:....||.|.
  Rat   130 SRYSVFDILRDELEVILKG----VLEDSSVQH----RPAVEKAKTLYRSCMNQSVIEKRDSEPLL 186

  Fly   147 RLIAEFGTMPL-------LEGSSWQ-EDDFDWLNTTARMAYRYGITPIFGIEVNKDLASNTRNRI 203
            .::...|..|:       ..|..|: |.....||:      ::....:..:.:..|..:::|:.|
  Rat   187 NVLDMIGGWPVAMDKWNETMGPKWELERQLAVLNS------QFNRRVLIDLFIWNDDQNSSRHVI 245

  Fly   204 YLGQQDFPLEARSMYVDDATAVYRQKY---RNNIQRILQRYLGV--KMDLAKKTAKELIDFEVDL 263
            |:.|....:.:|..|..:.:...|:.|   ..::..:|:|.|.:  :.||.::...:::..|..|
  Rat   246 YIDQPTLGMPSREYYFKEDSHRVREAYLQFMTSVATMLRRDLNLPGETDLVQEEMAQVLHLETHL 310

  Fly   264 AQGLVDESEGLDVGELTQLLTVDEIQRR-----YSPTLDIDRLLFVSMGERI-SDQIYEYNNRYQ 322
            |...|.:.:..||..|...:.::|:|.|     ::.||.|..:|.....|.: ::::..|...|.
  Rat   311 ANATVPQEKRHDVTALYHRMGLEELQERFGLKGFNWTLFIQNVLSSVQVELLPNEEVVVYGIPYL 375

  Fly   323 QNLVEVIKRTPKRTVANYIFFRLIWE--------FVETPSD---------SPEKQMKACVDLTKK 370
            :||.|:|...|.:|:.||:.:||:.:        |.|...|         ..|.:.:.||.....
  Rat   376 ENLEEIIDVFPAQTLQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTMEEVRWRECVSYVNS 440

  Fly   371 YFAKNLDNMFYRRYNNEKSSREIDNMWRQLKSTFNETLRSSPALNWIERPTRNLAMAKLQAMTL- 434
            .....:.:::.:|..::.|...:..:..:::|.|.:.|   ..|||::..::..|..|  |:.:
  Rat   441 NMESAVGSLYIKRAFSKDSKSIVSELIEKIRSVFVDNL---DELNWMDEESKKKAQEK--ALNIR 500

  Fly   435 EVNNYAD----DN---FTEEFAELNLQSDDYVE----NVRYTSLLGAKQMREMLHKPAKPFEAGS 488
            |...|.|    ||   ..||::.|....|.|.|    |::..:....|::||.:.:......|..
  Rat   501 EQIGYPDYILEDNNRHLDEEYSSLTFSEDLYFENGLQNLKNNAQRSLKKLREKVDQNLWIIGAAV 565

  Fly   489 QLSYTPANILIENTIKVPVALLQPFYIWSDVYPNAIMFGTLASLIGHELIHGFDDSGRKFDEKGN 553
            ..::...|   .|.|..|..:|||.:...| .|.|:.||.:..:||||:.|||||:||.||:.||
  Rat   566 VNAFYSPN---RNLIVFPAGILQPPFFSKD-QPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGN 626

  Fly   554 SKDWWDEKSSSNFLKRRDCFTKQYGRYVY---DGIQLKESTAQSENIADNGGMRLAYTAYRKWYE 615
            ..|||...|:.:|.::..|...||..:.:   |...:...:...||||||||:|.||.||.:|
  Rat   627 MLDWWSNFSARHFRQQSQCMIYQYSNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLQW-- 689

  Fly   616 NQLTLPNGAQDMTKETLPNLRYTAKQLFFISFAQSWCNDAHPSVKALQVSTDQHMPGRFRVIGSL 680
                |..|.:|   :.||.|..|..|||||::||.||....|......:.||.|.|.::||:|||
  Rat   690 ----LAEGGRD---QRLPGLNLTYAQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSL 747

  Fly   681 SNFEEFSKEFNCPAGSAMNPSEKCILY 707
            .|...||:.|:||.||.|:|..:|.::
  Rat   748 QNLPGFSEAFHCPRGSPMHPMNRCRIW 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl21	NP_651646.2	PepO	57..707	CDD:226118	195/706 (28%)
Nepl21	NP_651646.2	M13	63..704	CDD:189000	191/697 (27%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
Mmel1	NP_001101467.2	M13	106..772	CDD:341056	191/697 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344520
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950